KR860004039A - 9-클로로-1,5-벤조티아제핀 유도체의 제조방법 - Google Patents

9-클로로-1,5-벤조티아제핀 유도체의 제조방법 Download PDF

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Publication number
KR860004039A
KR860004039A KR1019850008578A KR850008578A KR860004039A KR 860004039 A KR860004039 A KR 860004039A KR 1019850008578 A KR1019850008578 A KR 1019850008578A KR 850008578 A KR850008578 A KR 850008578A KR 860004039 A KR860004039 A KR 860004039A
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compound
formula
pharmaceutically acceptable
sup
acid addition
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KR1019850008578A
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KR890003600B1 (ko
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미끼오 다께다 (외 3)
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마쯔바라 이찌로
다나베세이야꾸 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

9-클로로-1,5-벤조티아제핀 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 일반식(II)의 화합물 또는 이의 염을 하기 일반식(III)의 화합물 또는 이의 염과 축합시키고, 필요시 생성물을 약학적으로 허용되는 이의 산 부가염으로 전환시킴을 특징으로 하여 하기 일반식(I)의 1,5-벤조티아제핀 유도체 또는 약학적으로 허용되는 이의 산 부가염을 제조하는 방법.
    상기식에서, R1은 수소, 또는 저급 알킬노일이고, R2및 R3는 각각 저급 알킬이며, X는 할로겐이다.
  2. 제1항에 있어서, R1이 수소 또는 탄소수 2 내지 5의 알카노일이고, R2및 R2가 각각 탄소수 1 내지 4의 알킬인 방법.
  3. 제2항에 있어서, R1이 수소 또는 아세틸이고, R2및 R3가 메틸인 방법.
  4. 제1항, 제2항 또는 제3항에 있어서, 일반식(I)화합물이 시스 이성체인 방법.
  5. 제1항, 제2항 또는 제3항에 있어서, 일반식(I)화합물이 (+)-시스 이성체인 방법.
  6. 제5항에 있어서, 일반식(I) 화합물의 (+)-시스 이성체가(+)-시스-2-(4-메톡시페닐)-3-하이드록시-5-[2-(디메틸아미노)에틸]-9-클로로-2,3-디하이드로-1,5-벤조티아제핀-4(5H)-온 또는 이의 약학적으로 허용되는 산 부가염인 방법.
  7. 제5항에 있어서, 일반식(I) 화합물의 (+)-시스 이성체가 (+)-시스-2-(4-메톡시페닐)-3-아세톡시-5-[2-(디메틸아미노)에틸]-9-클로로-2,3-디하이드로-1,5-벤조티아제핀-4(5H)-온 또는 이의 약학적으로 허용되는 산 부가염인 방법.
  8. 하기 일반식(I-a)의 화합물 또는 이의 염을 하기 일반식(IV)의 저급 알카노산 또는 이의 반응성 유도체로 아실화시키고, 필요시 생성물을 이의 약학적으로 허용되는 산 부가염으로 전환시킴을 특징으로 하여 일반식(I-b)의 1,5-벤조티아제핀 유도체를 제조하는 방법.
    상기 식에서, R2, R3및 R4는 각각 저급 알킬이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850008578A 1984-11-17 1985-11-16 9-클로로-1,5-벤조티아제핀 유도체의 제조방법 KR890003600B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8429102 1984-11-17
GB08429102A GB2167063A (en) 1984-11-17 1984-11-17 6 or 9-chloro-1, 5-benzothiazepine derivatives
CN85101892A CN85101892B (zh) 1984-11-17 1985-04-01 制备新型的1，5-苯并硫杂吖庚因衍生物的方法

Publications (2)

Publication Number Publication Date
KR860004039A true KR860004039A (ko) 1986-06-16
KR890003600B1 KR890003600B1 (ko) 1989-09-27

Family

ID=25741514

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850008578A KR890003600B1 (ko) 1984-11-17 1985-11-16 9-클로로-1,5-벤조티아제핀 유도체의 제조방법

Country Status (18)

