KR860002501A - 신규화합물의 제조방법 - Google Patents
신규화합물의 제조방법 Download PDFInfo
- Publication number
- KR860002501A KR860002501A KR1019850006298A KR850006298A KR860002501A KR 860002501 A KR860002501 A KR 860002501A KR 1019850006298 A KR1019850006298 A KR 1019850006298A KR 850006298 A KR850006298 A KR 850006298A KR 860002501 A KR860002501 A KR 860002501A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- group
- precursor
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 title claims 50
- 238000002360 preparation method Methods 0.000 title claims 4
- 239000002243 precursor Substances 0.000 claims 11
- 238000006243 chemical reaction Methods 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 239000007795 chemical reaction product Substances 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- WPWUFUBLGADILS-WDSKDSINSA-N Ala-Pro Chemical compound C[C@H](N)C(=O)N1CCC[C@H]1C(O)=O WPWUFUBLGADILS-WDSKDSINSA-N 0.000 claims 1
- 108010087924 alanylproline Proteins 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000003862 amino acid derivatives Chemical class 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 1
- 238000003475 lamination Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- -1 nitro, amino, carboxy Chemical group 0.000 claims 1
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 125000005310 triazolidinyl group Chemical group N1(NNCC1)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848422165A GB8422165D0 (en) | 1984-09-01 | 1984-09-01 | Compounds |
| GB8422165 | 1984-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR860002501A true KR860002501A (ko) | 1986-04-26 |
Family
ID=10566163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850006298A Ceased KR860002501A (ko) | 1984-09-01 | 1985-08-30 | 신규화합물의 제조방법 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0174162A3 (enExample) |
| JP (1) | JPS6183198A (enExample) |
| KR (1) | KR860002501A (enExample) |
| AU (1) | AU581455B2 (enExample) |
| CS (1) | CS621585A2 (enExample) |
| DD (1) | DD236522A5 (enExample) |
| DK (1) | DK396885A (enExample) |
| ES (6) | ES8703418A1 (enExample) |
| FI (1) | FI853336L (enExample) |
| GB (1) | GB8422165D0 (enExample) |
| GR (1) | GR852113B (enExample) |
| HU (1) | HUT39190A (enExample) |
| MC (1) | MC1695A1 (enExample) |
| PL (3) | PL265522A1 (enExample) |
| PT (1) | PT81055B (enExample) |
| ZA (1) | ZA856672B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT46045A (en) * | 1986-02-28 | 1988-09-28 | Wellcome Found | Process for producing new compounds and pharmaceutics comprising same |
| EP0237239A3 (en) * | 1986-02-28 | 1988-08-17 | The Wellcome Foundation Limited | New compounds |
| US5036051A (en) * | 1987-10-06 | 1991-07-30 | Abbott Laboratories | Glaucoma treatment |
| US4927807A (en) * | 1987-10-06 | 1990-05-22 | Abbott Laboratories | Glaucoma treatment |
| US5346887A (en) * | 1987-10-06 | 1994-09-13 | Abbott Laboratories | Glaucoma treatment |
| US5025001A (en) * | 1988-06-15 | 1991-06-18 | Brigham And Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
| US5187183A (en) * | 1988-06-15 | 1993-02-16 | Brigham & Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
| US5356890A (en) * | 1988-06-15 | 1994-10-18 | Brigham And Women's Hospital | S-nitroso derivatives of ace inhibitors and the use thereof |
| US5059589A (en) * | 1988-09-08 | 1991-10-22 | Abbott Laboratories | Glaucoma treatment |
| US4916129A (en) * | 1989-01-19 | 1990-04-10 | E. I. Du Pont De Nemours And Company | Combination β-blocking/angiotensin II blocking antihypertensives |
| US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
| US9259535B2 (en) | 2006-06-22 | 2016-02-16 | Excelsior Medical Corporation | Antiseptic cap equipped syringe |
