KR840002427B1 - 모르폴린 유도체의 제조방법 - Google Patents

모르폴린 유도체의 제조방법 Download PDF

Info

Publication number
KR840002427B1
KR840002427B1 KR1019800003997A KR800003997A KR840002427B1 KR 840002427 B1 KR840002427 B1 KR 840002427B1 KR 1019800003997 A KR1019800003997 A KR 1019800003997A KR 800003997 A KR800003997 A KR 800003997A KR 840002427 B1 KR840002427 B1 KR 840002427B1
Authority
KR
South Korea
Prior art keywords
ethyl
ether
methoxyphenyl
mixture
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019800003997A
Other languages
English (en)
Korean (ko)
Other versions
KR830004277A (ko
Inventor
챔프먼 화이트 앨런
트레버 에딩톤 에드윈
Original Assignee
존 와이어스 앤드 브라더 리미티드
데이빗 이. 기벤즈
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 존 와이어스 앤드 브라더 리미티드, 데이빗 이. 기벤즈 filed Critical 존 와이어스 앤드 브라더 리미티드
Publication of KR830004277A publication Critical patent/KR830004277A/ko
Priority to KR1019840006196A priority Critical patent/KR840002428B1/ko
Application granted granted Critical
Publication of KR840002427B1 publication Critical patent/KR840002427B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Hydrogenated Pyridines (AREA)
KR1019800003997A 1979-10-20 1980-10-18 모르폴린 유도체의 제조방법 Expired KR840002427B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840006196A KR840002428B1 (ko) 1979-10-20 1984-10-06 모르폴린 유도체의 제조방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7936502 1979-10-20
GB7936502 1979-10-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019840006196A Division KR840002428B1 (ko) 1979-10-20 1984-10-06 모르폴린 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR830004277A KR830004277A (ko) 1983-07-09
KR840002427B1 true KR840002427B1 (ko) 1984-12-27

Family

ID=10508675

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019800003997A Expired KR840002427B1 (ko) 1979-10-20 1980-10-18 모르폴린 유도체의 제조방법
KR1019840006196A Expired KR840002428B1 (ko) 1979-10-20 1984-10-06 모르폴린 유도체의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019840006196A Expired KR840002428B1 (ko) 1979-10-20 1984-10-06 모르폴린 유도체의 제조방법

Country Status (17)

Country Link
US (1) US4360519A (enExample)
EP (1) EP0027695B1 (enExample)
JP (1) JPS5665880A (enExample)
KR (2) KR840002427B1 (enExample)
AT (1) ATE4980T1 (enExample)
AU (1) AU531586B2 (enExample)
CA (1) CA1126731A (enExample)
DE (1) DE3065304D1 (enExample)
DK (1) DK151800C (enExample)
ES (1) ES8107201A1 (enExample)
FI (1) FI803277A7 (enExample)
GB (1) GB2061272B (enExample)
GR (1) GR70235B (enExample)
IE (1) IE50355B1 (enExample)
MY (1) MY8500468A (enExample)
PT (1) PT71940B (enExample)
ZA (1) ZA806017B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2125793B (en) * 1982-08-19 1985-10-02 Wyeth John & Brother Ltd Morpholine derivatives
GB8305638D0 (en) * 1983-03-01 1983-03-30 Wyeth John & Brother Ltd Morpholine derivatives
FR2553412B1 (fr) * 1983-10-17 1986-03-21 Lafon Labor Derives de 4-alkyl-2-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique
GB8418657D0 (en) * 1984-07-21 1984-08-22 Beecham Group Plc Compounds
FR2581383A1 (fr) * 1985-05-03 1986-11-07 Cerm Cent Europ Rech Mauvernay 2-alkyl-2-aryl morpholines substituees, leur preparation et les compositions pharmaceutiques les contenant
DE3621775A1 (de) * 1986-03-13 1988-01-07 Thomae Gmbh Dr K Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9108629D0 (en) * 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
US5637699A (en) * 1992-06-29 1997-06-10 Merck & Co., Inc. Process for preparing morpholine tachykinin receptor antagonists
US5719147A (en) * 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US6048859A (en) 1992-06-29 2000-04-11 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
TW385308B (en) * 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
DK0821671T3 (da) * 1995-04-20 2001-04-23 Pfizer Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
KR20050088194A (ko) * 2002-12-19 2005-09-02 머크 앤드 캄파니 인코포레이티드 치환된 아미드
SI2332921T1 (sl) 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
EP2518053A1 (en) 2006-04-03 2012-10-31 Arena Pharmaceuticals, Inc. Process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
EP2099743B1 (en) 2006-12-05 2014-08-27 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
JP5491421B2 (ja) 2008-03-04 2014-05-14 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
JP2013526583A (ja) 2010-05-21 2013-06-24 リサーチ・トライアングル・インスティチュート フェニルモルホリンおよびその類似体
WO2011146821A2 (en) 2010-05-21 2011-11-24 Research Triangle Institute 1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
WO2012030957A2 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
MX2013002422A (es) 2010-09-01 2013-05-17 Arena Pharm Inc Sales de lorcaserina con acidos opticamente activos.
CN103347523A (zh) 2010-09-01 2013-10-09 艾尼纳制药公司 向具有肾损伤的个体给药氯卡色林
KR20180118801A (ko) 2010-09-01 2018-10-31 에자이 알앤드디 매니지먼트 가부시키가이샤 체중 관리에 유용한 5-ｈｔ2ｃ 작동제의 변형-방출 투여 형태
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management
IL323029A (en) * 2023-05-16 2025-10-01 Springworks Therapeutics Inc Benzopiperazine and related analogs inhibit YAP/YAZ-TEAD

