ES8703472A1 - Procedimiento para preparar nuevos derivados imidazo - Google Patents

Procedimiento para preparar nuevos derivados imidazo

Info

Publication number
ES8703472A1
ES8703472A1 ES550241A ES550241A ES8703472A1 ES 8703472 A1 ES8703472 A1 ES 8703472A1 ES 550241 A ES550241 A ES 550241A ES 550241 A ES550241 A ES 550241A ES 8703472 A1 ES8703472 A1 ES 8703472A1
Authority
ES
Spain
Prior art keywords
preparation
medicines containing
imidazo derivatives
derivatives
imidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550241A
Other languages
English (en)
Other versions
ES550241A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES550241A0 publication Critical patent/ES550241A0/es
Publication of ES8703472A1 publication Critical patent/ES8703472A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS IMIDAZO. CONSISTENTE EN: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON OTRO COMPUESTO DE FORMULA (III) EN UN MEDIO DISOLVENTE COMO ETANOL, ISOPROPANOL, BENCENO U OTROS, A UNA TEMPERATURA ENTRE 20 Y 100JC, AUNQUE EL DISOLVENTE PUEDE SER OPCIONAL, PARA DAR UN COMPUESTO DE FORMULA (I); B) SI EL COMPUESTO DE FORMULA (I) OBTENIDO TIENE UNO DE SUS RADICALES A, B, C O D CON UN ATOMO DE HALOGENO SUSTITUYENDO A UN METILO, ESTE SE TRANSFORMA POR AMINOLISIS EN EL SIGUIENTE COMPUESTO AMINICO; Y C) TRANSFORMAR EL COMPUESTO DE FORMULA (I) EN SU SAL CORRESPONDIENTE POR ADICION DE UN ACIDO COMO CLH, BROMHIDRICO U OTROS. SIENDO: A, B, C, D, RADICALES DONDE UNO O DOS ES NITROGENO, OTRO ES UN GRUPO METILO SUSTITUIDO CON UN HALOGENO, ALQUILMERCAPTO U OTROS, Y OTRO ES UN GRUPO METILO EVENTUALMENTE SUSTITUIDO POR MERCAPTO; R1 Y R2, ANILLO FENILO; R3, UN ATOMO DE HIDROGENO U OTROS; Y X, UN GRUPO LABIL NUCLEOFILO. APLICACION FARMACOLOGICA.
ES550241A 1984-12-21 1985-12-20 Procedimiento para preparar nuevos derivados imidazo Expired ES8703472A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843446778 DE3446778A1 (de) 1984-12-21 1984-12-21 Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES550241A0 ES550241A0 (es) 1987-02-16
ES8703472A1 true ES8703472A1 (es) 1987-02-16

Family

ID=6253488

Family Applications (2)

Application Number Title Priority Date Filing Date
ES550241A Expired ES8703472A1 (es) 1984-12-21 1985-12-20 Procedimiento para preparar nuevos derivados imidazo
ES556974A Expired ES8801276A1 (es) 1984-12-21 1986-07-23 Procedimiento para preparar nuevos derivados imidazo

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES556974A Expired ES8801276A1 (es) 1984-12-21 1986-07-23 Procedimiento para preparar nuevos derivados imidazo

Country Status (14)

Country Link
US (1) US4716169A (es)
EP (1) EP0185345A1 (es)
JP (1) JPS61152681A (es)
AU (1) AU5154585A (es)
DD (1) DD242407A5 (es)
DE (1) DE3446778A1 (es)
DK (1) DK590185A (es)
ES (2) ES8703472A1 (es)
FI (1) FI855080A (es)
GR (1) GR853124B (es)
HU (1) HU194562B (es)
NO (1) NO855196L (es)
PT (1) PT81716B (es)
ZA (1) ZA859729B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4833149A (en) * 1986-09-22 1989-05-23 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
SE8704248D0 (sv) * 1987-10-30 1987-10-30 Haessle Ab Medical use
US5244908A (en) * 1990-07-30 1993-09-14 Takeda Chemical Industries, Ltd. Imidazopyridine derivatives and their pharmaceutical use
US6127576A (en) * 1996-12-20 2000-10-03 American Cyanamid Company Aminophenyl ketone derivatives and a method for the preparation thereof
JP4327915B2 (ja) * 1998-03-30 2009-09-09 株式会社デ・ウエスタン・セラピテクス研究所 スルフォンアミド誘導体
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
WO2007033080A2 (en) * 2005-09-12 2007-03-22 Emory University Alzheimer's disease imaging agents
US7723336B2 (en) * 2005-09-22 2010-05-25 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
EP2808020A1 (en) * 2006-04-21 2014-12-03 The Government Of The United States, As Represented by The Secretary Of Health And Human Services Beta-Amyloid Pet Imaging Agents
EP1964840A1 (en) * 2007-02-28 2008-09-03 sanofi-aventis Imidazo[1,2-a]pyridines and their use as pharmaceuticals
EP1964841A1 (en) * 2007-02-28 2008-09-03 sanofi-aventis Imidazo[1,2-a]azine and their use as pharmaceuticals
US7868001B2 (en) 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
JP5394404B2 (ja) * 2008-02-06 2014-01-22 ブリストル−マイヤーズ スクイブ カンパニー キナーゼ阻害剤として有用な置換イミダゾピリダジン類
PT2280706E (pt) * 2008-05-14 2013-02-19 Otsuka Pharma Co Ltd Composições compreendendo derivados de benzeno que activam lipase de lipoproteína
SG11201406733QA (en) 2012-04-26 2014-11-27 Bristol Myers Squibb Co Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation
JP6181744B2 (ja) 2012-04-26 2017-08-16 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 血小板凝集を治療するためのプロテアーゼ活性化受容体４（ｐａｒ４）阻害剤としてのイミダゾチアジアゾール誘導体
CN104583218B (zh) * 2012-04-26 2018-04-24 百时美施贵宝公司 作为蛋白酶活化受体4(par4)抑制剂用于治疗血小板聚集的咪唑并噻二唑和咪唑并吡嗪的衍生物
US9598419B1 (en) 2014-06-24 2017-03-21 Universite De Montreal Imidazotriazine and imidazodiazine compounds
US9617279B1 (en) 2014-06-24 2017-04-11 Bristol-Myers Squibb Company Imidazooxadiazole compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS523957B2 (es) * 1974-03-14 1977-01-31
US4166851A (en) * 1977-05-16 1979-09-04 Merck & Co., Inc. Certain imidazo(1,2a)pyridine derivatives
ZA839398B (en) * 1982-12-27 1985-08-28 Lilly Co Eli Substituted imidazopyrimidines-pyrazines,and-triazines

Also Published As

Publication number Publication date
ES8801276A1 (es) 1988-01-01
ZA859729B (en) 1987-08-26
EP0185345A1 (de) 1986-06-25
DK590185A (da) 1986-06-22
HU194562B (en) 1988-02-29
GR853124B (es) 1986-04-22
NO855196L (no) 1986-06-23
US4716169A (en) 1987-12-29
JPS61152681A (ja) 1986-07-11
ES556974A0 (es) 1988-01-01
ES550241A0 (es) 1987-02-16
HUT40434A (en) 1986-12-28
AU5154585A (en) 1986-06-26
DE3446778A1 (de) 1986-07-03
PT81716A (de) 1986-01-01
DD242407A5 (de) 1987-01-28
FI855080A0 (fi) 1985-12-19
FI855080A (fi) 1986-06-22
PT81716B (de) 1987-10-15
DK590185D0 (da) 1985-12-18

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