| US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
| US10166381B2 (en) | 2011-05-23 | 2019-01-01 | Excelsior Medical Corporation | Antiseptic cap |
| ES2797649T3 (es) | 2011-07-12 | 2020-12-03 | Icu Medical Inc | Dispositivo para entrega de agente antimicrobiano en un catéter transdérmico |
| EP3137122B1 (en) | 2014-05-02 | 2019-09-04 | Excelsior Medical Corporation | Strip package for antiseptic cap |
| WO2016182822A1 (en) | 2015-05-08 | 2016-11-17 | Icu Medical, Inc. | Medical connectors configured to receive emitters of therapeutic agents |
| CA3040277C (en) | 2016-10-14 | 2025-08-12 | Icu Medical Inc | Sanitizing caps for medical connectors |
| WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
| US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
| US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
| US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
| US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
| US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
| US11433215B2 (en) | 2018-11-21 | 2022-09-06 | Icu Medical, Inc. | Antimicrobial device comprising a cap with ring and insert |
| AU2021396147A1 (en) | 2020-12-07 | 2023-06-29 | Icu Medical, Inc. | Peritoneal dialysis caps, systems and methods |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3705907A (en) * | 1970-02-19 | 1972-12-12 | Sandoz Ltd | 4-(2-hydroxy)-3-aminopropoxy)-indole derivatives |
| IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| EP0046953B1 (de) * | 1980-08-30 | 1989-12-06 | Hoechst Aktiengesellschaft | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung |
| GR75019B (enExample) * | 1980-09-17 | 1984-07-12 | Univ Miami | |
| US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| US4462943A (en) * | 1980-11-24 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Carboxyalkyl amino acid derivatives of various substituted prolines |
| EP0080822A1 (en) * | 1981-11-27 | 1983-06-08 | Beecham Group Plc | Anti-hypertensive prolinol-based peptides |
| IE55867B1 (en) * | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
| EP0088350B1 (en) * | 1982-03-08 | 1985-02-20 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
| AU560285B2 (en) * | 1982-07-19 | 1987-04-02 | Imperial Chemical Industries Plc | Heterocyclyl carbonyl sulphonamides |
-
1984
- 1984-09-01 GB GB848422165A patent/GB8422165D0/en active Pending
-
1985
- 1985-08-22 MC MC851792A patent/MC1695A1/fr unknown
- 1985-08-30 FI FI853336A patent/FI853336L/fi not_active Application Discontinuation
- 1985-08-30 ES ES546595A patent/ES8703418A1/es not_active Expired
- 1985-08-30 JP JP60191817A patent/JPS6183198A/ja active Pending
- 1985-08-30 PL PL1985265522A patent/PL265522A1/xx unknown
- 1985-08-30 PL PL1985265523A patent/PL265523A1/xx unknown
- 1985-08-30 DD DD85280184A patent/DD236522A5/de not_active IP Right Cessation
- 1985-08-30 AU AU46932/85A patent/AU581455B2/en not_active Expired - Fee Related
- 1985-08-30 CS CS856215A patent/CS621585A2/cs unknown
- 1985-08-30 EP EP85306144A patent/EP0174162A3/en not_active Withdrawn
- 1985-08-30 PT PT81055A patent/PT81055B/pt unknown
- 1985-08-30 PL PL25519285A patent/PL255192A1/xx unknown
- 1985-08-30 DK DK396885A patent/DK396885A/da not_active Application Discontinuation
- 1985-08-30 KR KR1019850006298A patent/KR860002501A/ko not_active Ceased
- 1985-08-30 ZA ZA856672A patent/ZA856672B/xx unknown
- 1985-08-30 GR GR852113A patent/GR852113B/el unknown
- 1985-08-30 HU HU853304A patent/HUT39190A/hu unknown
-
1986
- 1986-04-01 ES ES553612A patent/ES8801312A1/es not_active Expired
- 1986-04-01 ES ES553610A patent/ES8801310A1/es not_active Expired
