KR870000958B1 - 불포화된 고리형 아미도-치환된 에테르 화합물의 제조방법 - Google Patents

불포화된 고리형 아미도-치환된 에테르 화합물의 제조방법 Download PDF

Info

Publication number
KR870000958B1
KR870000958B1 KR1019850001614A KR850001614A KR870000958B1 KR 870000958 B1 KR870000958 B1 KR 870000958B1 KR 1019850001614 A KR1019850001614 A KR 1019850001614A KR 850001614 A KR850001614 A KR 850001614A KR 870000958 B1 KR870000958 B1 KR 870000958B1
Authority
KR
South Korea
Prior art keywords
acrylamidobutoxy
butyl
acrylamide
bis
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019850001614A
Other languages
English (en)
Korean (ko)
Other versions
KR850006924A (ko
Inventor
히로시 이또
아쓰히꼬 니따
도미오 다나까
히데오 가미오
Original Assignee
미쓰이도오아쓰 가가꾸 가부시끼가이샤
오꾸 미쓰오
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 미쓰이도오아쓰 가가꾸 가부시끼가이샤, 오꾸 미쓰오 filed Critical 미쓰이도오아쓰 가가꾸 가부시끼가이샤
Publication of KR850006924A publication Critical patent/KR850006924A/ko
Application granted granted Critical
Publication of KR870000958B1 publication Critical patent/KR870000958B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1019850001614A 1984-03-13 1985-03-13 불포화된 고리형 아미도-치환된 에테르 화합물의 제조방법 Expired KR870000958B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59046532A JPS60193955A (ja) 1984-03-13 1984-03-13 環式不飽和アミド置換エ−テル化合物及びその製造方法
JP46532/84 1984-03-13

Publications (2)

Publication Number Publication Date
KR850006924A KR850006924A (ko) 1985-10-25
KR870000958B1 true KR870000958B1 (ko) 1987-05-14

Family

ID=12749894

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850001614A Expired KR870000958B1 (ko) 1984-03-13 1985-03-13 불포화된 고리형 아미도-치환된 에테르 화합물의 제조방법

Country Status (6)

Country Link
US (1) US4649219A (https=)
EP (1) EP0155177B1 (https=)
JP (1) JPS60193955A (https=)
KR (1) KR870000958B1 (https=)
CA (1) CA1244012A (https=)
DE (1) DE3580293D1 (https=)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100490339B1 (ko) * 2002-05-08 2005-05-17 국방과학연구소 2,2-디나이트로프로필 아크릴레이트와 2,2-디나이트로부틸아크릴레이트의 공중합체
US9745319B2 (en) 2013-03-15 2017-08-29 Araxes Pharma Llc Irreversible covalent inhibitors of the GTPase K-Ras G12C
UY35464A (es) 2013-03-15 2014-10-31 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
US10011600B2 (en) 2014-09-25 2018-07-03 Araxes Pharma Llc Methods and compositions for inhibition of Ras
ES2826443T3 (es) 2014-09-25 2021-05-18 Araxes Pharma Llc Inhibidores de proteínas mutantes KRAS G12C
JP2018513853A (ja) 2015-04-10 2018-05-31 アラクセス ファーマ エルエルシー 置換キナゾリン化合物およびその使用方法
JP6789239B2 (ja) 2015-04-15 2020-11-25 アラクセス ファーマ エルエルシー Ｋｒａｓの縮合三環系インヒビターおよびその使用の方法
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
EP3133065A1 (en) 2015-08-21 2017-02-22 Merck Patent GmbH Compounds for optically active devices
WO2017058915A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
EP3356353A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
EP3356354A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
WO2017058807A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2017058902A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10882847B2 (en) 2015-09-28 2021-01-05 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10647703B2 (en) 2015-09-28 2020-05-12 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
JP2018533939A (ja) 2015-10-19 2018-11-22 アラクセス ファーマ エルエルシー Ｒａｓの阻害剤をスクリーニングするための方法
KR20180081596A (ko) 2015-11-16 2018-07-16 아락세스 파마 엘엘씨 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법
WO2017100546A1 (en) 2015-12-09 2017-06-15 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
CN106986789B (zh) * 2016-01-20 2019-07-16 中国人民解放军军事医学科学院生物医学分析中心 对苯二酚类化合物及其制备方法与在抗肿瘤或免疫调节中的应用
WO2017172979A1 (en) 2016-03-30 2017-10-05 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
US10280172B2 (en) 2016-09-29 2019-05-07 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
EP3523289A1 (en) 2016-10-07 2019-08-14 Araxes Pharma LLC Heterocyclic compounds as inhibitors of ras and methods of use thereof
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
WO2018140599A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
WO2018140513A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
CN110382482A (zh) 2017-01-26 2019-10-25 亚瑞克西斯制药公司 稠合的杂-杂二环化合物及其使用方法
EP3573954A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
EP3363793A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Hydrophobic compounds for optically active devices
EP3363786A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Compounds for optically active devices
JP2020521741A (ja) 2017-05-25 2020-07-27 アラクセス ファーマ エルエルシー がんの処置のための化合物およびその使用の方法
US11639346B2 (en) 2017-05-25 2023-05-02 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS
AU2018271990A1 (en) 2017-05-25 2019-12-12 Araxes Pharma Llc Covalent inhibitors of KRAS
MX2021000887A (es) 2018-08-01 2021-03-31 Araxes Pharma Llc Compuestos espiroheterociclicos y metodos de uso de los mismos para el tratamiento de cancer.
EP4015512A1 (en) * 2020-12-16 2022-06-22 AMO Ireland Optically active devices

