KR850006130A - 서방성 조성물 및 그의 제조방법 - Google Patents

서방성 조성물 및 그의 제조방법 Download PDF

Info

Publication number
KR850006130A
KR850006130A KR1019850001636A KR850001636A KR850006130A KR 850006130 A KR850006130 A KR 850006130A KR 1019850001636 A KR1019850001636 A KR 1019850001636A KR 850001636 A KR850001636 A KR 850001636A KR 850006130 A KR850006130 A KR 850006130A
Authority
KR
South Korea
Prior art keywords
sustained release
release composition
preparation
isobutyryl
pyridine
Prior art date
Application number
KR1019850001636A
Other languages
English (en)
Inventor
쯔또무(외 3) 이리꾸라
Original Assignee
오기하라슈
교오린세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오기하라슈, 교오린세이야꾸 가부시끼가이샤 filed Critical 오기하라슈
Publication of KR850006130A publication Critical patent/KR850006130A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

서방성 조성물 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명에서 제조된 서방성 과립의 용출률을 나타낸 도표임.
제2도는 각종 과립 혼합 조성물의 용출 시험 결과를 나타낸 도표임.
제3도는 Ⅵ(KC-404의 10mg)의 경우를 제외하고 KC-404의 20mg에 상당하는 본 발명에서 제조된 조성물 또는 분말을 투여한 건강인의 혈중 농도를 나타낸 도표임.

Claims (3)

  1. 3-이소부티릴-2-이소프로필 피라졸로〔1,5-a〕피리딘을 과립으로 만든 다음 그 결과 형성된 입자를 의학적으로 비활성인 물질로 피복하는 것으로 구성된 서방성 조성물의 제조방법.
  2. 3-이소부티릴-2-이소프로필 피라졸로〔1,5-a〕피리딘을 지방물질에 매립하는 것을 특징으로 하는 서방성 조성물의 제조방법.
  3. 3-이소부치릴-2-이소프로필 피라졸로〔1,5-a〕피리딘을 직장용 좌제에 매립시키는 것을 특징으로 하는 서방성 조성물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850001636A 1984-03-14 1985-03-14 서방성 조성물 및 그의 제조방법 KR850006130A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59048441A JPH0621066B2 (ja) 1984-03-14 1984-03-14 ３―イソブチリル―２―イソプロピルピラゾロ〔１，５―ａ〕ピリジンの徐放性医薬品組成物
JP48441 1984-03-14

Publications (1)

Publication Number Publication Date
KR850006130A true KR850006130A (ko) 1985-10-02

Family

ID=12803438

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850001636A KR850006130A (ko) 1984-03-14 1985-03-14 서방성 조성물 및 그의 제조방법

Country Status (11)

Country Link
US (1) US5151434A (ko)
EP (2) EP0375662A3 (ko)
JP (1) JPH0621066B2 (ko)
KR (1) KR850006130A (ko)
AU (1) AU582739B2 (ko)
DE (2) DE156243T1 (ko)
DK (2) DK169421B1 (ko)
IE (1) IE57853B1 (ko)
NZ (1) NZ211424A (ko)
PH (1) PH21996A (ko)
ZA (1) ZA851830B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6263520A (ja) * 1985-09-14 1987-03-20 Kyorin Pharmaceut Co Ltd 抗リウマチ剤
JPH01153633A (ja) * 1987-12-10 1989-06-15 Kyorin Pharmaceut Co Ltd 経皮吸収製剤
JPH01153634A (ja) * 1987-12-10 1989-06-15 Kyorin Pharmaceut Co Ltd 吸入剤
US5213800A (en) * 1989-02-09 1993-05-25 Diamond Scientific Company Chlorhexidine disinfectant granules
JPH0674206B2 (ja) * 1989-12-28 1994-09-21 田辺製薬株式会社 放出制御型製剤およびその製法
JP2558396B2 (ja) * 1990-06-28 1996-11-27 田辺製薬株式会社 放出制御型製剤
US6548084B2 (en) * 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
US8293277B2 (en) 1998-10-01 2012-10-23 Alkermes Pharma Ireland Limited Controlled-release nanoparticulate compositions
EP1117384A1 (en) * 1998-10-01 2001-07-25 Elan Pharma International Limited Controlled release nanoparticulate compositions
US7198795B2 (en) 2000-09-21 2007-04-03 Elan Pharma International Ltd. In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions
US6720356B2 (en) * 2001-04-20 2004-04-13 Spencer Feldman Magnesium di-potassium EDTA complex and method of administration
ATE464880T1 (de) 2002-02-04 2010-05-15 Elan Pharma Int Ltd Arzneistoffnanopartikel mit lysozym- oberflächenstabilisator
FR2891459B1 (fr) * 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
CA2654498A1 (en) * 2006-06-06 2007-12-21 Avigen, Inc. Substituted pyrazolo[1,5-.alpha.]pyridine compounds and their methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784683A (en) * 1971-03-29 1974-01-08 Abbott Lab Tablet preparation
JPS5229318B2 (ko) * 1972-03-30 1977-08-01
JPS5229318A (en) * 1975-09-01 1977-03-05 Nippon Telegraph & Telephone Type head for high speed printer or the like
CA1188505A (en) * 1982-08-24 1985-06-11 Kenneth L. Hurley Toner feeder system
US4540566A (en) * 1984-04-02 1985-09-10 Forest Laboratories, Inc. Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose
JPS6263520A (ja) * 1985-09-14 1987-03-20 Kyorin Pharmaceut Co Ltd 抗リウマチ剤