- 1986-04-01 ES ES553611A patent/ES8801311A1/es not_active Expired
- 1986-04-01 ES ES553614A patent/ES8801672A1/es not_active Expired
- 1986-04-01 ES ES553613A patent/ES8801313A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CS621585A2 (en) | 1989-08-14 |
| ES553614A0 (es) | 1988-02-16 |
| ES8801313A1 (es) | 1988-01-01 |
| PL255192A1 (en) | 1987-09-21 |
| ES553612A0 (es) | 1987-12-16 |
| PL265523A1 (en) | 1988-02-04 |
| EP0174162A2 (en) | 1986-03-12 |
| ES8801311A1 (es) | 1987-12-16 |
| FI853336A7 (fi) | 1986-03-02 |
| PT81055A (en) | 1985-09-01 |
| ES8801312A1 (es) | 1987-12-16 |
| GB8422165D0 (en) | 1984-10-03 |
| FI853336A0 (fi) | 1985-08-30 |
| EP0174162A3 (en) | 1988-07-27 |
| DK396885A (da) | 1986-03-02 |
| DK396885D0 (da) | 1985-08-30 |
| FI853336L (fi) | 1986-03-02 |
| AU4693285A (en) | 1986-03-06 |
| MC1695A1 (fr) | 1986-07-18 |
| HUT39190A (en) | 1986-08-28 |
| PL265522A1 (en) | 1988-05-12 |
| ES546595A0 (es) | 1987-02-16 |
| JPS6183198A (ja) | 1986-04-26 |
| ES553610A0 (es) | 1988-01-01 |
| ES8703418A1 (es) | 1987-02-16 |
| DD236522A5 (de) | 1986-06-11 |
| ES553613A0 (es) | 1988-01-01 |
| ZA856672B (en) | 1987-05-27 |
| AU581455B2 (en) | 1989-02-23 |
| GR852113B (enExample) | 1985-12-24 |
| PT81055B (en) | 1987-07-02 |
| ES8801672A1 (es) | 1988-02-16 |
| ES8801310A1 (es) | 1988-01-01 |
| ES553611A0 (es) | 1987-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR860002501A (ko) | 신규화합물의 제조방법 | |
| EP0486268B1 (en) | A method for preparing 4-hydroxystyrene | |
| Rinehart Jr et al. | Acyl-from alkyl-ferrocenes by manganese dioxide oxidation. Ferrocobenzoquinone | |
| US3869347A (en) | Process for the production of new pepstatins having anti-pepsin activity | |
| AU680096B2 (en) | Process for preparing N-substituted glycinic acids or glycine esters and use of said process in indigo synthesis | |
| KR870007881A (ko) | 신규 알킬렌디아민 유도체의 제조방법 | |
| KR920004411A (ko) | 히드록시에틸아민 및 노르스타틴계 포스포네이트- 함유 유사펩티드 | |
| US5922873A (en) | Process for preparing N-tert-butyl-2-pyrazinecarboxamide and N-tert-butyl-2-piperazinecarboxamide | |
| Teramoto et al. | Optically active N-hydroxytartrimides for enantioselective peptide synthesis | |
| KR850004396A (ko) | 네오카르지노스타틴 유도체의 제조방법 | |
| KR0163042B1 (ko) | 4-아미노-5-헥센산의 제조방법 | |
| US3646222A (en) | Method for production of substituted hydroquinones | |
| Normant et al. | Organobismetallic zinc reagents: Their preparation and use in diastereoselective reactions | |
| JPH0768163B2 (ja) | シクロペンテノン誘導体の製法 | |
| AU635908B2 (en) | 2-aminocarboxylic acid derivatives, their manufacture and use as drugs | |
| US3975366A (en) | Process for the production of new pepstatins having anti-pepsin activity | |
| JPS6261965A (ja) | ビス（２−グルコンアミドアルキル）ジスルフイド | |
| CN111499548B (zh) | 一种在脂肪胺和脂肪醇的β位高效引入乙酰氧基的方法 | |
| Akita et al. | One-pot synthesis of transition metal-substituted carboxylic acids | |
| JPS62258346A (ja) | Ｎ，ｎ−ジアルキルアミノフエノ−ル類の製造方法 | |
| US2932648A (en) | Nicotinamide process | |
| KR870007883A (ko) | 신규 약제 화합물의 제조방법 | |
| JPS6168472A (ja) | 不飽和ヒダントインの製造方法 | |
| KR910009635A (ko) | 글루타르산 유도체 및 이의 제조방법 | |
| Shiba et al. | Synthesis of l-thyroxine from 3, 5-diiodo-l-tyrosine by nonenzymic transamination |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19850830 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19870929 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19850830 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19900926 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19901217 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19900926 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |