KR840000076B1 - 4-치환 아미노-3-카복시 또는 시아노-1, 2-디하이드로-2-옥소-1, 8-나프티리딘 유도체의 제조방법 - Google Patents

4-치환 아미노-3-카복시 또는 시아노-1, 2-디하이드로-2-옥소-1, 8-나프티리딘 유도체의 제조방법 Download PDF

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Publication number
KR840000076B1
KR840000076B1 KR1019800001587A KR800001587A KR840000076B1 KR 840000076 B1 KR840000076 B1 KR 840000076B1 KR 1019800001587 A KR1019800001587 A KR 1019800001587A KR 800001587 A KR800001587 A KR 800001587A KR 840000076 B1 KR840000076 B1 KR 840000076B1
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KR
South Korea
Prior art keywords
dihydro
oxo
naphthyridine
carbon atoms
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019800001587A
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English (en)
Korean (ko)
Other versions
KR830002759A (ko
Inventor
시이 스코티스 안토니
에이 산틸리 아디
Original Assignee
아메리칸 홈 프로덕츠 코포레이션
조지 드 모오
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아메리칸 홈 프로덕츠 코포레이션, 조지 드 모오 filed Critical 아메리칸 홈 프로덕츠 코포레이션
Publication of KR830002759A publication Critical patent/KR830002759A/ko
Application granted granted Critical
Publication of KR840000076B1 publication Critical patent/KR840000076B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019800001587A 1979-04-18 1980-04-17 4-치환 아미노-3-카복시 또는 시아노-1, 2-디하이드로-2-옥소-1, 8-나프티리딘 유도체의 제조방법 Expired KR840000076B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3125579A 1979-04-18 1979-04-18
US31255 1979-04-18
US06/125,600 US4324893A (en) 1979-04-18 1980-02-28 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
US125600 1980-02-28

Publications (2)

Publication Number Publication Date
KR830002759A KR830002759A (ko) 1983-05-30
KR840000076B1 true KR840000076B1 (ko) 1984-02-08

Family

ID=26707004

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800001587A Expired KR840000076B1 (ko) 1979-04-18 1980-04-17 4-치환 아미노-3-카복시 또는 시아노-1, 2-디하이드로-2-옥소-1, 8-나프티리딘 유도체의 제조방법

Country Status (22)

