KR840000526A - 니코티노일 벤조구아나민유도체 및 그 산부가염류의 제조방법 - Google Patents

니코티노일 벤조구아나민유도체 및 그 산부가염류의 제조방법 Download PDF

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Publication number
KR840000526A
KR840000526A KR1019820002546A KR820002546A KR840000526A KR 840000526 A KR840000526 A KR 840000526A KR 1019820002546 A KR1019820002546 A KR 1019820002546A KR 820002546 A KR820002546 A KR 820002546A KR 840000526 A KR840000526 A KR 840000526A
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KR
South Korea
Prior art keywords
nicotinoyl
addition salts
acid addition
general formula
same
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KR1019820002546A
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English (en)
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KR880000807B1 (ko
Inventor
히로(시 외 3) 에노모도
Original Assignee
모리시다 히로무
닛본 신야구 가부시기 가이샤
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Publication of KR840000526A publication Critical patent/KR840000526A/ko
Application granted granted Critical
Publication of KR880000807B1 publication Critical patent/KR880000807B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음

Description

니코티노일 벤조구아나민유도체 및 그 산부가염류의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. 다음의 일반식
  3. (식중, X, Y는 동일 또는 다른 수소 또는 할로겐을 나타내고(단, X, Y가 동시에 수소일 경우를 제외함), Z는 모노 저급 알킬아미노, 디 저급 알킬아미노, 피페리딘, 피로리디노 또는 모르포리노를 나타낸다)
  4. 로 나타내는 벤조구아니민 유도체에 활성화 니코틴산 유도체를 반응시키는 것을 특징으로하는 다음의 일반식 (Ⅰ)
  6. (식중, X, Y, Z는 상기와 같음)
  7. 로 나타내는 니코티노일 벤조 구아나민 유도체 및 그들의 산부가염류의 제조법.
  8. 다음의 일반식 (Ⅲ)
  10. (식중, X, Y는 동일 또는 다른 수소 또는 할로겐을 나타내고(단, X, Y가 동시에 수소일 경우를 제외함), Z는 모노 저급 알킬아미노, 디저급 알킬아미노, 티페리디노, 피로리디노 또는 모르포리노를 나타낸다.)
  11. 로 나타내는 벤조구아나민 유도체에 니코틴 아미드 금속염을 작용시키는 것을 특징으로하는 다음의 일반식 (Ⅰ)
  13. (식중, X, Y, Z는 상기와 같음)
  14. 로 나타내는 니코티노일 벤조구아나민 유도체 및 이들의 산부가염류의 제조법.
  15. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8202546A 1981-06-05 1982-06-05 니코티노일 벤조구 아나민유도체 및 그 산부가염류의 제조방법 KR880000807B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP56087124A JPS57203083A (en) 1981-06-05 1981-06-05 Nicotinic acid derivative
JP87124 1981-06-05
JP56-87124 1981-06-05

Publications (2)

Publication Number Publication Date
KR840000526A true KR840000526A (ko) 1984-02-25
KR880000807B1 KR880000807B1 (ko) 1988-05-11

Family

ID=13906203

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8202546A KR880000807B1 (ko) 1981-06-05 1982-06-05 니코티노일 벤조구 아나민유도체 및 그 산부가염류의 제조방법

Country Status (7)

Country Link
US (1) US4415570A (ko)
EP (1) EP0066799B1 (ko)
JP (1) JPS57203083A (ko)
KR (1) KR880000807B1 (ko)
CA (1) CA1185972A (ko)
DE (1) DE3268253D1 (ko)
ES (1) ES512397A0 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59106473A (ja) * 1982-12-10 1984-06-20 Nippon Shinyaku Co Ltd トリアジン誘導体
MX9700928A (es) * 1994-08-08 1997-04-30 Nippon Shinyaku Co Ltd Derivado de triazian y medicina que lo contiene.
US5962453A (en) * 1995-08-08 1999-10-05 Nippon Shinyaku Co. Ltd. Triazine derivative and medicine
US7736636B2 (en) * 2003-02-12 2010-06-15 Shaker Mousa Method for treating occlusive vascular diseases & wound healing
WO2015155129A1 (en) * 2014-04-07 2015-10-15 Basf Se Diaminotriazine compound
CN105820133B (zh) * 2016-03-25 2018-06-05 浙江工业大学 多取代均三嗪类化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1052988A (ko) * 1962-07-03
GB1441904A (en) * 1974-02-18 1976-07-07 Nippon Shinyaku Co Ltd Benzoguanamine derivatives
JPS52118483A (en) * 1976-03-29 1977-10-04 Nippon Shinyaku Co Ltd Nicotinylaminotriazine derivatives
JPS5735587A (en) * 1980-06-04 1982-02-26 Nippon Shinyaku Co Ltd Benzoguanamine derivative
US4317822A (en) * 1980-07-02 1982-03-02 Merck & Co., Inc. 3-Amino-5-substituted-6-halo-N-(3,4-dihydro-6-substituted-1,3,5-triazin-2-yl)2-pyrazinecarboxamides

Also Published As

Publication number Publication date
DE3268253D1 (en) 1986-02-13
ES8307791A1 (es) 1983-08-01
US4415570A (en) 1983-11-15
CA1185972A (en) 1985-04-23
JPS57203083A (en) 1982-12-13
EP0066799A3 (en) 1983-01-26
EP0066799B1 (en) 1986-01-02
EP0066799A2 (en) 1982-12-15
ES512397A0 (es) 1983-08-01
KR880000807B1 (ko) 1988-05-11

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