ES2052615T3 - Soluciones inyectables de gamma-globulina. - Google Patents
Soluciones inyectables de gamma-globulina.Info
- Publication number
- ES2052615T3 ES2052615T3 ES88101689T ES88101689T ES2052615T3 ES 2052615 T3 ES2052615 T3 ES 2052615T3 ES 88101689 T ES88101689 T ES 88101689T ES 88101689 T ES88101689 T ES 88101689T ES 2052615 T3 ES2052615 T3 ES 2052615T3
- Authority
- ES
- Spain
- Prior art keywords
- gamma
- globulin
- injectable solutions
- increase
- injectable solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
LA INVENCION SE REFIERE A UNA SOLUCION INYECTABLE POR VIA INTRAVENOSA DE GAMMA-GLOBULINA NO MODIFICADA QUIMICAMENTE, QUE TIENE ESTRUCTURA MOLECULAR COMPLETA. LA CITADA SOLUCION CONTIENE SORBITOL COMO ESTABILIZANTE Y TIENE UNA CONDUCTIVIDAD ELECTRICA BAJA Y UN PH DE ALREDEDOR DE 5,5 + - 0,2. LA SOLUCION INYECTABLE NO CAUSA INCREMENTO DE GAMMA-GLOBULINA POLIMERA, ELEVACION DEL TITULO DE ANTICOMPLEMENTOS, O EMPEORAMIENTO DE LAS ACTIVIDADES DE GAMMA-GLOBULINA, NI DURANTE LA CONSERVACION NI EN LA ADMINISTRACION A ORGANISMOS VIVOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62027031A JP2547556B2 (ja) | 1987-02-06 | 1987-02-06 | r−グロブリンの液状製剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2052615T3 true ES2052615T3 (es) | 1994-07-16 |
Family
ID=12209701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88101689T Expired - Lifetime ES2052615T3 (es) | 1987-02-06 | 1988-02-05 | Soluciones inyectables de gamma-globulina. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4876088A (es) |
EP (1) | EP0278422B1 (es) |
JP (1) | JP2547556B2 (es) |
KR (1) | KR960008653B1 (es) |
CA (1) | CA1331135C (es) |
DE (1) | DE3889938T2 (es) |
ES (1) | ES2052615T3 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5945098A (en) * | 1990-02-01 | 1999-08-31 | Baxter International Inc. | Stable intravenously-administrable immune globulin preparation |
US5258177A (en) * | 1991-12-10 | 1993-11-02 | Alpha Therapeutic Corporation | IgA preparation and process of making the same |
JPH07238036A (ja) * | 1994-02-28 | 1995-09-12 | Green Cross Corp:The | 静注用グロブリン液状組成物のグロブリン二量体増加抑制方法 |
ES2091161B1 (es) * | 1995-04-12 | 1997-05-16 | Grifols Grupo Sa | Procedimiento para la produccion de gammaglobulina intramuscular inactivada por pasteurizacion. |
US5837519A (en) * | 1996-11-21 | 1998-11-17 | Bayer Corporation | Dry-heat viral inactivation under controlled moisture conditions |
TW541179B (en) * | 1997-03-19 | 2003-07-11 | Green Cross Corp | Process for preparing immunoglobulin preparation |
EP0973549A2 (en) * | 1997-04-07 | 2000-01-26 | Cangene Corporation | Intravenous immune globulin formulation containing a non-ionic surface active agent with improved pharmacokinetic properties |
ATE224203T1 (de) | 1997-10-23 | 2002-10-15 | Mitsubishi Pharma Corp | Bei raumtemperatur lagerfähiges immunoglobolin- präparat für intravenöse injektion |
DK2272870T3 (da) * | 1998-06-09 | 2013-08-05 | Csl Behring Ag | Fremgangsmåde til fremstilling af immunoglobuliner med henblik på intravenøs indgivelse og andre immunoglobulin-lignende produkter. |
ES2184594B1 (es) * | 2001-01-17 | 2004-01-01 | Probitas Pharma Sa | Procedimiento para la produccion de gammaglobulina g humana inactivada de virus. |
EP3192528A1 (en) | 2002-02-14 | 2017-07-19 | Chugai Seiyaku Kabushiki Kaisha | Formulation of anti-il6r antibody-containing solutions comprising a sugar as a stabilizer |
