KR880009635A - r-글로불린 주사용 용액 - Google Patents

r-글로불린 주사용 용액 Download PDF

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Publication number
KR880009635A
KR880009635A KR1019880001059A KR880001059A KR880009635A KR 880009635 A KR880009635 A KR 880009635A KR 1019880001059 A KR1019880001059 A KR 1019880001059A KR 880001059 A KR880001059 A KR 880001059A KR 880009635 A KR880009635 A KR 880009635A
Authority
KR
South Korea
Prior art keywords
solution
globulin
intravenous
injectable solution
use according
Prior art date
Application number
KR1019880001059A
Other languages
English (en)
Other versions
KR960008653B1 (ko
Inventor
유타까 히라오
카주오 타께찌
가투히로 우리유
야히로 우에무라
Original Assignee
마쓰시다 렌죠
가부시끼가이샤 미도리 쥬지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 마쓰시다 렌죠, 가부시끼가이샤 미도리 쥬지 filed Critical 마쓰시다 렌죠
Publication of KR880009635A publication Critical patent/KR880009635A/ko
Application granted granted Critical
Publication of KR960008653B1 publication Critical patent/KR960008653B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Abstract

내용 없음.

Description

r-글로불린 주사용 용액
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 안정화제로서 솔비톨을 함유하며, 전기 전도도가 낮고, pH 가 약 5.5±0.2임을 특징으로 하는, 완전한 분자구조를 갖는 화학적으로 변형되지 않은 r-글로블린의 정맥 주사용용액.
  2. 제1항에 있어서, r-글로불린의 95중량% 이상이 r-글로불린 단량체인 정맥 주사용 용액.
  3. 제1항에 있어서, 8℃에서 측정한 전기 전도도가 1mmho 이하인 정맥 주사용 용액.
  4. 제1항에 있어서, 8℃에서 측정한 전기 전도도가 0.6mmho 이하인 정맥 주사용 용액.
  5. 제1항에 있어서, 솔비톨이 1 내지 20W/V%의 농도로 존재하는 정맥 주사용 용액.
  6. 제1항에 있어서, 솔비톨이 2 내지 10W/V%의 농도로 존재하는 정맥 주사용 용액.
  7. 제1항에 있어서, pH 가 약 5.5인 정맥주사용 용액.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880001059A 1987-02-06 1988-02-05 γ-글로불린 주사용 액상 제제 KR960008653B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62027031A JP2547556B2 (ja) 1987-02-06 1987-02-06 ｒ−グロブリンの液状製剤
JP27031/87 1987-02-06
JP62-27031 1987-02-06

Publications (2)

Publication Number Publication Date
KR880009635A true KR880009635A (ko) 1988-10-04
KR960008653B1 KR960008653B1 (ko) 1996-06-28

Family

ID=12209701

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880001059A KR960008653B1 (ko) 1987-02-06 1988-02-05 γ-글로불린 주사용 액상 제제

Country Status (7)

