DE156243T1 - Mittel mit gesteuerter freisetzung sowie dessen herstellung. - Google Patents
Mittel mit gesteuerter freisetzung sowie dessen herstellung.Info
- Publication number
- DE156243T1 DE156243T1 DE198585102826T DE85102826T DE156243T1 DE 156243 T1 DE156243 T1 DE 156243T1 DE 198585102826 T DE198585102826 T DE 198585102826T DE 85102826 T DE85102826 T DE 85102826T DE 156243 T1 DE156243 T1 DE 156243T1
- Authority
- DE
- Germany
- Prior art keywords
- isopropylpyrazolo
- isobutyryl
- preparation
- pyridine
- controlled release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (7)
1. Arzneimittel mit gesteuerter Wirkstoffabgabe von 3-Isobutyryl^-isopropylpyrazolo/f^-a/pyridin.
2. Arzneimittel nach Anspruch 1, in dem die Zubereitung mit gesteuerter Wirkstoffabgabe in Form eines Pulvers oder
Granulates vorliegt, das 3-Isobutyryl-2-isopropylpyrazolo/'T^-a/pyridin
enthält, beschichtet mit einem medizinisch nicht wirksamen Stoff.
3. Arzneimittel nach Anspruch 1, in dem 3-Isobutyryl-2-isopropylpyrazolo^T^-aZpyridin
in Fettstoffe implantiert ist.
4. Arzneimittel nach Anspruch 1, in dem die Zubereitung
mit gesteuerter Wirkstoffabgabe in Form eines 3-Isobutyryl-2-isopropylpyrazolo^T,5-a7pyridin
enthaltenden rektal zu gebenden Suppositoriums vorliegt.
5. Verfahren zur Herstellung einer Zubereitung mit gesteuerter Wirkstoffabgabe nach Anspruch 1, umfassend
die Granulierung von 3-Isobutyryl-2-isopropylpyrazolo-/T,5-a7pyridin
und Beschichtung der erhaltenen Teilchen mit einem medizinisch nicht wirksamen Stoff.
L J
1
6. Verfahren zur Herstellung des Präparates mit gesteuerter Wirkstoffabgabe nach Anspruch 1, umfäsend die Implantierung
von 3-Isobutyryl-2-isopropylpyrazolo^,5-a7-pyridin in Fettstoffe.
5
7. Verfahren zur Herstellung des Präparates mit gesteuerter Wirkstoffabgabe nach Anspruch 1, umfassend die Implantierung
von 3-Isobutyryl-2-isopropylpyrazolo/T,5-§7-pyridin in ein rektal zu verabreichendes Suppositorium.
10
L J
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59048441A JPH0621066B2 (ja) | 1984-03-14 | 1984-03-14 | 3―イソブチリル―2―イソプロピルピラゾロ〔1,5―a〕ピリジンの徐放性医薬品組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE156243T1 true DE156243T1 (de) | 1986-05-22 |
Family
ID=12803438
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8585102826T Expired - Lifetime DE3580774D1 (de) | 1984-03-14 | 1985-03-12 | Mittel mit gesteuerter freisetzung sowie dessen herstellung. |
DE198585102826T Pending DE156243T1 (de) | 1984-03-14 | 1985-03-12 | Mittel mit gesteuerter freisetzung sowie dessen herstellung. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8585102826T Expired - Lifetime DE3580774D1 (de) | 1984-03-14 | 1985-03-12 | Mittel mit gesteuerter freisetzung sowie dessen herstellung. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5151434A (de) |
EP (2) | EP0156243B1 (de) |
JP (1) | JPH0621066B2 (de) |
KR (1) | KR850006130A (de) |
AU (1) | AU582739B2 (de) |
DE (2) | DE3580774D1 (de) |
DK (2) | DK169421B1 (de) |
IE (1) | IE57853B1 (de) |
NZ (1) | NZ211424A (de) |
PH (1) | PH21996A (de) |
ZA (1) | ZA851830B (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6263520A (ja) * | 1985-09-14 | 1987-03-20 | Kyorin Pharmaceut Co Ltd | 抗リウマチ剤 |
JPH01153633A (ja) | 1987-12-10 | 1989-06-15 | Kyorin Pharmaceut Co Ltd | 経皮吸収製剤 |
JPH01153634A (ja) * | 1987-12-10 | 1989-06-15 | Kyorin Pharmaceut Co Ltd | 吸入剤 |
US5213800A (en) * | 1989-02-09 | 1993-05-25 | Diamond Scientific Company | Chlorhexidine disinfectant granules |
