KR840000238A - 위에 내성이 있는 크산틴 유도체 약학적 조성물 및 이의 제법 - Google Patents

위에 내성이 있는 크산틴 유도체 약학적 조성물 및 이의 제법 Download PDF

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Publication number
KR840000238A
KR840000238A KR1019820003047A KR820003047A KR840000238A KR 840000238 A KR840000238 A KR 840000238A KR 1019820003047 A KR1019820003047 A KR 1019820003047A KR 820003047 A KR820003047 A KR 820003047A KR 840000238 A KR840000238 A KR 840000238A
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South Korea
Prior art keywords
gastric juice
granules
resistant
gastric
dissolved
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KR1019820003047A
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English (en)
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KR880000971B1 (ko
Inventor
글라익스너 클라우스
Original Assignee
하인리히 벡커/베른하르트 벡크
훽스트 아크티엔 게젤샤프트
베른하르트 벡크
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6136567&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR840000238(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 하인리히 벡커/베른하르트 벡크, 훽스트 아크티엔 게젤샤프트, 베른하르트 벡크 filed Critical 하인리히 벡커/베른하르트 벡크
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Abstract

내용 없음

Description

위에 내성이 있는 크산틴 유도체 약학적 조성물 및 이의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 크산틴 유도체로 피복된 담체 펠렛 또는 과립을 위액에 내성이 있는 피복물질로 피복하고, 생성된 응집체를 제립기로 분쇄하고, 생성된 위액에 녹거나 부분적으로 녹는 과립을 위액에 내성이 있는 피복물로 피복된 과립과 혼합(위액에 녹거나 부분적으로 녹는 과립은 30% 이하로 함) 한다음 필요한 경우 생성된 혼합물을 캅셀 또는 소형외피에 충전시키거나 정제로 압축시켜, 크산린 유도체로서, (W-1)-알킬-, (W-1)-옥소알킬- 또는 (W-1)-하이드록시알킬-디알킬크산린(여기서 알킬, 옥소알킬 또는 하이드록시 알킬라디칼은 3 내지 7의 탄소수를 갖고 1- 또는 7-위치에 존재함중에서 선택되고 1- 또는 7-위치이외의 위치에 탄소수 1 내지 12의 알킬라디칼을 갖고 3-위치에 탄소수 1 내지 4의 알킬라디칼을 갖는 유도체를 함유하고; 위액에 내성이 있는 피복물은 수용액 또는 분산액 형태로 사용하며 과립부분만을 위액에 내성이 있는 피복물로 피복하고, 20 내지 50%의 크산틴 유도체, 30 내지 80%의 불활성 담체물질 및 5 내지 40%의 위액-불용성 피복물질을 함유하며, 위액에 녹거나 부분적으로 녹는 과립이 30% 이하인 약학적 조성물을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8203047A 1981-07-10 1982-07-08 위내 허용 가능한 크산틴 유도체 약제학적 조성물의 제조방법 KR880000971B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP3127237.1 1981-07-10
DEP31272371 1981-07-10
DE19813127237 DE3127237A1 (de) 1981-07-10 1981-07-10 Magenvertraegliche arzneiformen von xanthinderivaten und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
KR840000238A true KR840000238A (ko) 1984-02-18
KR880000971B1 KR880000971B1 (ko) 1988-06-07

Family

ID=6136567

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8203047A KR880000971B1 (ko) 1981-07-10 1982-07-08 위내 허용 가능한 크산틴 유도체 약제학적 조성물의 제조방법

Country Status (17)