Country Link
US (1) US4876088A (ko)
EP (1) EP0278422B1 (ko)
JP (1) JP2547556B2 (ko)
KR (1) KR960008653B1 (ko)
CA (1) CA1331135C (ko)
DE (1) DE3889938T2 (ko)
ES (1) ES2052615T3 (ko)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945098A (en) * 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
US5258177A (en) * 1991-12-10 1993-11-02 Alpha Therapeutic Corporation IgA preparation and process of making the same
JPH07238036A (ja) * 1994-02-28 1995-09-12 Green Cross Corp:The 静注用グロブリン液状組成物のグロブリン二量体増加抑制方法
ES2091161B1 (es) * 1995-04-12 1997-05-16 Grifols Grupo Sa Procedimiento para la produccion de gammaglobulina intramuscular inactivada por pasteurizacion.
US5837519A (en) * 1996-11-21 1998-11-17 Bayer Corporation Dry-heat viral inactivation under controlled moisture conditions
CA2232420A1 (en) * 1997-03-19 1998-09-19 The Green Cross Corporation Immunoglobulin preparation and preparation process thereof
WO1998044948A2 (en) * 1997-04-07 1998-10-15 Cangene Corporation Intravenous immune globulin formulation containing a non-ionic surface active agent with improved pharmacokinetic properties
US6159471A (en) 1997-10-23 2000-12-12 Yoshitomi Pharmaceutical Industries, Ltd. Room temperature storable immunoglobulin preparation for intravenous injection
JP4685238B2 (ja) * 1998-06-09 2011-05-18 ツエー・エス・エル・ベーリング・アクチエンゲゼルシヤフト 静脈投与用免疫グロブリン及び他の免疫グロブリン生成物の製造法
ES2184594B1 (es) * 2001-01-17 2004-01-01 Probitas Pharma Sa Procedimiento para la produccion de gammaglobulina g humana inactivada de virus.
KR101080021B1 (ko) 2002-02-14 2011-11-04 추가이 세이야쿠 가부시키가이샤 항체함유 용액제제
JP2005320248A (ja) * 2002-04-22 2005-11-17 Mitsubishi Pharma Corp 免疫グロブリン製剤の製造方法
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US20050136055A1 (en) * 2003-12-22 2005-06-23 Pfizer Inc CD40 antibody formulation and methods
ES2553987T3 (es) * 2003-12-25 2015-12-15 Kyowa Hakko Kirin Co., Ltd. Preparación farmacéutica de base acuosa estable que contiene anticuerpo
EP1909831A4 (en) 2005-06-14 2013-02-20 Amgen Inc PREPARATIONS OF SPONTANEOUS TAMPING PROTEINS
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
TWI489994B (zh) 2008-03-17 2015-07-01 Baxter Healthcare Sa 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法
AR078161A1 (es) * 2009-09-11 2011-10-19 Hoffmann La Roche Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
CA2774053C (en) 2009-09-17 2015-04-28 Baxter Healthcare, S.A. Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof
ES2381828B1 (es) 2012-03-20 2012-11-16 Grifols, S.A. PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO
BR112019007858A2 (pt) 2016-10-21 2019-07-02 Amgen Inc formulações farmacêuticas e métodos para produzir as mesmas

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5840532B2 (ja) * 1975-04-08 1983-09-06 カブシキガイシヤ ミドリジユウジ Ｉｇａ オヨビ ｉｇｍ ノネツアンテイカホウ
JPS553721A (en) * 1978-06-21 1980-01-11 Morinaga Milk Ind Co Ltd Production of powder of colostrum
DE3176491D1 (en) * 1980-03-05 1987-11-26 Miles Lab Pasteurized therapeutically active protein compositions
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
JPS56127320A (en) * 1980-03-10 1981-10-06 Mochida Pharmaceut Co Ltd Gamma-globulin pharmaceutical
US4477432A (en) * 1981-05-01 1984-10-16 Cutter Laboratories, Inc. Oral immune globulin
US4396608A (en) * 1981-08-24 1983-08-02 Cutter Laboratories Intravenously injectable immune serum globulin
US4412990A (en) * 1982-07-02 1983-11-01 Cutter Laboratories, Inc. Composition having enhanced opsonic activity
US4439421A (en) * 1982-08-30 1984-03-27 Baxter Travenol Laboratories, Inc. Stabilized gamma globulin concentrate
JPH0669961B2 (ja) * 1984-09-25 1994-09-07 株式会社ミドリ十字 免疫グロブリンの加熱処理方法
JPH07103045B2 (ja) * 1986-07-09 1995-11-08 株式会社ミドリ十字 非化学修飾γ−グロブリンの加熱処理方法
CA1310267C (en) * 1986-07-09 1992-11-17 Yutaka Hirao Process for heat treating chemically unmodified _-globulin

Also Published As

Publication number Publication date
DE3889938T2 (de) 1994-11-03
EP0278422B1 (en) 1994-06-08
US4876088A (en) 1989-10-24
DE3889938D1 (de) 1994-07-14
JPS63192724A (ja) 1988-08-10
CA1331135C (en) 1994-08-02
EP0278422A2 (en) 1988-08-17
ES2052615T3 (es) 1994-07-16
EP0278422A3 (en) 1990-04-04
KR960008653B1 (ko) 1996-06-28
JP2547556B2 (ja) 1996-10-23

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