KR850007070A - 락투로오즈의 정제방법 - Google Patents
락투로오즈의 정제방법 Download PDFInfo
- Publication number
- KR850007070A KR850007070A KR1019850001851A KR850001851A KR850007070A KR 850007070 A KR850007070 A KR 850007070A KR 1019850001851 A KR1019850001851 A KR 1019850001851A KR 850001851 A KR850001851 A KR 850001851A KR 850007070 A KR850007070 A KR 850007070A
- Authority
- KR
- South Korea
- Prior art keywords
- resin
- solution
- lactose
- lacturose
- general formula
- Prior art date
Links
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 title claims description 5
- 239000008101 lactose Substances 0.000 title claims description 5
- 239000011347 resin Substances 0.000 claims description 10
- 229920005989 resin Polymers 0.000 claims description 10
- 150000001720 carbohydrates Chemical class 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 3
- 229910052796 boron Inorganic materials 0.000 claims 3
- 235000014633 carbohydrates Nutrition 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 239000004793 Polystyrene Substances 0.000 claims 2
- 229930182830 galactose Natural products 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 239000011260 aqueous acid Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K13/00—Sugars not otherwise provided for in this class
- C13K13/005—Lactulose
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 용액(C2)의 고압액체 크로마토그래피 특성(HPLC)을 나타내는 그래프. 제2도는 동일한 초기 락투로오즈 용액을 브롬으로 처리하고 통상적 방법을 사용한 수지상에 통과시킴으로써 정제시켜 수득한 용액의 HPLC특성을 나타내는 그래프.
Claims (6)
- 5내지 40％의 탄수화물-함유 락투로오즈 수용액을 일반식(Ⅰ)의 이관능화 붕소수지-함유컬럼 하나이상중에 통과시킴을 특징으로 하여, 다른 탄수화물, 특히 락토오즈 및 갈락토오즈로 부터 락투로오즈를 정제하는 방법.상기식에서, ⓟ는 폴리아크릴계 또는 폴리스티렌 매트릭스이고, R 및 R3는 동일하거나 상에할 수 있으며, -(CH2)n-(여기서 n은 0 내지 5이다)이고, R1및 R2는 동일하거나 상이할 수 있으며, C1-C5알킬이고, X-는 히드록실 및 할라이드 중에서 선택된 음이온이다.
- 제1항에 있어서, 수지 관능화도가 무수수지 g당 B의 1 내지 8meq이고, 암모늄 그룹이 무수수지 g당 2내지 9meq인 방법.
- 제1항에 있어서, 락투로오즈 용액을 폴리아크릴계 매트릭스- 함유 일반식(Ⅰ)의 붕소 수지중에 통과시켜, 선택적으로 락투로오즈를 보유하는 방법.
- 제3항에 있어서, 수지가 보유한 락투로오즈를 pH5이하의 산 수용액으로 용출시켜 언급한 수지로 부터 방출시키는 방법.
- 제4항에 있어서, 용출된 락토오즈--다량 함유 용액을 폴리스티렌 매트릭스-함유 일반식(Ⅰ)의 붕소수지중에 통과시켜, 선택적으로 갈락토오즈를 보유하는 방법.
- 제1항에 있어서, 컬럼중에 함유된 수지부피(ℓ)대 공급된 용액중에 함유된 탄수화물 중량(kg)의 비가 1:0.3 내지 1:2인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20176A/84 | 1984-03-22 | ||
| IT8420176A IT1206140B (it) | 1984-03-22 | 1984-03-22 | Procedimento per la purificazione di lattulosio. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR850007070A true KR850007070A (ko) | 1985-10-30 |
| KR900006229B1 KR900006229B1 (ko) | 1990-08-27 |
Family
ID=11164437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850001851A KR900006229B1 (ko) | 1984-03-22 | 1985-03-21 | 락투로오즈의 정제방법 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4565582A (ko) |
| EP (1) | EP0158148B1 (ko) |
| JP (1) | JPS60209596A (ko) |
| KR (1) | KR900006229B1 (ko) |
| AT (1) | ATE34773T1 (ko) |
| CA (1) | CA1223254A (ko) |
| DE (1) | DE3563067D1 (ko) |
| DK (1) | DK127485A (ko) |
| GB (1) | GB2155933B (ko) |
| IT (1) | IT1206140B (ko) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1223398B (it) * | 1987-12-01 | 1990-09-19 | Sirac Spa | Procedimento per la preparazione di lattulosio cristallino ad alta purezza |
| IT1224438B (it) * | 1987-12-30 | 1990-10-04 | Sirac Srl | Processo per l'ottenimento di sciroppi di lattulosio ad elevata purezza e sciroppo cosi' ottenuto |
| JPH0219319A (ja) * | 1988-05-26 | 1990-01-23 | Duphar Internatl Res Bv | ラクツロースシロップから単離したフラクション及びこれを有効成分とする抗内毒素作用を有する医薬組成物 |
| EP0375046B1 (en) * | 1988-12-21 | 1994-04-13 | Duphar International Research B.V | Method of manufacturing lactulose |
