KR850001157A - 3-치환-3-아미노니트릴의 제조방법 - Google Patents

3-치환-3-아미노니트릴의 제조방법 Download PDF

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KR850001157A
KR850001157A KR1019840003388A KR840003388A KR850001157A KR 850001157 A KR850001157 A KR 850001157A KR 1019840003388 A KR1019840003388 A KR 1019840003388A KR 840003388 A KR840003388 A KR 840003388A KR 850001157 A KR850001157 A KR 850001157A
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cycloalkyl
alkyl
ammonia
equivalent
solvent
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KR1019840003388A
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KR870001538B1 (ko
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어빈 해클러 로날드 (외 1)
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아더 아르. 훼일
일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/18—Preparation of carboxylic acid nitriles by reaction of ammonia or amines with compounds containing carbon-to-carbon multiple bonds other than in six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음

Description

3-치환-3-아미노니트릴의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 구조식 II의 케토니트릴을 암모니아소스와 반응시켜서 구조식 III의 아미노니트릴을 제조하는 신규방법.
    상기식에서, R은 C1-C10알킬, C3-C6사이클로알킬, (C1-C4알킬) C3-C6사이클로알킬, (C2-C4알케닐) C3-C6사이클로알킬, (C1-C4할로알킬) C3-C6사이클로알킬, (C3-C6사이클로알킬) C1-C4알킬, 2-티에닐, 또는
    여기에서 R2는 수소, 할로, C1-C6알킬, C1-C3알콕시 또는 트리플루오로메틸; n은 1 또는 2이며; m은 또는 1이다.
  2. 제1항에서 구조식 III의 화합물이 구조식 IIIA의 화합물의 서브크라스로 표시되는 방법.
    상기식에서,
    R3는 C4-C10알킬(단 R3는 1-에틸프로필은 될 수 없다); C3-C6사이클로알킬; (C1｜C4알킬) C3-C6사이클로알킬; (C2-C4알케닐) C3-C6사이클로알킬; (C1-C4할로알킬) C3-C6사이클로알킬; 또는 (C3-C6사이클로알킬) C1-C4알킬이다.
  3. 제1 또는 2항에서, 암모니아소스가(1) 밀폐된 용기중, 약 100-약 150℃의 온도에서 적어도 1당량의 암모니아이거나, 또는 (2) 불활성용기 용매중에서 암모니움 설페이트가 아닌 암모니움염의 존재하에 약 25-약 80℃의 온도에서 적어도 1당량의 암모니아인 방법.
  4. 제3항에서, 케토니트릴을 밀폐된 용기에서 약 100-약 150℃의 온도에서 적어도 1당량의 암모니아로 처리하는 방법.
  5. 제4항에서, 불활성 극성용매를 사용하는 방법.
  6. 제5항에서, 용매가 에타놀인 방법.
  7. 제3항에서, 케토니트릴을 유기용매중에서 암모니움 설페이트가 아닌 암모니움염의 존재하에 적어도 1당량의 암모니아로 처리하는 방법.
  8. 제7항에서, 암모니움염이 암모니움 나이트레이트인 방법.
  9. 제8항에서, 용매가 에타놀이고 반응을 약 80℃에서 약 16시간 행하며, 암모니움 나이트레이트 1당량을 사용하는 방법.
  10. 제8항에서, 반응을 가압하에 암모니아 1-2당량을 사용하여 약 4-24시간 행하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840003388A 1983-06-20 1984-06-15 3-치환-3-아미노니트릴의 제조방법 KR870001538B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50617583A 1983-06-20 1983-06-20
US506.175 1983-06-20
US506,175 1983-06-20

Publications (2)

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KR850001157A true KR850001157A (ko) 1985-03-16
KR870001538B1 KR870001538B1 (ko) 1987-09-02

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KR1019840003388A KR870001538B1 (ko) 1983-06-20 1984-06-15 3-치환-3-아미노니트릴의 제조방법

Country Status (9)

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EP (1) EP0135252A3 (ko)
JP (1) JPS6013749A (ko)
KR (1) KR870001538B1 (ko)
BR (1) BR8402997A (ko)
DK (1) DK296984A (ko)
GB (1) GB2141712A (ko)
GR (1) GR82370B (ko)
HU (1) HUT34315A (ko)
IL (1) IL72092A0 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0027569D0 (en) * 2000-11-10 2000-12-27 Zeneca Ltd Chemical processes
JP2009130248A (ja) * 2007-11-27 2009-06-11 Nippon Seiki Co Ltd 放熱装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204517A1 (es) * 1972-12-01 1976-02-12 Sandoz Ag Procedimiento para obtener compuestos de 5-ciano-2-amino-tiofenos
US3970622A (en) * 1975-11-24 1976-07-20 American Cyanamid Company Heat stabilizers for polyvinyl chloride (β-amino-β-arylacrylonitriles)
DE2727528A1 (de) * 1977-06-18 1979-01-04 Bayer Ag N-(1-cyanalken-2-yl)-alpha-aminoessigsaeuren deren herstellungsverfahren sowie verfahren zur herstellung von beta -lactamantibiotika
MA19269A1 (fr) * 1980-09-16 1982-04-01 Lilly Co Eli Perfectionnement relatif a des derives de n-arylbenzamides .

Also Published As

Publication number Publication date
EP0135252A3 (en) 1985-07-10
GR82370B (ko) 1984-12-13
JPS6013749A (ja) 1985-01-24
BR8402997A (pt) 1985-05-28
HUT34315A (en) 1985-03-28
KR870001538B1 (ko) 1987-09-02
DK296984A (da) 1984-12-21
IL72092A0 (en) 1984-10-31
GB8415126D0 (en) 1984-07-18
EP0135252A2 (en) 1985-03-27
GB2141712A (en) 1985-01-03
DK296984D0 (da) 1984-06-18

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