KR840009085A - 7-옥사바이시클로헵탄치환 프로스타그란딘 동족체 제조방법 - Google Patents

7-옥사바이시클로헵탄치환 프로스타그란딘 동족체 제조방법 Download PDF

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KR840009085A
KR840009085A KR1019840001248A KR840001248A KR840009085A KR 840009085 A KR840009085 A KR 840009085A KR 1019840001248 A KR1019840001248 A KR 1019840001248A KR 840001248 A KR840001248 A KR 840001248A KR 840009085 A KR840009085 A KR 840009085A
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South Korea
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compound
methyl
oxabicyclo
hept
process according
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KR1019840001248A
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English (en)
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에드워드 홀(외 1) 스티븐
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죠오지 제이. 코에서
이이. 아르. 스퀴부 앤드 산즈 인코오포레이티드
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Priority claimed from US06/474,913 external-priority patent/US4474803A/en
Application filed by 죠오지 제이. 코에서, 이이. 아르. 스퀴부 앤드 산즈 인코오포레이티드 filed Critical 죠오지 제이. 코에서
Publication of KR840009085A publication Critical patent/KR840009085A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

7-옥사바이시클로헵탄치환 프로스타그란딘 동족체 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (26)

  1. 다음 일반식(Ⅱ)의 화합물을 R1-OH 또는 R1-SH 기토에테트화시키거나 티오에테르화시키는 것을 특징으로 하는 다음 일반식(Ⅰ)의 화합물 및 그 입체이성체들의 제조방법.
  3. 위의 일반식(Ⅰ)에서, A는 -CH=CH- 또는 -(CH2)2-이고, B는 산소 (-O-) 또는이며, m는 1-8이고, n는 1-4이며, R는 수소, 알킬, 알칼리금속 또는 트리스(히드록시메틸) 아미노메탄이고, R1은 알킬, 알케닐, 알키닐, 아릴, 아랄킬, 아랄케닐, 아랄키닐, 시클로알킬, 시클로알킬알케닐 또는 시클로알킬알키닐임.
  4. 제1항에 있어서, B가 -O-임을 특징으로 하는 제조방법.
  5. 제1항에 있어서, B가 -S-임을 특징으로 하는 제조방단
  6. 제1-3항에 있어서, A가 -CH=CH-임을 특징으로 하는 제조방법.
  7. 제1-3항에 있어서, R가 H임을 특징으로 하는 제조방법.
  8. 제1-3항에 있어서, n가 1임을 특징으로 하는 제조방법.
  9. 제1-3항에 있어서, n가 2임을 특징으로 하는 제조방법.
  10. 제1-3항에 있어서, n가 3또는 4임을 특징으로 하는 제조방법.
  11. 제1-3항에 있어서, A가 -CH=CH-이고, m가 2-4이며, m가 1 또는 2이고, R가 H이며 R1가 저급알킬 또는 시클로알킬임을 특징으로 하는 제조방법.
  12. 제1-3항에 있어서, A는 -CH=CH-이고, m가 3이며, n는 1이고, R는 H, CH3또는 C6H13이며 R1가 저급알킬임을 특징으로 하는 제조방법.
  13. 제1항에 있어서, 목적하는 화합물이〔1β,2α(5Z),3α,4β〕-7-〔3-〔(헥실옥시)메틸〕-7-옥사비이시클로〔2.2.1〕헵트-2-〕-5-헵테노산 또는 그의 헬실에스테트인 제조방법.
  14. 제1항에 있어서, 목적하는 화합물이〔1β,2α(5Z),3α,4β〕-7-〔3-〔2-(펜틸옥시)메틸〕-7-옥사비이시클로〔2.2.1〕헵트-2-〕-5-헵테노산인 제조방법.
  15. 제1항에 있어서, 목적하는 화합물이〔1β,2α(5Z),3α,4β〕-7-〔3-페닐프로폭시)메틸〕-7-옥사비이시클로〔2.2.1〕헵트-2-일〕-5-헵테노인 제조방법.
  16. 제1항에 있어서, 목적하는 화합물이〔1β,2α(5Z),3α,4β〕-7-〔3-(옥틸옥시)메틸〕-7-옥사비이시클로〔2.2.1〕헵트-2-일〕-5-헵테노산인 제조방법.
  17. 제1항에 있어서, 목적하는 화합물이〔1β,2α(5Z),3α,4β〕-7-〔3-〔(시클로헥실메톡시)메틸〕-7-옥사비이시클로〔2.2.1〕헵트-2-일〕-5-헵테노산인 제조방법.
  18. 제1항에 있어서, A가 -CH=CH-이고, m가 3이며, n가 1이고, n´가 1이며 R1가 저급알킬인 제조방법.
  19. 제1항에 있어서, A가 -CH=CH-이고, m가 3이며, n가 1이고, n´가 2이며 R1가 저급알킬인 제조방법.
  20. 제1항에 있어서, 목적하는 화합물이〔1β,2α(5Z),3α,4β〕-7-〔3-〔(헥실옥시)메틸〕-7-옥사비이시클로〔2.2.1〕헵트-2-일〕-5-헵테노산 또는 그의 메틸에스테트인 제조방법.
  21. 제1항에 있어서, 목적하는 화합물이〔1β,2α(5Z),3α,4β〕-7-〔3-〔(헥실술피닐)메틸〕-7-옥사비이시클로〔2.2.1〕헵트-2-일〕-5-헵테노산 또는 그의 메틸에스테트인 제조방법.
  22. 제1항에 있어서, 목적하는 화합물이〔1β,2α(5Z),3α,4β〕-7-〔3-〔(헥실술포닐)메틸〕-7-옥사비이시클로〔2.2.1〕헵트-2-일〕-7-오헵테노산 또는 그의 메틸에스테트인 제조방법.
  23. 제1항에 있어서, 목적하는 화합물이〔1β,2α(5Z),3α,4β〕-7-〔3-〔(시클로헥실메틸)티오)메틸〕-7-옥사비이시클로〔2.2.1〕헵트-2-일〕-5-헵테노산 또는 그의 헬실에스테트인 제조방법.
  24. 제1항에 있어서, 목적하는 화합물이〔1β,2α(5Z),3α,4β〕-7-〔3-〔〔(2-페닐에틸)티오)메틸〕-7-옥사비이시클로〔2.2.1〕헵트-2-〕-5-헵테노산 또는 그의 헬실에스테트인 제조방법.
  25. 제1항에 있어서, 목적하는 화합물이 〔1β,2α(5Z),3α,4β〕-7-〔〔(3-페닐프로필)티오)메틸〕-7-옥사비이시클로〔2.2.1〕헵트-2-일〕-5-헵테노산 또는 그의 메틸에스테트인 제조방법.
  26. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840001248A 1983-03-14 1984-03-13 7-옥사바이시클로헵탄치환 프로스타그란딘 동족체 제조방법 KR840009085A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US474913 1983-03-14
US06/474,913 US4474803A (en) 1983-03-14 1983-03-14 7-Oxabicycloheptane substituted thio prostaglandin analogs useful in treating platelet aggregation and bronchoconstriction
US52332083A 1983-08-15 1983-08-15
US523320 1990-05-14

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KR840009085A true KR840009085A (ko) 1984-12-24

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KR (1) KR840009085A (ko)
AT (1) AT383600B (ko)
AU (1) AU567919B2 (ko)
CA (1) CA1256887A (ko)
CH (1) CH658247A5 (ko)
DD (1) DD216932A5 (ko)
DE (1) DE3409124A1 (ko)
DK (1) DK155584A (ko)
ES (1) ES8506270A1 (ko)
FI (1) FI841008A (ko)
FR (1) FR2542743B1 (ko)
GB (1) GB2136428B (ko)
GR (1) GR79881B (ko)
HU (1) HU190530B (ko)
IE (1) IE57027B1 (ko)
IL (1) IL71184A0 (ko)
IT (1) IT1173442B (ko)
LU (1) LU85249A1 (ko)
NL (1) NL8400797A (ko)
NO (1) NO840960L (ko)
NZ (1) NZ207361A (ko)
PL (1) PL246663A1 (ko)
PT (1) PT78242B (ko)
SE (1) SE8401398L (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513103A (en) * 1983-10-21 1985-04-23 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane ethers useful in the treatment of thrombolytic disease
US4526900A (en) * 1984-01-26 1985-07-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease
US4542157A (en) * 1984-04-27 1985-09-17 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease
US4560698A (en) * 1984-06-04 1985-12-24 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment in thrombolytic disease
US4661506A (en) * 1984-11-30 1987-04-28 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted ox prostaglandin analogs
US4588743A (en) * 1985-01-22 1986-05-13 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane-substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease
US4607049A (en) * 1985-04-22 1986-08-19 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted thio prostaglandin analogs useful in the treatment of thrombolytic disease
US4608386A (en) * 1985-04-26 1986-08-26 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane ethers useful in the treatment of thrombotic diseases
US4611006A (en) * 1985-06-28 1986-09-09 E. R. Squibb & Sons, Inc. 5,6-epoxy-7-oxabicycloheptane substituted ethers useful in the treatment of thrombotic disease
US4654356A (en) * 1985-08-01 1987-03-31 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted diacid diamide prostaglandin analogs
US4673685A (en) * 1986-07-23 1987-06-16 E. R. Squibb & Sons, Inc. Hydroximic acids of 7-oxabicycloheptane substituted ethers and thioethers useful in the treatment of thrombotic disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
ZA814307B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
EP0082646B1 (en) * 1981-12-23 1989-11-15 National Research Development Corporation Prostaglandins
US4549030A (en) * 1982-12-13 1985-10-22 The Upjohn Company Organic compounds and process
US4526900A (en) * 1984-01-26 1985-07-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease
US4542157A (en) * 1984-04-27 1985-09-17 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease

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Publication number Publication date
GB8406100D0 (en) 1984-04-11
LU85249A1 (fr) 1984-11-14
IL71184A0 (en) 1984-06-29
IE840525L (en) 1984-09-14
NO840960L (no) 1984-09-17
AU567919B2 (en) 1987-12-10
DD216932A5 (de) 1985-01-02
GB2136428A (en) 1984-09-19
AT383600B (de) 1987-07-27
DE3409124A1 (de) 1984-09-27
ATA83484A (de) 1986-12-15
HU190530B (en) 1986-09-29
GB2136428B (en) 1986-09-10
ES530548A0 (es) 1985-07-01
IE57027B1 (en) 1992-03-25
FI841008A (fi) 1984-09-15
FI841008A0 (fi) 1984-03-13
SE8401398L (sv) 1984-09-15
IT1173442B (it) 1987-06-24
CH658247A5 (fr) 1986-10-31
GR79881B (ko) 1984-10-31
IT8420049A0 (it) 1984-03-14
AU2523584A (en) 1984-09-20
ES8506270A1 (es) 1985-07-01
HUT34179A (en) 1985-02-28
PT78242B (en) 1986-05-27
NL8400797A (nl) 1984-10-01
CA1256887A (en) 1989-07-04
PL246663A1 (en) 1985-03-26
NZ207361A (en) 1986-12-05
DK155584A (da) 1984-09-15
FR2542743B1 (fr) 1987-10-30
FR2542743A1 (fr) 1984-09-21
SE8401398D0 (sv) 1984-03-13
PT78242A (en) 1984-04-01
DK155584D0 (da) 1984-03-13

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