KR860008134A - 아제티딘 유도체 및 그 중간체의 제조방법 - Google Patents
아제티딘 유도체 및 그 중간체의 제조방법 Download PDFInfo
- Publication number
- KR860008134A KR860008134A KR1019860002829A KR860002829A KR860008134A KR 860008134 A KR860008134 A KR 860008134A KR 1019860002829 A KR1019860002829 A KR 1019860002829A KR 860002829 A KR860002829 A KR 860002829A KR 860008134 A KR860008134 A KR 860008134A
- Authority
- KR
- South Korea
- Prior art keywords
- nickel
- group
- hydrogen atom
- phenyl
- salt
- Prior art date
Links
- 150000001539 azetidines Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 13
- 238000000034 method Methods 0.000 claims 7
- 229910052759 nickel Inorganic materials 0.000 claims 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000003647 oxidation Effects 0.000 claims 3
- 238000007254 oxidation reaction Methods 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- -1 nickel peroxide Chemical class 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- GNVWVYIAQBJHGV-UHFFFAOYSA-N azetidin-3-ylmethanol Chemical class OCC1CNC1 GNVWVYIAQBJHGV-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003792 electrolyte Substances 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 239000013067 intermediate product Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 150000002978 peroxides Chemical group 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 산화 상태가 적어도 3인 니켈을 하기 구조식(Ⅱ)의 3-히드록시메틸 아제티딘 유도체와 접촉시키고, 이어서, R5가 수소 원자가 아닐 때 3,3-디카르복실 중간 생성물을 또는 그 염을 탈카르복실화하고, 필요하다면 N-원자를 탈보호하여 R1이 수소원자인 화합물을 생성하는 것으로 구성된 구조식(Ⅰ)의 화합물 또는 그 염의 제조방법.상기식에서, R1은 수소 원자 또는 구조식 R2SO2의 기 또는 페닐-CH(R3)-이고 여기서, R2는 페닐, 톨릴 또는 C1-4알킬기이고 R3는 수소원자 또는 페닐 또는 C1-4알킬기이다.상기식에서 R4는 구조식 R2SO2의 기 또는 페닐-CH(R3)-이고 여기서, R5수소원자 또는 히드록시메틸기 또는 구조식 COOH의 기 또는 그 염이다.
- 제1항에 있어서, R1이 토실 또는 벤질기인 방법.
- 제1항 또는 제2항에 있어서, 필수적 산화 상태 3의 니켈이 과산화 형태를 존재하는 방법.
- 제3항에 있어서, 과산화 니켈이 차아할로겐산 알칼리 금속 및니(Ⅱ)켈염의 반응에 의해 화학적으로 현장에서 생성되는 방법.
- 제1항 또는 제2항에 있어서, 필수적 산화상태 3의 니켈이 전기화학 셀의 니켈 표면 양극인 방법.
- 제5항에 있어서, 양극 니켈 표면이 니켈을 니켈(Ⅱ)이온 및 수산화 알칼리 금속과 접촉시키면서 전류를 통과시킴으로 활성화되는 방법.
- 제5항 또는 제6항에 있어서, 전기화학 셀이, 전해질이 통과해 흐를수 있는, 전극층과 전기 절연간 격층의 유연한 샌드위치를 나선형으로 하여 형성된 전극 롤로 구성된 방법.
- 제5항, 제6항 또는 제7항에 있어서, 통과되는 전하가 반응물(Ⅱ)몰당 8-11패러데이인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858509746A GB8509746D0 (en) | 1985-04-16 | 1985-04-16 | Preparing azetidine derivatives |
| GB8509746 | 1985-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR860008134A true KR860008134A (ko) | 1986-11-12 |
Family
ID=10577742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019860002829A KR860008134A (ko) | 1985-04-16 | 1986-04-14 | 아제티딘 유도체 및 그 중간체의 제조방법 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US4778577A (ko) |
| EP (1) | EP0199413A3 (ko) |
| JP (1) | JPS61238991A (ko) |
| KR (1) | KR860008134A (ko) |
| CN (1) | CN86102422A (ko) |
| AU (1) | AU584412B2 (ko) |
| BR (1) | BR8601677A (ko) |
| DD (1) | DD244552A5 (ko) |
| DK (1) | DK169386A (ko) |
| ES (1) | ES8707494A1 (ko) |
| GB (1) | GB8509746D0 (ko) |
| GR (1) | GR860978B (ko) |
| HU (1) | HU201303B (ko) |
| IL (1) | IL78491A (ko) |
| NO (1) | NO861447L (ko) |
| NZ (1) | NZ215815A (ko) |
| OA (1) | OA08276A (ko) |
| PH (1) | PH22393A (ko) |
| SU (1) | SU1586512A3 (ko) |
| TN (1) | TNSN86056A1 (ko) |
| ZA (1) | ZA862766B (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8524024D0 (en) * | 1985-09-30 | 1985-11-06 | Shell Int Research | Preparation of azetidine-3-carboxylic acid |
| DE69722538T2 (de) * | 1996-09-06 | 2004-04-29 | Sumitomo Chemical Co., Ltd. | Verfahren zur Herstellung von optisch aktiver Azetidin-2-Carbonsäure |
| DE69811893T2 (de) * | 1997-04-24 | 2003-11-27 | Kaneka Corp | Verfahren zur herstellung von azetidin-2-carbonsäure und zwischenprodukten davon |
| DE10117222B4 (de) | 2001-04-06 | 2004-12-30 | Goldschmidt Ag | Verfahren zur Herstellung von Glycinderivaten |