JP2005320248A (ja) * | 2002-04-22 | 2005-11-17 | Mitsubishi Pharma Corp | 免疫グロブリン製剤の製造方法 |
US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
US20050136055A1 (en) * | 2003-12-22 | 2005-06-23 | Pfizer Inc | CD40 antibody formulation and methods |
US20070184050A1 (en) * | 2003-12-25 | 2007-08-09 | Kirin Beer Kabushiki Kaisha | Stable water-based medicinal preparation containing antibody |
EP1909831A4 (en) | 2005-06-14 | 2013-02-20 | Amgen Inc | PREPARATIONS OF SPONTANEOUS TAMPING PROTEINS |
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
TWI532498B (zh) | 2008-03-17 | 2016-05-11 | 巴克斯特保健公司 | 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法 |
AR078161A1 (es) * | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
CN102655853B (zh) * | 2009-09-17 | 2015-07-29 | 巴克斯特卫生保健有限公司 | 透明质酸酶和免疫球蛋白的稳定的复合制剂及其使用方法 |
ES2381828B1 (es) | 2012-03-20 | 2012-11-16 | Grifols, S.A. | PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO |
US20180110856A1 (en) | 2016-10-21 | 2018-04-26 | Amgen Inc. | Pharmaceutical Formulations and Methods of Making the Same |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5840532B2 (ja) * | 1975-04-08 | 1983-09-06 | カブシキガイシヤ ミドリジユウジ | Iga オヨビ igm ノネツアンテイカホウ |
JPS553721A (en) * | 1978-06-21 | 1980-01-11 | Morinaga Milk Ind Co Ltd | Production of powder of colostrum |
US4440679A (en) * | 1980-03-05 | 1984-04-03 | Cutter Laboratories, Inc. | Pasteurized therapeutically active protein compositions |
DE3176491D1 (en) * | 1980-03-05 | 1987-11-26 | Miles Lab | Pasteurized therapeutically active protein compositions |
JPS56127320A (en) * | 1980-03-10 | 1981-10-06 | Mochida Pharmaceut Co Ltd | Gamma-globulin pharmaceutical |
US4477432A (en) * | 1981-05-01 | 1984-10-16 | Cutter Laboratories, Inc. | Oral immune globulin |
US4396608A (en) * | 1981-08-24 | 1983-08-02 | Cutter Laboratories | Intravenously injectable immune serum globulin |
US4412990A (en) * | 1982-07-02 | 1983-11-01 | Cutter Laboratories, Inc. | Composition having enhanced opsonic activity |
US4439421A (en) * | 1982-08-30 | 1984-03-27 | Baxter Travenol Laboratories, Inc. | Stabilized gamma globulin concentrate |
JPH0669961B2 (ja) * | 1984-09-25 | 1994-09-07 | 株式会社ミドリ十字 | 免疫グロブリンの加熱処理方法 |
JPH07103045B2 (ja) * | 1986-07-09 | 1995-11-08 | 株式会社ミドリ十字 | 非化学修飾γ−グロブリンの加熱処理方法 |
CA1310267C (en) * | 1986-07-09 | 1992-11-17 | Yutaka Hirao | Process for heat treating chemically unmodified _-globulin |
-
1987
- 1987-02-06 JP JP62027031A patent/JP2547556B2/ja not_active Expired - Lifetime
-
1988
- 1988-02-04 CA CA000558134A patent/CA1331135C/en not_active Expired - Lifetime
- 1988-02-05 KR KR1019880001059A patent/KR960008653B1/ko not_active IP Right Cessation
- 1988-02-05 US US07/152,717 patent/US4876088A/en not_active Expired - Lifetime
- 1988-02-05 ES ES88101689T patent/ES2052615T3/es not_active Expired - Lifetime
- 1988-02-05 DE DE3889938T patent/DE3889938T2/de not_active Expired - Lifetime
- 1988-02-05 EP EP88101689A patent/EP0278422B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3889938T2 (de) | 1994-11-03 |
CA1331135C (en) | 1994-08-02 |
EP0278422B1 (en) | 1994-06-08 |
US4876088A (en) | 1989-10-24 |
EP0278422A3 (en) | 1990-04-04 |
EP0278422A2 (en) | 1988-08-17 |
KR880009635A (ko) | 1988-10-04 |
KR960008653B1 (ko) | 1996-06-28 |
JPS63192724A (ja) | 1988-08-10 |
JP2547556B2 (ja) | 1996-10-23 |
DE3889938D1 (de) | 1994-07-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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