GB865594A - Improvements in or relating to producing crystalline lactulose - Google Patents

Improvements in or relating to producing crystalline lactulose

Info

Publication number
GB865594A
GB865594A GB19303/59A GB1930359A GB865594A GB 865594 A GB865594 A GB 865594A GB 19303/59 A GB19303/59 A GB 19303/59A GB 1930359 A GB1930359 A GB 1930359A GB 865594 A GB865594 A GB 865594A
Authority
GB
United Kingdom
Prior art keywords
lactose
lactulose
solution
concentrated
filtered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB19303/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TERVALON NV
Original Assignee
TERVALON NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TERVALON NV filed Critical TERVALON NV
Publication of GB865594A publication Critical patent/GB865594A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • A23C9/203—Dietetic milk products not covered by groups A23C9/12 - A23C9/18 containing bifidus-active substances, e.g. lactulose; containing oligosaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C13—SUGAR INDUSTRY
    • C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
    • C13K13/00—Sugars not otherwise provided for in this class
    • C13K13/005—Lactulose

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Production of a crystalline lactulose product of at least 80% lactulose content entails heating a solution of lactose of pH greater than 5 at a temperature between room temperature and 150 DEG C., separating the unconverted lactose, oxidizing the residue with bromine and separating the acids formed. According to an example, a lactose solution treated with calcium hydroxide is heated at 100-102 DEG C. for 15 min., and is allowed to cool; after 2 days, crystallized lactose is filtered off, the liquid is concentrated and further lactose is filtered off; the filtrate is diluted and sodium bromide is added; the resulting solution is electrolyzed, using graphite electrodes, until aldoses are no longer detectable chromatographically; during the bromine oxidation, calcium carbonate is added to neutralize the acids formed, and, after the oxidation, the product is passed over cation and anion exchangers, the solution obtained is concentrated in vacuo and is further dehydrated by treating with, and distilling off, methanol, the lactulose being finally allowed to crystallize out. Specification 761,866 also is referred to.
GB19303/59A 1956-03-10 1957-03-07 Improvements in or relating to producing crystalline lactulose Expired GB865594A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL865594X 1956-03-10

Publications (1)

Publication Number Publication Date
GB865594A true GB865594A (en) 1961-04-19

Family

ID=19849267

Family Applications (1)

Application Number Title Priority Date Filing Date
GB19303/59A Expired GB865594A (en) 1956-03-10 1957-03-07 Improvements in or relating to producing crystalline lactulose

Country Status (1)

Country Link
GB (1) GB865594A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2392031A1 (en) * 1977-05-26 1978-12-22 Morinaga Milk Industry Co Ltd PROCESS FOR PREPARING A POWDER CONTAINING NON-HYGROSCOPIC LACTULOSE
EP0132509A1 (en) * 1983-06-20 1985-02-13 Sirac Srl Process for purifying lactulose syrup
US4565582A (en) * 1984-03-22 1986-01-21 Sirac S.P.A. Lactulose purification process
US4978397A (en) * 1987-12-30 1990-12-18 Sirac Srl. Process for preparing high-purity lactulose syrup and the syrup obtained

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2392031A1 (en) * 1977-05-26 1978-12-22 Morinaga Milk Industry Co Ltd PROCESS FOR PREPARING A POWDER CONTAINING NON-HYGROSCOPIC LACTULOSE
EP0132509A1 (en) * 1983-06-20 1985-02-13 Sirac Srl Process for purifying lactulose syrup
US4565582A (en) * 1984-03-22 1986-01-21 Sirac S.P.A. Lactulose purification process
US4978397A (en) * 1987-12-30 1990-12-18 Sirac Srl. Process for preparing high-purity lactulose syrup and the syrup obtained

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