KR840003004A - 이미다졸 유도체의 제조방법 - Google Patents
이미다졸 유도체의 제조방법 Download PDFInfo
- Publication number
- KR840003004A KR840003004A KR1019830000300A KR830000300A KR840003004A KR 840003004 A KR840003004 A KR 840003004A KR 1019830000300 A KR1019830000300 A KR 1019830000300A KR 830000300 A KR830000300 A KR 830000300A KR 840003004 A KR840003004 A KR 840003004A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- hydrogen
- acid addition
- agent
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- 150000002460 imidazoles Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 231100000331 toxic Toxicity 0.000 claims 3
- 230000002588 toxic effect Effects 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 244000078703 ectoparasite Species 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- -1 or C 1 to C 4 alkyl Chemical group 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 230000000895 acaricidal effect Effects 0.000 claims 1
- 239000000642 acaricide Substances 0.000 claims 1
- 230000002141 anti-parasite Effects 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 239000003139 biocide Substances 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000004495 emulsifiable concentrate Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 230000008029 eradication Effects 0.000 claims 1
- 230000000749 insecticidal effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Agronomy & Crop Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 다음 일반식(I)의 화합물 또는 그의 생리적으로 무독한 산부가염을 희석제 또는 담체와 혼합함을 특징으로하여 외부기생충 박멸제, 특히 살응애제, 또는 구충제 조성물을 제조하는 방법.상기식에서, (R)n은 5개까지의 임의 치환체를 나타내며, n은 0또는 1내지 5의 정수이고, R은 각각 독립적으로 수소, 할로, 또는 C1내지 C4알킬, C1내지 C4알콕시 또는 퍼플루오로알킬그룹을 나타내며, 또는 인접한 2개의 R그룹은 함께-(CH2)3-또는-(CH2)4)-를 형성할 수 있고, m은 0,1 또는 2이며, R1은 수소 또는 C1내재 C6알킬그룹이다.
- 다음 일반식(Ⅳ)의 화합물을 수용성 산과 반응시키고, 일반식(I)의 화합물을 분리하여, 경우에 따라 그의 생리적으로 무독한 산부가염을 제조함을 특징으로 하여, m이 0이고 R1이 수소인 경우에(R)n은 수소, 모노-또는 2,4-또는 3,4-디클로로, 4-메톡시 또는 2,4-디메틸일 수 없는 일반식(I)의 화합물 또는 그의 생리적으로 무독한 산부가염을 제조하는 방법.상기식에서, R,R1,n 및 m은 제1항에서 정의한 바와 같으며, R3는 C1내지 C4알킬그룹이다.
- 제2항에 있어서, 반응을 90내지 100℃에서 염산 수용액을 사용하여 수행하는 방법.
- 제2항 또는 3항에 있어서, R이 할로 또는 C1내지 C4알킬임을 특징으로 하는 방법.
- 제4항에 있어서, (R)n이 2,3-디메틸이고, R1이 수소 또는 메틸이며, m은 0임을 특징으로 하는 방법.
- 제1항에 있어서 정의한 일반식(I)의 화합물 또는 그의 생리적으로 무독한 산부가염 및 희석제 또는 담체로 이루어진 외부기생충 박멸제, 특힐 상응애제, 또는 구충제 조성물.