Country Link
US (1) US4324893A (https=)
EP (2) EP0060012B1 (https=)
JP (1) JPS56500373A (https=)
KR (1) KR840000076B1 (https=)
AR (2) AR225437A1 (https=)
AU (1) AU531348B2 (https=)
CA (1) CA1115272A (https=)
DK (1) DK537780A (https=)
ES (1) ES8104286A1 (https=)
FI (1) FI801229A7 (https=)
GB (1) GB2053198B (https=)
GR (1) GR67253B (https=)
HU (1) HU183125B (https=)
IE (1) IE49696B1 (https=)
IL (1) IL59667A (https=)
IN (1) IN150969B (https=)
NZ (1) NZ193445A (https=)
PH (1) PH16524A (https=)
PT (1) PT71081A (https=)
SU (1) SU1131469A3 (https=)
WO (1) WO1980002287A1 (https=)
YU (1) YU105680A (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4420615A (en) * 1981-08-24 1983-12-13 Merck & Co., Inc. Substituted pyridopyrimidines as gastric secretion inhibitors
FR2567520B1 (fr) * 1984-07-11 1987-01-02 Carpibem Nouvelles phenyl-naphthyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres
FR2592651B1 (fr) * 1986-01-06 1988-05-13 Carpibem Nouvelles phenyl naphtyridines comportant un substituant methyle en position 3, et les medicaments qui en contiennent.
NZ218774A (en) * 1986-01-06 1990-06-26 Carpibem 3-substituted phenylnaphthyridines and pharmaceutical compositions
FR2592650B1 (fr) * 1986-01-06 1988-04-29 Carpibem Nouvelles phenyl-naphtyridines fonctionnalisees en position-3, leur procede de preparation, medicaments les contenant, notamment anti-ulceres.
NZ218773A (en) * 1986-01-06 1990-05-28 Carpibem 3-methyl-2-oxo-1-(substituted phenyl)-naphthyridines and pharmaceutical compositions
FR2592652B1 (fr) * 1986-01-06 1988-04-29 Carpibem Nouvelles phenyl-naphtyridines, leur procede de preparation et les medicaments en contenant.
FR2592649B1 (fr) * 1986-01-06 1988-04-29 Carpibem Cyano et amido phenyl-naphtyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres.
EP0267691A3 (en) * 1986-10-15 1989-08-23 Schering Corporation Use of 1-substituted naphthyridine and pyridopyrazine derivatives for the preparation of medicaments with immunosuppressor activity.
US4916131A (en) * 1986-10-15 1990-04-10 Schering Corporation Naphthyridine derivatives and method for treating allergic reactions
US5037826A (en) * 1986-10-15 1991-08-06 Schering Corporation 1-substituted naphthyridine and pyridopyrazine derivatives
FR2632861B1 (fr) * 1988-06-15 1990-11-09 Sanofi Sa Derives d'amino-4 carboxy-3 quinoleines et naphtyridines, leur procede de preparation et leur application comme medicaments
DK273689A (da) * 1988-06-06 1989-12-07 Sanofi Sa 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler
FR2632639B1 (fr) * 1988-06-09 1990-10-05 Sanofi Sa Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent
FR2637890B1 (fr) * 1988-09-14 1991-02-01 Europ Propulsion Materiau composite a matrice zircone
GB9318931D0 (en) * 1993-09-14 1993-10-27 Boots Co Plc Therapeutic agents
GB9420168D0 (en) * 1994-10-06 1994-11-23 Boots Co Plc Therapeutic agents
TWI262919B (en) 1999-10-25 2006-10-01 Yamanouchi Pharma Co Ltd Naphthyridine derivative
UY27304A1 (es) 2001-05-24 2002-12-31 Avanir Pharmaceuticals Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación
KR20020092756A (ko) * 2001-06-05 2002-12-12 이종완 젓갈과 그 제조 방법
TW200418829A (en) 2003-02-14 2004-10-01 Avanir Pharmaceutics Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
WO2004091627A2 (en) * 2003-04-07 2004-10-28 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs
CN1839133A (zh) * 2003-08-22 2006-09-27 阿文尼尔药品公司 作为巨噬细胞移动抑制因子的抑制剂的取代的二氮杂萘衍生物及其在治疗人类疾病中的应用
WO2006102191A1 (en) 2005-03-24 2006-09-28 Avanir Pharmaceuticals Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors
GB0605689D0 (en) * 2006-03-21 2006-05-03 Novartis Ag Organic compounds
AU2018340475B2 (en) 2017-09-28 2023-01-19 Transthera Sciences (Nanjing), Inc. PDE9 inhibitor and use thereof
CN112585139B (zh) 2018-06-27 2023-12-01 百时美施贵宝公司 用作t细胞激活剂的萘啶酮化合物
KR102767739B1 (ko) 2018-06-27 2025-02-12 브리스톨-마이어스 스큅 컴퍼니 T 세포 활성화제로서 유용한 치환된 나프티리디논 화합물
AR119821A1 (es) 2019-08-28 2022-01-12 Bristol Myers Squibb Co Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t
BR112022012179A2 (pt) 2019-12-23 2022-09-06 Bristol Myers Squibb Co Compostos de quinazolina substituída úteis como ativadores de célula t
CA3162979A1 (en) 2019-12-23 2021-07-01 Upender Velaparthi Substituted piperazine derivatives useful as t cell activators
AR120823A1 (es) 2019-12-23 2022-03-23 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos útiles como activadores de células t

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA947301A (en) * 1970-01-28 1974-05-14 Sumitomo Chemical Company Process for the preparation of compound having antibacterial action
CA988522A (en) * 1972-05-05 1976-05-04 Haydn W.R. Williams 1,8-naphthyridine compounds
US3993656A (en) * 1974-11-19 1976-11-23 Merck & Co., Inc. 1,8-Naphthyridine compounds
US4103257A (en) * 1976-05-25 1978-07-25 The United States Of America As Represented By The United States Department Of Energy Azaquinolone dye lasers
US4133885A (en) * 1977-07-18 1979-01-09 Merck & Co., Inc. Substituted naphthyridinones

Also Published As

Publication number Publication date
NZ193445A (en) 1982-09-07
AU5751980A (en) 1980-10-23
HU183125B (en) 1984-04-28
EP0060012B1 (en) 1984-08-29
KR830002759A (ko) 1983-05-30
AU531348B2 (en) 1983-08-18
US4324893A (en) 1982-04-13
AR225437A1 (es) 1982-03-31
FI801229A7 (fi) 1981-01-01
ES490645A0 (es) 1981-04-16
WO1980002287A1 (en) 1980-10-30
CA1115272A (en) 1981-12-29
AR227427A1 (es) 1982-10-29
GR67253B (https=) 1981-06-26
PH16524A (en) 1983-11-10
GB2053198A (en) 1981-02-04
PT71081A (en) 1980-05-01
SU1131469A3 (ru) 1984-12-23
EP0018735A1 (en) 1980-11-12
EP0018735B1 (en) 1983-07-27
IE49696B1 (en) 1985-11-27
YU105680A (en) 1983-09-30
DK537780A (da) 1980-12-17
JPS56500373A (https=) 1981-03-26
ES8104286A1 (es) 1981-04-16
IN150969B (https=) 1983-02-05
GB2053198B (en) 1983-04-07
EP0060012A1 (en) 1982-09-15
IE800761L (en) 1980-10-18
IL59667A (en) 1983-11-30

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19800417

PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19830930

Patent event code: PE09021S01D

PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19840111

PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19840423