| IT1271449B (it) * | 1993-04-28 | 1997-05-28 | Inalco Spa | Procedimento per la preparazione di lattulosio cristallino da sciroppi commerciali |
| GB9401603D0 (en) * | 1994-01-27 | 1994-03-23 | Univ Strathclyde | Purification of plant-derived polynucleotides |
| CN110088146B (zh) * | 2016-12-30 | 2023-06-27 | 陶氏环球技术有限责任公司 | 树脂珠以及在水性溶液的处理中的用途 |
| BR112019012117B1 (pt) * | 2016-12-30 | 2022-08-16 | Dow Global Technologies Llc | Método de processamento de uma solução aquosa |
| CN111454305A (zh) * | 2020-05-25 | 2020-07-28 | 苏州福赛思生物科技有限公司 | 一种利用苯硼酸基载体定向辅助乳糖异构化制备并分离纯化乳果糖的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2818851A (en) * | 1956-02-07 | 1958-01-07 | Joseph X Khym | Separation and analysis of polyhydroxy substances |
| GB865594A (en) * | 1956-03-10 | 1961-04-19 | Tervalon Nv | Improvements in or relating to producing crystalline lactulose |
| US3546206A (en) * | 1967-09-20 | 1970-12-08 | Kraftco Corp | Method of making lactulose |
| US3505309A (en) * | 1967-09-25 | 1970-04-07 | Research Corp | Process for lactulose |
| US3562012A (en) * | 1967-11-07 | 1971-02-09 | Boehringer Mannheim Gmbh | Process for the preparation of pure lactulose from crude lactulosate syrups |
| JPS522984B1 (ko) * | 1971-05-22 | 1977-01-25 | ||
| JPS4944331B1 (ko) * | 1971-05-31 | 1974-11-27 | ||
| DE2229208A1 (de) * | 1972-06-15 | 1974-01-03 | Boehringer Mannheim Gmbh | Verfahren zur trennung von zuckern |
| JPS5271409A (en) * | 1975-12-10 | 1977-06-14 | Toray Ind Inc | Separation of saccharides |
| IT1099668B (it) * | 1978-09-29 | 1985-09-28 | Molteni L & C Dei Filli Alitti | Processo per la produzione di lattulosio |
| JPS5566525A (en) * | 1978-11-14 | 1980-05-20 | Nippon Koonsutaac Kk | Fractionation of compound having cis-type diol structure |
| JPS5711993A (en) * | 1980-05-27 | 1982-01-21 | Eru Moruteni Ando Shii Dei Efu | Manufacture of lactulose |
-
1984
- 1984-03-22 IT IT8420176A patent/IT1206140B/it active
- 1984-07-16 US US06/631,105 patent/US4565582A/en not_active Expired - Fee Related
- 1984-07-17 GB GB08418207A patent/GB2155933B/en not_active Expired
- 1984-07-26 CA CA000459797A patent/CA1223254A/en not_active Expired
-
1985
- 1985-03-14 AT AT85102933T patent/ATE34773T1/de not_active IP Right Cessation
- 1985-03-14 DE DE8585102933T patent/DE3563067D1/de not_active Expired
- 1985-03-14 EP EP85102933A patent/EP0158148B1/en not_active Expired
- 1985-03-21 KR KR1019850001851A patent/KR900006229B1/ko not_active IP Right Cessation
- 1985-03-21 DK DK127485A patent/DK127485A/da not_active Application Discontinuation
- 1985-03-22 JP JP60055747A patent/JPS60209596A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB8418207D0 (en) | 1984-08-22 |
| DE3563067D1 (en) | 1988-07-07 |
| JPH0545599B2 (ko) | 1993-07-09 |
| KR900006229B1 (ko) | 1990-08-27 |
| CA1223254A (en) | 1987-06-23 |
| IT8420176A0 (it) | 1984-03-22 |
| GB2155933A (en) | 1985-10-02 |
| DK127485A (da) | 1985-09-23 |
| GB2155933B (en) | 1988-02-24 |
| US4565582A (en) | 1986-01-21 |
| JPS60209596A (ja) | 1985-10-22 |
| IT1206140B (it) | 1989-04-14 |
| EP0158148A1 (en) | 1985-10-16 |
| DK127485D0 (da) | 1985-03-21 |
| EP0158148B1 (en) | 1988-06-01 |
| ATE34773T1 (de) | 1988-06-15 |
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Legal Events
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| A201 | Request for examination | ||
| N231 | Notification of change of applicant | ||
| G160 | Decision to publish patent application | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| LAPS | Lapse due to unpaid annual fee |