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2773063A (en) * 1956-12-04 Preparation of acrylamides
DE8498C (de) * Graf CH. DE MONTBLANC und L. GAULARD, Chemiker, in Paris Apparate zur Bereitung der sogenannten Ammoniak-Soda
DE312689C (https=) *
DE312687C (https=) *
US2773899A (en) * 1953-11-24 1956-12-11 Cilag Ltd Alkenoic amides of arylethers of alkanolamines
US3037056A (en) * 1959-03-30 1962-05-29 California Research Corp Amido polyglycols
US3280189A (en) * 1961-11-17 1966-10-18 Devoe & Raynolds Co Preparation of alcohol blocked n-hydroxymethyl unsaturated acid amides
NL288928A (https=) * 1962-02-14
NL293393A (https=) * 1962-06-04
NL302380A (https=) * 1962-12-22 1900-01-01
GB1010760A (en) * 1963-09-18 1965-11-24 Hercules Powder Co Ltd Modified polyolefines
DE1443912C3 (de) * 1964-12-08 1975-07-10 Bayer Ag, 5090 Leverkusen 3,5-Dialkyl-4-hydroxy-benzylamide der Acryl- bzw. Methacrylsäure und Verfahren zu ihrer Herstellung
US3627831A (en) * 1965-04-01 1971-12-14 Ciba Ltd Carboxylic acid amides
US3652478A (en) * 1967-10-27 1972-03-28 Mitsubishi Rayon Co Coating composition for electrodeposition coating
CH500168A (de) * 1968-04-19 1970-12-15 Basf Ag Verfahren zur Herstellung von Alkylenglykol-di(-acrylamid-N-methyl)-äthern
BE759428A (fr) * 1969-11-28 1971-04-30 Eastman Kodak Co Nouveaux composes acryliques monomeres et polymeres, utilisables en optique, et procede de preparation
US3796773A (en) * 1971-03-19 1974-03-12 Lubrizol Corp Graft polymers
US3784565A (en) * 1971-10-29 1974-01-08 Goodrich Co B F Stabilizers for chlorine-containing polymers
GB1415159A (en) * 1971-11-25 1975-11-26 Coates Bros Co Ltd Copolymers
US4233430A (en) * 1973-06-26 1980-11-11 L'oreal Anti-solar acrylamide derivative polymers, method of making the same and cosmetic compositions containing the same
US4025548A (en) * 1974-02-04 1977-05-24 The O'brien Corporation Radiation curable oligomers
US3928499A (en) * 1974-02-19 1975-12-23 Dow Chemical Co Unsaturated poly(amide-esters) and cross-linked derivatives thereof
CA1019485A (en) * 1974-06-21 1977-10-18 Sed Systems Ltd. Automatic dialing equipment
US4172933A (en) * 1975-07-16 1979-10-30 Xerox Corporation Polymers having pendant acceptor groups
US4021404A (en) * 1975-10-01 1977-05-03 The Goodyear Tire & Rubber Company Antihardeners for polymers
US4129545A (en) * 1976-01-16 1978-12-12 Mitsubishi Rayon Co., Ltd. Thermosetting acrylic copolymer usable as a powder paint and method for producing the same
US4134916A (en) * 1978-02-06 1979-01-16 Texaco Development Corp. N-polyalkoxyalkyl acrylamides or methacrylamides
US4393237A (en) * 1981-07-02 1983-07-12 Texaco Inc. Polyoxyalkylenepolyacrylamides

