KR850000972A - 지용성 약제 물질을 함유한 수용액 - Google Patents

지용성 약제 물질을 함유한 수용액 Download PDF

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KR850000972A
KR850000972A KR1019840004382A KR840004382A KR850000972A KR 850000972 A KR850000972 A KR 850000972A KR 1019840004382 A KR1019840004382 A KR 1019840004382A KR 840004382 A KR840004382 A KR 840004382A KR 850000972 A KR850000972 A KR 850000972A
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aqueous solution
water
fat
neutral amino
soluble active
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KR1019840004382A
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KR890000700B1 (ko
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히로유끼 오오하시 (외 6)
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나이또오 유우지
에이자이 가부시기 가이샤
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    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
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Abstract

내용 없음

Description

지용성 약제 물질을 함유한 수용액
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 수소화 레시틴과 그것에 결합된 중성아미노산을 함유하며 수용액의 pH가 5.5 내지 8의 범위인 지용성 활성 비타민 물질 및 또는 유비퀴논을 함유한 수용액.
  2. 제1항에 있어서, 수소화 레시틴이 지용성 활성 비타민 물질 및 또는 유비퀴논의 중량부당 0.1 내지 15 중량부의 양으로 포함되는 수용액.
  3. 제1항에 있어서, 수소화 레시틴이 최소한 85%의 포스포리피드 성분을 함유하고 10-60의 요오드값을 가지는 수용액.
  4. 제3항에 있어서, 수소화 레시틴이 수소화 소이비안 레시틴 또는 수소화 오보레시틴인 수용액.
  5. 제1항에 있어서, 중성 아미노산이 수용액의 0.05-6wt/vol%의 양으로 함유되는 수용액.
  6. 제5항에 있어서, 중성 아미노산이 글리신, 알라닌, β-알라닌, 성린, 트레오닌, 바린, 이소로이신, 로이신, 페닐 알라닌, 메티오닌, 히스티딘과 타우린으로부터 선택된 하나 이상의 중성 아미노산인 수용액.
  7. 제1항에 있어서, 수용액이 부수적으로 물과 혼합될 수 있는 용매 및 또는 등장제를 함유하는 수용액.
  8. 제7항에 있어서, 물과 혼합될 수 있는 용매가 에탄올, 프로필렌 글리콜, 저분자량의 폴리에틸렌 글리콜 또는 글리성린의 수용액.
  9. 제7항에 있어서, 물과 혼합될 수 있는 용매가 지용성 활성 비타민 물질 및 또는 유비퀴논의 중량부당 1-50중량부의 양으로 함유되는 수용액.
  10. 제7항에 있어서, 등장제가 당 또는 당 알콜인 수용액.
  11. 제10항에 있어서, 등장제가 글루코즈, 크실리톨, 소르비톨 또는 만나톨인 수용액.
  12. 제10항에 있어서, 등장제가 수용액의 0.05-6wt/vol%의 양으로 함유되는 수용액.
  13. 지용성 활성 비타민 물질 및 또는 유비퀴논과 수소화 레시틴을 물에 가하여 산출된 혼합물을 분산시키고 중성 아미노산을 가하는 것을 특징으로 하는 지용성 활성 약제물질을 함유하는 수용액의 제조방법.
  14. 제13항에 있어서, 일부의 물이 물과 혼합될 수 있는 용매로 대치되는 방법.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840004382A 1983-07-25 1984-07-24 지용성 약제물질을 함유한 수용액의 제조방법 KR890000700B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58-134260 1983-07-25
JP58134260A JPS6025918A (ja) 1983-07-25 1983-07-25 脂溶性薬物含有水性液

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KR850000972A true KR850000972A (ko) 1985-03-14
KR890000700B1 KR890000700B1 (ko) 1989-03-27

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US (1) US4840970A (ko)
EP (1) EP0132821B1 (ko)
JP (1) JPS6025918A (ko)
KR (1) KR890000700B1 (ko)
AT (1) ATE41307T1 (ko)
CA (1) CA1218598A (ko)
DE (1) DE3477137D1 (ko)
ES (1) ES534598A0 (ko)
NO (1) NO166835C (ko)
PH (1) PH24125A (ko)
ZA (1) ZA845541B (ko)

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ES8600931A1 (es) 1985-10-16
PH24125A (en) 1990-03-05
DE3477137D1 (en) 1989-04-20
JPS6025918A (ja) 1985-02-08
NO166835C (no) 1991-09-11
ZA845541B (en) 1985-03-27
CA1218598A (en) 1987-03-03
KR890000700B1 (ko) 1989-03-27
EP0132821B1 (en) 1989-03-15
NO843002L (no) 1985-01-28
JPH0510327B2 (ko) 1993-02-09
EP0132821A2 (en) 1985-02-13
NO166835B (no) 1991-06-03
ES534598A0 (es) 1985-10-16
ATE41307T1 (de) 1989-04-15
US4840970A (en) 1989-06-20
EP0132821A3 (en) 1985-07-10

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