JPH0674206B2 (ja) * | 1989-12-28 | 1994-09-21 | 田辺製薬株式会社 | 放出制御型製剤およびその製法 |
JP2558396B2 (ja) * | 1990-06-28 | 1996-11-27 | 田辺製薬株式会社 | 放出制御型製剤 |
US6548084B2 (en) * | 1995-07-20 | 2003-04-15 | Smithkline Beecham Plc | Controlled release compositions |
US8293277B2 (en) | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
WO2000018374A1 (en) * | 1998-10-01 | 2000-04-06 | Elan Pharma International, Ltd. | Controlled release nanoparticulate compositions |
US8236352B2 (en) | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
US7198795B2 (en) | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
US6720356B2 (en) * | 2001-04-20 | 2004-04-13 | Spencer Feldman | Magnesium di-potassium EDTA complex and method of administration |
JP4598399B2 (ja) | 2002-02-04 | 2010-12-15 | エラン ファーマ インターナショナル,リミティド | 表面安定剤としてリゾチームを有するナノ粒子組成物 |
FR2891459B1 (fr) * | 2005-09-30 | 2007-12-28 | Flamel Technologies Sa | Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant |
JP5352452B2 (ja) * | 2006-06-06 | 2013-11-27 | メディシノバ, インコーポレイテッド | 置換ピラゾロ[1,5−a]ピリジン化合物およびその使用方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3784683A (en) * | 1971-03-29 | 1974-01-08 | Abbott Lab | Tablet preparation |
JPS5229318B2 (de) * | 1972-03-30 | 1977-08-01 | ||
JPS5229318A (en) * | 1975-09-01 | 1977-03-05 | Nippon Telegraph & Telephone | Type head for high speed printer or the like |
CA1188505A (en) * | 1982-08-24 | 1985-06-11 | Kenneth L. Hurley | Toner feeder system |
US4540566A (en) * | 1984-04-02 | 1985-09-10 | Forest Laboratories, Inc. | Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose |
JPS6263520A (ja) * | 1985-09-14 | 1987-03-20 | Kyorin Pharmaceut Co Ltd | 抗リウマチ剤 |
-
1984
- 1984-03-14 JP JP59048441A patent/JPH0621066B2/ja not_active Expired - Lifetime
-
1985
- 1985-03-07 IE IE593/85A patent/IE57853B1/en not_active IP Right Cessation
- 1985-03-08 AU AU39676/85A patent/AU582739B2/en not_active Expired
- 1985-03-08 DK DK106685A patent/DK169421B1/da not_active IP Right Cessation
- 1985-03-11 PH PH31970A patent/PH21996A/en unknown
- 1985-03-12 EP EP85102826A patent/EP0156243B1/de not_active Expired - Lifetime
- 1985-03-12 DE DE8585102826T patent/DE3580774D1/de not_active Expired - Lifetime
- 1985-03-12 EP EP19900102574 patent/EP0375662A3/de not_active Withdrawn
- 1985-03-12 DE DE198585102826T patent/DE156243T1/de active Pending
- 1985-03-12 ZA ZA851830A patent/ZA851830B/xx unknown
- 1985-03-13 NZ NZ211424A patent/NZ211424A/xx unknown
- 1985-03-14 KR KR1019850001636A patent/KR850006130A/ko not_active Application Discontinuation
-
1989
- 1989-12-12 US US07/448,889 patent/US5151434A/en not_active Expired - Lifetime
-
1993
- 1993-05-18 DK DK057993A patent/DK169096B1/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU582739B2 (en) | 1989-04-13 |
EP0156243B1 (de) | 1990-12-05 |
EP0156243A2 (de) | 1985-10-02 |
DK57993A (da) | 1993-05-18 |
EP0156243A3 (en) | 1987-03-25 |
KR850006130A (ko) | 1985-10-02 |
JPH0621066B2 (ja) | 1994-03-23 |
DK169421B1 (da) | 1994-10-31 |
DK169096B1 (da) | 1994-08-15 |
EP0375662A2 (de) | 1990-06-27 |
US5151434A (en) | 1992-09-29 |
IE850593L (en) | 1985-09-14 |
DK106685A (da) | 1985-09-15 |
PH21996A (en) | 1988-05-02 |
ZA851830B (en) | 1985-11-27 |
DK106685D0 (da) | 1985-03-08 |
NZ211424A (en) | 1988-09-29 |
DE3580774D1 (de) | 1991-01-17 |
DK57993D0 (da) | 1993-05-18 |
EP0375662A3 (de) | 1990-11-07 |
IE57853B1 (en) | 1993-04-21 |
AU3967685A (en) | 1985-09-19 |
JPS60193913A (ja) | 1985-10-02 |
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