| WO2002088298A1 (en) * | 2001-04-27 | 2002-11-07 | The Procter & Gamble Company | Compounds, compositions, and methods for controlling biofilms |
| PT1663966E (pt) * | 2003-09-15 | 2007-09-26 | Novartis Ag | Derivados de azetidina 1,3-di-substituídos para utilização como antagonistas do receptor ccr-3 no tratamento de doenças inflamatórias e alérgicas |
| JP5211318B2 (ja) * | 2007-03-28 | 2013-06-12 | 国立大学法人 長崎大学 | α，α−ジ置換環状含窒素化合物の製造方法 |
| CA2686517A1 (en) * | 2007-05-10 | 2008-11-20 | Pfizer Limited | Azetidine derivatives and their use as prostaglandin e2 antagonists |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1169027A (en) * | 1966-11-19 | 1969-10-29 | Beecham Group Ltd | Azetidine Derivatives |
| GB8300860D0 (en) * | 1983-01-13 | 1983-02-16 | Shell Int Research | Azetidine compounds |
| US4496440A (en) * | 1984-06-04 | 1985-01-29 | The Dow Chemical Company | Oxidation of hydrophobic --CH2 OH compounds at oxidized nickel anodes |
| DE3571811D1 (en) * | 1984-06-19 | 1989-08-31 | Shell Int Research | Azetidine derivatives and their preparation |
| GB8415614D0 (en) * | 1984-06-19 | 1984-07-25 | Shell Int Research | Azetidine derivatives |
| GB8415615D0 (en) * | 1984-06-19 | 1984-07-25 | Shell Int Research | Preparing azetidine derivatives |
-
1985
- 1985-04-16 GB GB858509746A patent/GB8509746D0/en active Pending
-
1986
- 1986-04-12 CN CN198686102422A patent/CN86102422A/zh active Pending
- 1986-04-14 HU HU861559A patent/HU201303B/hu not_active IP Right Cessation
- 1986-04-14 PH PH33647A patent/PH22393A/en unknown
- 1986-04-14 ES ES553949A patent/ES8707494A1/es not_active Expired
- 1986-04-14 KR KR1019860002829A patent/KR860008134A/ko not_active Application Discontinuation
- 1986-04-14 IL IL78491A patent/IL78491A/xx unknown
- 1986-04-14 DD DD86289076A patent/DD244552A5/de not_active IP Right Cessation
- 1986-04-14 SU SU864027253A patent/SU1586512A3/ru active
- 1986-04-14 OA OA58831A patent/OA08276A/xx unknown
- 1986-04-14 DK DK169386A patent/DK169386A/da not_active IP Right Cessation
- 1986-04-14 GR GR860978A patent/GR860978B/el unknown
- 1986-04-14 AU AU56064/86A patent/AU584412B2/en not_active Ceased
- 1986-04-14 NZ NZ215815A patent/NZ215815A/xx unknown
- 1986-04-14 JP JP61084413A patent/JPS61238991A/ja active Pending
- 1986-04-14 NO NO861447A patent/NO861447L/no unknown
- 1986-04-14 ZA ZA862766A patent/ZA862766B/xx unknown
- 1986-04-14 BR BR8601677A patent/BR8601677A/pt unknown
- 1986-04-15 EP EP86200639A patent/EP0199413A3/en not_active Withdrawn
- 1986-04-16 TN TNTNSN86056A patent/TNSN86056A1/fr unknown
- 1986-04-16 US US06/852,857 patent/US4778577A/en not_active Expired - Lifetime
-
1988
- 1988-06-09 US US07/204,479 patent/US4855452A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU5606486A (en) | 1986-10-23 |
| US4778577A (en) | 1988-10-18 |
| DK169386D0 (da) | 1986-04-14 |
| HUT42755A (en) | 1987-08-28 |
| ES553949A0 (es) | 1987-08-01 |
| ZA862766B (en) | 1986-11-26 |
| ES8707494A1 (es) | 1987-08-01 |
| SU1586512A3 (ru) | 1990-08-15 |
| CN86102422A (zh) | 1987-01-28 |
| IL78491A0 (en) | 1986-08-31 |
| PH22393A (en) | 1988-08-12 |
| HU201303B (en) | 1990-10-28 |
| JPS61238991A (ja) | 1986-10-24 |
| EP0199413A2 (en) | 1986-10-29 |
| AU584412B2 (en) | 1989-05-25 |
| IL78491A (en) | 1989-03-31 |
| NZ215815A (en) | 1989-07-27 |
| DD244552A5 (de) | 1987-04-08 |
| GB8509746D0 (en) | 1985-05-22 |
| GR860978B (en) | 1986-08-06 |
| US4855452A (en) | 1989-08-08 |
| NO861447L (no) | 1986-10-17 |
| DK169386A (da) | 1986-10-17 |
| BR8601677A (pt) | 1986-12-16 |
| EP0199413A3 (en) | 1987-05-06 |
| OA08276A (en) | 1987-10-30 |
| TNSN86056A1 (fr) | 1990-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| WITB | Written withdrawal of application |