ES481155A1 - Procedimiento para la obtencion de imidazo-(2,1-b)-(1,3,4)- tiadiazoles. - Google Patents

Procedimiento para la obtencion de imidazo-(2,1-b)-(1,3,4)- tiadiazoles.

Info

Publication number
ES481155A1
ES481155A1 ES481155A ES481155A ES481155A1 ES 481155 A1 ES481155 A1 ES 481155A1 ES 481155 A ES481155 A ES 481155A ES 481155 A ES481155 A ES 481155A ES 481155 A1 ES481155 A1 ES 481155A1
Authority
ES
Spain
Prior art keywords
imidazo
thiadiazoles
medicaments
preparation
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES481155A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES481155A1 publication Critical patent/ES481155A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Lubricants (AREA)
  • Detergent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procedimiento para la obtención de imidazo-[2,1-b]-[1,3,4]-tiadiazoles de fórmula general (I) **(Fórmula)** donde R1 significa un resto arilo, que en caso dado contiene 1 ó 2 sustituyentes iguales o diferente del grupo halógeno, trifluormetilo, alquilo, alquenilo, fenilo, alcoxi, nitro, ciano, sulfonamido o Son-alquilo (n=0, 1 ó 2), R2 significa hidrógeno, alquilo, alquinilo o un resto arilo, en caso dado sustituido por halógeno, alquilo, alquenilo o alcoxi, y R3 significa un resto naftilo, furilo, tienilo o piridilo, que en caso dado está sustituido por 1 ó 2 restos alquilo.
ES481155A 1978-05-31 1979-05-31 Procedimiento para la obtencion de imidazo-(2,1-b)-(1,3,4)- tiadiazoles. Expired ES481155A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782823686 DE2823686A1 (de) 1978-05-31 1978-05-31 Imidazo eckige klammer auf 2.1-b eckige klammer zu eckige klammer auf 1.3.4 eckige klammer zu -thiadiazole

Publications (1)

Publication Number Publication Date
ES481155A1 true ES481155A1 (es) 1979-11-16

Family

ID=6040588

Family Applications (1)

Application Number Title Priority Date Filing Date
ES481155A Expired ES481155A1 (es) 1978-05-31 1979-05-31 Procedimiento para la obtencion de imidazo-(2,1-b)-(1,3,4)- tiadiazoles.

Country Status (12)