Country Link
US (1) US4665068A (ko)
EP (1) EP0182273B1 (ko)
JP (1) JPS61122281A (ko)
KR (1) KR890003600B1 (ko)
CN (2) CN85101892B (ko)
AT (1) ATE40997T1 (ko)
AU (1) AU578755B2 (ko)
BG (2) BG44379A3 (ko)
CA (1) CA1226281A (ko)
DD (2) DD239202A5 (ko)
DE (1) DE3568428D1 (ko)
DK (1) DK171821B1 (ko)
ES (2) ES8704914A1 (ko)
GB (1) GB2167063A (ko)
HU (1) HU193834B (ko)
NO (1) NO163488C (ko)
PH (1) PH23328A (ko)
PT (1) PT81504B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2038668T3 (es) * 1986-08-20 1993-08-01 Mcneilab, Inc. Vasodilatadores de benzotiazepina dotados de sustitucion aralquilica.
IE61939B1 (en) * 1987-07-31 1994-11-30 Tanabe Seiyaku Co Naphthothiazepine derivatives and a process for preparing the same
JPS6450872A (en) * 1987-08-21 1989-02-27 Tanabe Seiyaku Co Production of 1,5-benzothiazepine derivative
JPH01128974A (ja) * 1987-11-13 1989-05-22 Tanabe Seiyaku Co Ltd １，５−ベンゾチアゼピン誘導体の製法
FR2630107B1 (fr) * 1988-04-19 1990-06-08 Synthelabo Procede de preparation du (+) - (2s,3s) (amino-2 phenyl)thio)-3 hydroxy-2 (methoxy-4 phenyl)-3 propionate de methyle
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
FR2637285B1 (fr) * 1988-10-03 1991-04-12 Synthelabo Procede de preparation de derives de l'acide propionique et produits obtenus
IT1230057B (it) * 1989-04-13 1991-09-27 Zambon Spa Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
US5057513A (en) * 1989-05-25 1991-10-15 Fujisawa Pharmaceutical Co., Ltd. Spiro-thiazepine derivatives useful as paf antagonists
US5001236A (en) * 1989-11-22 1991-03-19 Marion Laboratories, Inc. Benzothiazepines
IT1240651B (it) * 1990-05-17 1993-12-17 Zambon Spa Processo per la risoluzione di derivati glicidici
IT1302261B1 (it) 1998-09-24 2000-09-05 Zambon Spa Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB296070A (en) * 1927-03-14 1929-04-12 Ass Telephone & Telegraph Co Improvements in or relating to telephone systems
US3075967A (en) * 1961-06-12 1963-01-29 Olin Mathieson Benzothiazines
US3341519A (en) * 1965-04-28 1967-09-12 Squibb & Sons Inc Novel benzoxazines, benzothiazines, benzoxazepins and benzothiazepins
GB1236467A (en) * 1967-10-28 1971-06-23 Tanabe Seiyaku Co Benzothiazepine derivatives
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
KR870000906B1 (ko) * 1982-09-16 1987-05-06 더 뱁콕 앤드 윌콕스 캄패니 과립 제조 기구용 제어장치
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
IT1206505B (it) * 1983-07-22 1989-04-27 Schiapparelli Farma Nuovi derivati benzotiazepinonici, metodo per la loro preparazione e composizioni farmaceutiche che licontengono.
US4585768A (en) * 1984-04-10 1986-04-29 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and processes for preparing the same

Also Published As

Publication number Publication date
DE3568428D1 (en) 1989-04-06
PH23328A (en) 1989-07-14
CN85101892B (zh) 1988-03-02
PT81504B (pt) 1987-11-11
DK530685D0 (da) 1985-11-15
AU578755B2 (en) 1988-11-03
ES548898A0 (es) 1987-04-16
DK171821B1 (da) 1997-06-23
GB8429102D0 (en) 1984-12-27
ES8707723A1 (es) 1987-08-16
EP0182273A1 (en) 1986-05-28
GB2167063A (en) 1986-05-21
AU4933185A (en) 1986-05-22
ATE40997T1 (de) 1989-03-15
NO163488C (no) 1990-06-13
ES557079A0 (es) 1987-08-16
BG44709A3 (ko) 1989-01-16
DK530685A (da) 1986-05-18
US4665068A (en) 1987-05-12
ES8704914A1 (es) 1987-04-16
JPS61122281A (ja) 1986-06-10
NO854565L (no) 1986-05-20
DD239202A5 (de) 1986-09-17
BG44379A3 (en) 1988-11-15
KR890003600B1 (ko) 1989-09-27
NO163488B (no) 1990-02-26
CN85101892A (zh) 1987-01-17
HU193834B (en) 1987-12-28
JPH0459313B2 (ko) 1992-09-21
CA1226281A (en) 1987-09-01
DD249271A5 (de) 1987-09-02
EP0182273B1 (en) 1989-03-01
CN85108458B (zh) 1988-05-25
HUT41804A (en) 1987-05-28
PT81504A (en) 1985-12-01
CN85108458A (zh) 1986-07-30

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