Also Published As

Publication number Publication date
DE3580774D1 (de) 1991-01-17
EP0156243A2 (en) 1985-10-02
DK57993A (da) 1993-05-18
EP0156243B1 (en) 1990-12-05
JPS60193913A (ja) 1985-10-02
EP0375662A2 (en) 1990-06-27
DE156243T1 (de) 1986-05-22
DK106685D0 (da) 1985-03-08
DK106685A (da) 1985-09-15
DK57993D0 (da) 1993-05-18
DK169096B1 (da) 1994-08-15
ZA851830B (en) 1985-11-27
IE57853B1 (en) 1993-04-21
AU3967685A (en) 1985-09-19
DK169421B1 (da) 1994-10-31
NZ211424A (en) 1988-09-29
AU582739B2 (en) 1989-04-13
PH21996A (en) 1988-05-02
JPH0621066B2 (ja) 1994-03-23
EP0375662A3 (en) 1990-11-07
IE850593L (en) 1985-09-14
EP0156243A3 (en) 1987-03-25
US5151434A (en) 1992-09-29

Similar Documents

Publication Publication Date Title
KR850006130A (ko) 서방성 조성물 및 그의 제조방법
ATE24838T1 (de) Lyophilisierte zusammensetzungen, ihre herstellung und verwendung.
IE781716L (en) Trihydroxypiperidine compounds
IL86170A0 (en) Preparations containing nicotine
JPS57190646A (en) Production of sub-micron particle, obtained particle and drug composition containing same
PL314187A1 (en) Novel derivatives of pyrazine carboxamide, method of obtaining them and their application in pharmaceutical composition
ES481155A1 (es) Procedimiento para la obtencion de imidazo-(2,1-b)-(1,3,4)- tiadiazoles.
NO174062C (no) Fremgangsmåte for fremstilling av blekende granulat, samt anvendelse av granulatet
ES8703472A1 (es) Procedimiento para preparar nuevos derivados imidazo
HUT55773A (en) Composition against endoparasites containing 3-hydroxy-benzo-thiophene- or 3-hydroxy-thienopyridine derivatives as active components and process for producing some of the active components
ATE13898T1 (de) Chemische blaehmittelzusammensetzung, ihre herstellung und anwendung.
DE3676997D1 (de) Theophyllintabletten mit verzoegerter freigabe.
PH12274A (en) 6-chloro 2(1'-piperazinyl)pyrazine compound,pharmaceutical composition and method of use thereof
GEP19981357B (en) New Adenozine Derivatives, Prepatation Methods and Pharmaceutical Composit¬i¬ons Containing Them
PT87699A (pt) Process for the preparation of tricyclic pyridone derivatives and of pharmaceutical compositions containing the same
JPS5770875A (en) Novel derivatives of 4h-1,2,4-triazole, manufacture, use as drug, composition containing them and intermediate product
JPS5610166A (en) Novel derivatives of alphaaphenyll22 purrolidineemethanol and salts thereof* these manufacture* application as drug and composition containing them
ES455133A1 (es) Un procedimiento de preparacion de 17-esteres de 17-alfa-hi-droxi-gestogenos.
ES8705439A1 (es) Procedimiento para preparar derivados de pirazol-(1,5-a)piridina
JPS56123912A (en) Drug-containing tape preparation
JPS52105220A (en) Composition for rectal administration comprising beta-lactam ring containing substance and method of making same
NO903650D0 (no) Blekeaktivator i form av granulerte partikler.
PT71211A (en) Process for the preparation of 3-substituted-tetrahydropyrrolo/1,2-a/pyrimidines and pharmaceutical compositions containing the same and new 3-substituted-tetrahydro-pyrrolo/1,2-a/ pyrimidines
JPS537638A (en) Production of novel 1*33 diphenoxy propanoll*2** derivatives and pharmaceutical composition containing same
JPS5238984A (en) Clay composition for handicrafts

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E902 Notification of reason for refusal
E601 Decision to refuse application