Country Link
US (1) US4265898A (es)
EP (1) EP0005783B1 (es)
JP (1) JPS54157564A (es)
AT (1) ATE512T1 (es)
AU (1) AU523229B2 (es)
CA (1) CA1128941A (es)
DE (2) DE2823686A1 (es)
DK (1) DK225579A (es)
ES (1) ES481155A1 (es)
FI (1) FI66390C (es)
HU (1) HU179411B (es)
IL (1) IL57420A (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO811630L (no) * 1980-05-29 1981-11-30 Bayer Ag Imidazoazolalkensyreamider, nye mellomprodukter for deres fremstilling, deres fremstilling og deres anvendelse som legemiddel
IT8148047A0 (it) * 1981-03-18 1981-03-18 Manetti & Roberts Italo Brit Composti organici derivati da 2-ami no-5-(o-solfamidofenil)-1,3,4-tiadiazolo loro applicazione terapeutica e procedimento per la loro preparazione
DE3208437A1 (de) * 1982-03-09 1983-09-15 Bayer Ag, 5090 Leverkusen Imidazothiadiazolalkencarbonsaeureamide, neue zwischenprodukte zu ihrer herstellung, ihre herstellung und ihre verwendung in arzneimitteln
US4968494A (en) * 1987-03-27 1990-11-06 Merck & Co., Inc. Methods and compositions for thrombolytic therapy
US4968713A (en) * 1989-07-31 1990-11-06 Merck & Co., Inc. Certain imidazole compounds as transglutaminase inhibitors
US5077285A (en) * 1989-07-31 1991-12-31 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5019572A (en) * 1990-02-07 1991-05-28 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5021440A (en) * 1989-07-31 1991-06-04 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5030644A (en) * 1989-07-31 1991-07-09 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5047416A (en) * 1989-07-31 1991-09-10 Merck & Co., Inc. Triazole compounds and their use as transglutaminase inhibitors
US8173661B2 (en) 2006-11-08 2012-05-08 The Rockefeller University Alpha-IIB-beta-3 inhibitors and uses thereof
WO2012009688A1 (en) 2010-07-16 2012-01-19 Rockefeller University Organic compounds
EP2804610B1 (en) 2012-01-16 2018-10-31 The Rockefeller University Organic compounds
HUE060743T2 (hu) * 2012-04-26 2023-04-28 Bristol Myers Squibb Co Gyógyszerészeti kompozíciók, amelyek tartalmaznak imidazothiadiazol- és imidazopiridazinszármazékokat mint proteáz aktívált receptor 4 (PAR4) inhibitorokat trombocitaaggregációk kezelésére
JP6101343B2 (ja) * 2012-04-26 2017-03-22 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 血小板凝集を治療するためのプロテアーゼ活性化受容体４（ｐａｒ４）阻害剤としてのイミダゾチアジアゾールおよびイミダゾピリダジン誘導体
CN104540835B (zh) * 2012-04-26 2017-08-08 百时美施贵宝公司 用于治疗血小板聚集的作为蛋白酶激活受体4(par4)抑制剂的咪唑并噻二唑衍生物
EP2682395A1 (en) * 2012-07-04 2014-01-08 Laboratorios Del. Dr. Esteve, S.A. Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments
US9617279B1 (en) 2014-06-24 2017-04-11 Bristol-Myers Squibb Company Imidazooxadiazole compounds
US9598419B1 (en) 2014-06-24 2017-03-21 Universite De Montreal Imidazotriazine and imidazodiazine compounds
US20190119300A1 (en) * 2016-04-18 2019-04-25 Vanderbilt University Substituted and fused 6-membered protease activated receptor 4 (par-4) antagonists
WO2019218956A1 (zh) * 2018-05-16 2019-11-21 深圳信立泰药业股份有限公司 作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的化合物
CN112074522B (zh) * 2018-05-16 2022-08-26 深圳信立泰药业股份有限公司 作为用于治疗血小板聚集的蛋白酶激活受体4(par4)抑制剂的化合物
AU2019288262B2 (en) 2018-06-19 2024-06-06 Celecor Therapeutics, Inc. Deuterated RUC-4
WO2023093700A1 (zh) * 2021-11-29 2023-06-01 中国海洋大学 咪唑并噻唑衍生物及其制备方法与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3726891A (en) * 1970-12-02 1973-04-10 Shell Oil Co Fused 1,2,4-thiadiazolines
US3804823A (en) * 1972-02-15 1974-04-16 Eastman Kodak Co Heterocyclic containing monoazo compounds
GB1464259A (en) * 1975-10-03 1977-02-09 Pfizer Ltd Imidazo-thiazole and -thiadiazole sulphonamides and their use as therapeutic agents
US4042372A (en) * 1976-11-19 1977-08-16 Eli Lilly And Company Substituted thiadiazolotriazinediones and method of preparation

Also Published As

Publication number Publication date
FI791708A (fi) 1979-12-01
AU4760679A (en) 1979-12-06
EP0005783B1 (de) 1981-12-30
AU523229B2 (en) 1982-07-15
EP0005783A1 (de) 1979-12-12
DE2823686A1 (de) 1979-12-06
FI66390C (fi) 1984-10-10
DE2961667D1 (en) 1982-02-18
JPS54157564A (en) 1979-12-12
IL57420A0 (en) 1979-09-30
IL57420A (en) 1983-06-15
US4265898A (en) 1981-05-05
ATE512T1 (de) 1982-01-15
HU179411B (en) 1982-10-28
FI66390B (fi) 1984-06-29
CA1128941A (en) 1982-08-03
DK225579A (da) 1979-12-01

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