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2835669A (en) * 1958-05-20 Process for the production of substi-
US2997469A (en) * 1961-08-22 Preparation of substituted
GB773780A (en) 1953-07-01 1957-05-01 Albert Boehringer Improvements in or relating to the preparation of substituted morpholines
GB791416A (en) 1956-04-09 1958-03-05 Albert Boehringer Improvements in or relating to the production of substituted tetrahydrooxazines
US3112311A (en) * 1957-04-05 1963-11-26 Geigy Chem Corp 2-phenyl-5, 6-dimethyl-morpholines and 2-phenyl-5, 6-tetramethylene-morpholines
ES247829A1 (es) 1958-03-13 1960-03-16 Boehringer Sohn Ingelheim Procedimeinto para la obtencion de tetrahidro-oxazinas sustituidas
US3296076A (en) * 1962-06-11 1967-01-03 Boehringer Sohn Ingelheim Pilomotor shaving compositions and method of using same
GB1336732A (en) * 1970-10-28 1973-11-07 Istituto Gentili Spa Pisa Diethanolamine derivatives
GB1452701A (en) * 1974-05-07 1976-10-13 Ici Ltd Morpholine derivatives

Also Published As

Publication number Publication date
FI803277L (fi) 1981-04-21
GR70235B (enExample) 1982-09-01
KR840002428B1 (ko) 1984-12-27
DK151800B (da) 1988-01-04
IE50355B1 (en) 1986-04-02
AU531586B2 (en) 1983-09-01
ZA806017B (en) 1982-04-28
EP0027695A1 (en) 1981-04-29
PT71940A (en) 1980-11-01
KR830004277A (ko) 1983-07-09
GB2061272A (en) 1981-05-13
AU6292280A (en) 1981-04-30
EP0027695B1 (en) 1983-10-12
CA1126731A (en) 1982-06-29
US4360519A (en) 1982-11-23
DK441080A (da) 1981-04-21
ES496074A0 (es) 1981-10-01
ES8107201A1 (es) 1981-10-01
MY8500468A (en) 1985-12-31
ATE4980T1 (de) 1983-10-15
FI803277A7 (fi) 1981-04-21
GB2061272B (en) 1983-08-10
DE3065304D1 (en) 1983-11-17
IE801995L (en) 1981-04-20
DK151800C (da) 1988-06-06
PT71940B (pt) 1981-08-31
JPS5665880A (en) 1981-06-03

Similar Documents

Publication Publication Date Title
KR840002427B1 (ko) 모르폴린 유도체의 제조방법
EP0170213B1 (en) Glutarimide antianxiety and antihypertensive agents
CA1049511A (en) 2-tetrahydrofurfuryl-6,7-benzomorphanes, their acid addition salts, their use as pharmaceuticals and processes for their production
HU219911B (hu) Pirazolo-piridin-származékok, alkalmazásuk és ezeket tartalmazó gyógyászati készítmények
HU193161B (en) Process for preparing new n-alkyl-norscopines
HU190902B (en) Process for preparing 1-aryl-oxy-2,3,4,5-tetrahydro-3-benzazepine derivatives and acid addition salts thereof
CS258149B2 (en) Method of arylcyclobutylalkylamines production
HU198009B (en) Process for producing n-substituted-4-amino-3-hydroxy-butironitriles
AU697610B2 (en) 4-aminotetrahydrobenzisoxazole or -isothiazole compounds
US3225031A (en) Phenyl-benzazepines and methods for their manufacture
EP0077536B1 (en) 2'-substituted-spiro(benzofuran-2(3h),1'-cycloalkanes), a process for preparing same, pharmaceutical compositions containing such compounds and their use as medicaments
CA2275668A1 (en) Sulfonamide compounds having 5-ht receptor activity
EP0061900B1 (en) Morpholines
EP0404748B1 (en) Novel stereoisomers
US3884976A (en) 7-Amino norbornane derivatives
CA1131236A (en) 2,9-dioxatricyclo[4,3,1,0 su3,7 xx]decane derivatives, processes for their preparation and pharmaceutical compositions thereof
AU607966B2 (en) Pilocarpine derivatives
EP0061900A2 (en) Morpholines
US4054572A (en) Hexahydro pyridine [1,2d] dibenza [b,f] (1,4)-diazepines
US3202712A (en) 1-cyclohexene-4-bis (omicron-chlorobenzylaminomethyl) and derivatives
US4474782A (en) Alkenyl and alkynyl morpholine compounds, compositions and use
GB2117771A (en) Enantiomers of substituted phenylazacycloalkanes
JPH04211059A (ja) 新規なテトラヒドロピリジン誘導体
US4270000A (en) Process for preparing 3-phenoxy morphinans
JPS59184184A (ja) ７，８，９，１０−テトラヒドロチエノ〔３，２−ｅ〕ピリド〔４，３−ｂ〕−インド−ル、その製造法及びそれらを含む医薬

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19881228

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19881228