- 제6항에 있어서 유화성 농축물,분제, 분산용분말, 주사제, 서방성 거환제 또는 수용성 유제 형태인 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8202329 | 1982-01-27 | ||
| US2329 | 1982-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840003004A true KR840003004A (ko) | 1984-08-13 |
Family
ID=10527916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830000300A KR840003004A (ko) | 1982-01-27 | 1983-01-26 | 이미다졸 유도체의 제조방법 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0086043A1 (ko) |
| JP (1) | JPS58128380A (ko) |
| KR (1) | KR840003004A (ko) |
| AU (1) | AU535094B2 (ko) |
| BR (1) | BR8300377A (ko) |
| DD (1) | DD208611A5 (ko) |
| DK (1) | DK29583A (ko) |
| ES (1) | ES518818A0 (ko) |
| FI (1) | FI830224L (ko) |
| GR (1) | GR77893B (ko) |
| IE (1) | IE830142L (ko) |
| NO (1) | NO830257L (ko) |
| PL (1) | PL240271A1 (ko) |
| PT (1) | PT76142B (ko) |
| ZA (1) | ZA83478B (ko) |
| ZW (1) | ZW1983A1 (ko) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851423A (en) * | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
| US5750532A (en) * | 1986-12-10 | 1998-05-12 | Schering Corporation | Pharmaceutically active compounds |
| ES2054725T3 (es) * | 1987-04-21 | 1994-08-16 | Basf Ag | Heteroaromatos anulares de cinco miembros de p-fenoxi-fenoximetilo. |
| US5212194A (en) * | 1988-07-29 | 1993-05-18 | Basf Aktiengesellschaft | Phenoxyalkyl-substituted heteroaromatics and a method for controlling pests |
| DE3842798A1 (de) * | 1988-12-20 | 1990-06-21 | Hoechst Ag | Imidazolinderivate enthaltende mittel zur wirtstiersystemischen bekaempfung von ektoparasiten sowie neue imidazolinderivate |
| KR920701167A (ko) * | 1989-07-07 | 1992-08-11 | 에릭 에스. 딕커 | 약제학적 활성 화합물 |
| JP2010513238A (ja) | 2006-12-13 | 2010-04-30 | エフ．ホフマン−ラ ロシュ アーゲー | 微量アミン関連受容体（ｔａａｒ）に対するリガンドとしての新規２−イミダゾール |
| WO2009003868A2 (en) | 2007-07-02 | 2009-01-08 | F. Hoffmann-La Roche Ag | 2 -imidazolines having a good affinity to the trace amine associated receptors (taars) |
| AU2008281918A1 (en) | 2007-07-27 | 2009-02-05 | F. Hoffmann-La Roche Ag | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands |
| EP2185502A1 (en) | 2007-08-03 | 2010-05-19 | F. Hoffmann-Roche AG | Pyridinecarboxamide and benzamide derivatives as taar1 ligands |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| PT3430010T (pt) | 2016-03-17 | 2020-09-10 | Hoffmann La Roche | Derivado de 5-etiol-4-metil-pirazol-3-carboxamida com atividade de agonista de taar |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EG11928A (en) * | 1974-12-16 | 1979-03-31 | Hoechst Ag | Process for preparing of 1-alkyl-2-(phenoxy-methyl)-5-nitro-imidazoles |
-
1983
- 1983-01-07 ES ES518818A patent/ES518818A0/es active Granted
- 1983-01-18 EP EP83300222A patent/EP0086043A1/en not_active Withdrawn
- 1983-01-24 FI FI830224A patent/FI830224L/fi not_active Application Discontinuation
- 1983-01-24 PL PL24027183A patent/PL240271A1/xx unknown
- 1983-01-25 ZA ZA83478A patent/ZA83478B/xx unknown
- 1983-01-25 IE IE830142A patent/IE830142L/xx unknown
- 1983-01-25 DD DD83247458A patent/DD208611A5/de unknown
- 1983-01-25 ZW ZW19/83A patent/ZW1983A1/xx unknown
- 1983-01-26 GR GR70338A patent/GR77893B/el unknown
- 1983-01-26 BR BR8300377A patent/BR8300377A/pt unknown
- 1983-01-26 AU AU10771/83A patent/AU535094B2/en not_active Ceased
- 1983-01-26 NO NO830257A patent/NO830257L/no unknown
- 1983-01-26 PT PT76142A patent/PT76142B/pt unknown
- 1983-01-26 KR KR1019830000300A patent/KR840003004A/ko not_active Application Discontinuation
- 1983-01-26 DK DK29583A patent/DK29583A/da not_active Application Discontinuation
- 1983-01-27 JP JP58012082A patent/JPS58128380A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58128380A (ja) | 1983-07-30 |
| GR77893B (ko) | 1984-09-25 |
| AU535094B2 (en) | 1984-03-01 |
| EP0086043A1 (en) | 1983-08-17 |
| BR8300377A (pt) | 1983-10-25 |
| ES8405770A1 (es) | 1984-06-16 |
| FI830224L (fi) | 1983-07-28 |
| PL240271A1 (en) | 1983-08-15 |
| ES518818A0 (es) | 1984-06-16 |
| DK29583A (da) | 1983-07-28 |
| DD208611A5 (de) | 1984-04-04 |
| ZA83478B (en) | 1983-12-28 |
| ZW1983A1 (en) | 1983-05-25 |
| IE830142L (en) | 1983-07-27 |
| AU1077183A (en) | 1983-08-11 |
| FI830224A0 (fi) | 1983-01-24 |
| PT76142A (en) | 1983-02-01 |
| NO830257L (no) | 1983-07-28 |
| PT76142B (en) | 1986-01-24 |
| DK29583D0 (da) | 1983-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |