GB831904A - Process for the preparation of crystalline dihydrostreptomycin sulphate - Google Patents
Process for the preparation of crystalline dihydrostreptomycin sulphateInfo
- Publication number
- GB831904A GB831904A GB2704457A GB2704457A GB831904A GB 831904 A GB831904 A GB 831904A GB 2704457 A GB2704457 A GB 2704457A GB 2704457 A GB2704457 A GB 2704457A GB 831904 A GB831904 A GB 831904A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sulphate
- dihydrostreptomycin
- dihydrostreptomycin sulphate
- crystalline
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Crystalline dihydrostreptomycin sulphate is produced by adding at an elevated temperature a concentrated aqueous solution of dihydrostreptomycin sulphate to an aqueous solution of methanol containing, for example, 15 to 40% by volume of water and especially 30%. The aqueous solution of dihydrostreptomycin contains 150,000 to 500,000 and especially 300,000 units per ml. The temperature is 40 DEG to 70 DEG C. and the mixture is maintained at this temperature by heating the mixture or by adding heated aqueous dihydrostreptomycin sulphate. Preferably the aqueous methanol contains an amount of seed crystals of dihydrostreptomycin sulphate equal to about 1% of the expected total yield of crystalline dihydrostreptomycin sulphate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2704457A GB831904A (en) | 1957-08-28 | 1957-08-28 | Process for the preparation of crystalline dihydrostreptomycin sulphate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2704457A GB831904A (en) | 1957-08-28 | 1957-08-28 | Process for the preparation of crystalline dihydrostreptomycin sulphate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB831904A true GB831904A (en) | 1960-04-06 |
Family
ID=10253244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2704457A Expired GB831904A (en) | 1957-08-28 | 1957-08-28 | Process for the preparation of crystalline dihydrostreptomycin sulphate |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB831904A (en) |
-
1957
- 1957-08-28 GB GB2704457A patent/GB831904A/en not_active Expired
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