Country Link
US (1) US4542011A (ko)
EP (1) EP0069958B2 (ko)
JP (1) JPS5818318A (ko)
KR (1) KR880000971B1 (ko)
AT (1) ATE18851T1 (ko)
AU (1) AU553925B2 (ko)
CA (1) CA1178204A (ko)
DD (1) DD202502A5 (ko)
DE (2) DE3127237A1 (ko)
DK (1) DK166758B1 (ko)
FI (1) FI81259C (ko)
HU (1) HU187774B (ko)
IE (1) IE53581B1 (ko)
IL (1) IL66282A (ko)
NO (1) NO157244C (ko)
PT (1) PT75217B (ko)
ZA (1) ZA824901B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55745B1 (en) * 1983-04-06 1991-01-02 Elan Corp Plc Sustained absorption pharmaceutical composition
DE3405378A1 (de) * 1984-02-15 1985-08-22 Röhm GmbH, 6100 Darmstadt Arzneimittelueberzug
DE3508097A1 (de) * 1984-07-21 1986-02-06 Hoechst Ag, 6230 Frankfurt Kombinationspraeparat aus xanthinderivaten und o-acetylsalicylsaeure bzw. deren pharmakologisch vertraeglichen salzen und dessen verwendung
DE3440288A1 (de) * 1984-11-05 1986-05-07 Gergely, Gerhard, Dr.-Ing., Wien Pharmazeutische zubereitung mit einem gehalt an mindestens einer schleimhautreizenden substanz oder dergleichen, insbesondere profen, sowie verfahren zu ihrer herstellung
US4971791A (en) * 1985-08-26 1990-11-20 The Procter & Gamble Company Taste masking compositions
US4994276A (en) * 1988-09-19 1991-02-19 Edward Mendell Co., Inc. Directly compressible sustained release excipient
US4874605A (en) * 1987-11-27 1989-10-17 Hoechst-Roussel Pharmaceuticals Inc. Stabilized delayed release emulsion
US5128143A (en) * 1988-09-19 1992-07-07 Edward Mendell Co., Inc. Sustained release excipient and tablet formulation
US5169639A (en) * 1988-09-19 1992-12-08 Edward Mendell Co., Inc. Controlled release verapamil tablets
US5135757A (en) * 1988-09-19 1992-08-04 Edward Mendell Co., Inc. Compressible sustained release solid dosage forms
DE3929864A1 (de) * 1989-09-08 1991-03-14 Nordmark Arzneimittel Gmbh Verfahren zur herstellung von theophyllin-pellets
US5472711A (en) * 1992-07-30 1995-12-05 Edward Mendell Co., Inc. Agglomerated hydrophilic complexes with multi-phasic release characteristics
IN186245B (ko) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
WO2013045352A1 (de) 2011-09-30 2013-04-04 Basf Se Verfahren zur herstellung von festen pigmenthaltigen filmüberzugsmitteln in form von granulaten auf basis von magensaftresistenten filmbildnern für pharmazeutische dosierungsformen

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US4064230A (en) * 1966-04-25 1977-12-20 Schmid Laboratories, Inc. Polyenic macrolide compositions
US4060598A (en) * 1967-06-28 1977-11-29 Boehringer Mannheim G.M.B.H. Tablets coated with aqueous resin dispersions
US3935326A (en) * 1967-06-28 1976-01-27 Boehringer Mannheim G.M.B.H. Process for coating tablets with aqueous resin dispersions
US3864469A (en) * 1967-12-16 1975-02-04 Hoechst Ag Xanthines in pharmaceutical preparations and for stabilization of vitamins
BE725125A (ko) * 1967-12-16 1969-06-09
IL45337A (en) * 1973-08-10 1977-04-29 Saarstickstoff Fatol Gmbh Therapeutical composition containing an isonicotinic acid hydrazide thioisonicotinic acid amide sulfones and/or sulfonamides for the treatment of mycobacterioses
DE2520978C3 (de) * 1975-05-10 1981-02-19 Hoechst Ag, 6000 Frankfurt Dosierungseinheit einer festen, oral zu verabreichenden Arzneiform von wasserlöslichen Xanthin-Derivaten
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DE2967632D1 (en) * 1978-04-22 1986-12-04 Beecham Wuelfing Gmbh & Co Kg Use of a xanthine derivate in the manufacture of a medicament
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Also Published As

Publication number Publication date
IL66282A (en) 1987-01-30
FI822441A0 (fi) 1982-07-08
US4542011A (en) 1985-09-17
DE3270241D1 (en) 1986-05-07
PT75217B (de) 1985-01-07
PT75217A (de) 1982-08-01
DK166758B1 (da) 1993-07-12
JPH0419969B2 (ko) 1992-03-31
FI822441L (fi) 1983-01-11
HU187774B (en) 1986-02-28
IE821661L (en) 1983-01-10
JPS5818318A (ja) 1983-02-02
EP0069958A2 (de) 1983-01-19
IE53581B1 (en) 1988-12-21
AU553925B2 (en) 1986-07-31
ZA824901B (en) 1983-04-27
ATE18851T1 (de) 1986-04-15
DD202502A5 (de) 1983-09-21
EP0069958B1 (de) 1986-04-02
NO157244B (no) 1987-11-09
NO822399L (no) 1983-01-11
FI81259C (fi) 1990-10-10
NO157244C (no) 1988-02-24
EP0069958B2 (de) 1991-03-27
AU8578082A (en) 1983-01-13
EP0069958A3 (en) 1983-06-29
IL66282A0 (en) 1982-11-30
KR880000971B1 (ko) 1988-06-07
DE3127237A1 (de) 1983-01-20
FI81259B (fi) 1990-06-29
DK310582A (da) 1983-01-11
CA1178204A (en) 1984-11-20

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