SU465814A1 - Phlorimycin producing method - Google Patents

Phlorimycin producing method

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Publication number
SU465814A1
SU465814A1 SU651001763A SU1001763A SU465814A1 SU 465814 A1 SU465814 A1 SU 465814A1 SU 651001763 A SU651001763 A SU 651001763A SU 1001763 A SU1001763 A SU 1001763A SU 465814 A1 SU465814 A1 SU 465814A1
Authority
SU
USSR - Soviet Union
Prior art keywords
solution
target product
culture fluid
phlorimycin
producing method
Prior art date
Application number
SU651001763A
Other languages
Russian (ru)
Inventor
С.А. Жуковская
Г.С. Либинсон
Original Assignee
Всесоюзный научно-исследовательский институт антибиотиков
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Всесоюзный научно-исследовательский институт антибиотиков filed Critical Всесоюзный научно-исследовательский институт антибиотиков
Priority to SU651001763A priority Critical patent/SU465814A1/en
Application granted granted Critical
Publication of SU465814A1 publication Critical patent/SU465814A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Description

60%-ным (60 мл), а затем чистым метанолом (30 мл). После высушивани  при комнатной температуре иод вакуумом в течение 20 ч и при 50°С в течение 3 ч иолучают 39 г антибиотика, что составл ет 55% от содержани  его в культуральной жидкости.60% (60 ml), and then pure methanol (30 ml). After drying at room temperature with vacuum for 20 hours and at 50 ° C for 3 hours, 39 g of antibiotic are obtained, which is 55% of its content in the culture fluid.

Claims (1)

Формула изобретени Invention Formula Способ иолучени  флоримицина путем ионообменной сорбции нативного раствора, элюции антибиотика раствором серной кислоты с последующей его кристаллизациейThe method of obtaining florimycin by ion-exchange sorption of a native solution, eluting the antibiotic with a solution of sulfuric acid, followed by crystallization из метанола, отличающийс  тем, что, с целью повыщени  качества и выхода целевого продукта, культуральную жидкость обрабатывают поочередно растворами ортофосфорной кислоты и едкого натра (рН около 7-8), добавл ют хлористый кальций в количестве 0,5% к объему культуральной жидкости, нативный раствор пропускают через катионит, например КБ-2ХЗ, элюат профильтровывают через сульфокатионит , например КУ-2Х20, и анионит, например ЭДЭ-10, далее целевой продукт выдел ют известными приемами.from methanol, characterized in that, in order to increase the quality and yield of the target product, the culture fluid is alternately treated with solutions of orthophosphoric acid and caustic soda (pH about 7-8), calcium chloride is added in an amount of 0.5% by volume of the culture fluid, the native solution is passed through a cation exchanger, for example KB-2KhZ, the eluate is filtered through sulfonic cation exchanger, for example KU-2X20, and an anion exchanger, for example EDE-10, then the target product is isolated by known methods.
SU651001763A 1965-04-06 1965-04-06 Phlorimycin producing method SU465814A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU651001763A SU465814A1 (en) 1965-04-06 1965-04-06 Phlorimycin producing method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU651001763A SU465814A1 (en) 1965-04-06 1965-04-06 Phlorimycin producing method

Publications (1)

Publication Number Publication Date
SU465814A1 true SU465814A1 (en) 1979-09-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SU651001763A SU465814A1 (en) 1965-04-06 1965-04-06 Phlorimycin producing method

Country Status (1)

Country Link
SU (1) SU465814A1 (en)

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