Also Published As

Publication number Publication date
DE3580293D1 (de) 1990-12-06
US4649219A (en) 1987-03-10
CA1244012A (en) 1988-11-01
EP0155177B1 (en) 1990-10-31
JPH0573739B2 (https=) 1993-10-15
EP0155177A2 (en) 1985-09-18
EP0155177A3 (en) 1987-02-04
JPS60193955A (ja) 1985-10-02
KR850006924A (ko) 1985-10-25

Similar Documents

Publication Publication Date Title
KR870000958B1 (ko) 불포화된 고리형 아미도-치환된 에테르 화합물의 제조방법
CZ34595A3 (en) Intermediates for preparing aromatic aminoalcohol derivatives and process for preparing thereof
FR2670491A1 (fr) Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
JPS6130652B2 (https=)
SU719490A3 (ru) Способ получени ароилзамещенных фенилуксусных кислот
EP0297782B1 (en) A thiophene derivative and process for preparing the same
JPS63258861A (ja) ニトロエテン誘導体の製造法
EP0074725A1 (en) A method for the production of nuclear substituted cinnamoylanthranilic acid derivatives and intermediates thereof
US3261868A (en) Aminoalkoxy-hydroxyacetophenones
US2772276A (en) Basic esters of n-aryl-n-(heterocyclylalkyl) carbamic acids and syntheses thereof
CA1327200C (en) Urea derivatives
SU980616A3 (ru) Способ получени производных простых фениловых эфиров
JPH0150218B2 (https=)
BE898219A (fr) Nouveaux dérivés d'amine, leurs sels, procédé pour les préparer, et agent anti-ulcéreux les contenant.
KR100426534B1 (ko) 아젤라스틴의 개선된 합성방법
JPS6259707B2 (https=)
Price et al. The Synthesis of 4-Hydroxyquinolines. X. Quinoline Derivatives with Sulfur-Containing Substituents1
GB2134521A (en) Improvements in or relating to the synthesis of nizatidine
CN118530232A (zh) 一种(s)-2-(2-苯基缩水甘油醚)噻吩的制备方法及其产品和应用
SU122753A3 (ru) Способ получени производных фенотиазина
JP2569732B2 (ja) エステル誘導体およびその製造法
SU168668A1 (https=)
JPS5922708B2 (ja) インダゾ−ル誘導体の製法
JPH01249739A (ja) オルトー脂肪族オキシフェノール誘導体の製造方法
JPH0710786B2 (ja) 環式ハロゲン置換エーテル化合物およびその製造方法

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

FPAY Annual fee payment

Payment date: 19900331

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19910515

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19910515

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000