KR830007681A - 세파렉신의 수용성 유도체의 제조방법 - Google Patents

세파렉신의 수용성 유도체의 제조방법 Download PDF

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Publication number
KR830007681A
KR830007681A KR1019810003864A KR810003864A KR830007681A KR 830007681 A KR830007681 A KR 830007681A KR 1019810003864 A KR1019810003864 A KR 1019810003864A KR 810003864 A KR810003864 A KR 810003864A KR 830007681 A KR830007681 A KR 830007681A
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South Korea
Prior art keywords
general formula
solution
separexin
basic amino
preparing
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KR1019810003864A
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English (en)
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KR880000691B1 (ko
Inventor
라이너 알베트로
Original Assignee
리얼 에스. 에이. 에스. 디도트. 알베르토라이너 앤드씨.
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Application filed by 리얼 에스. 에이. 에스. 디도트. 알베르토라이너 앤드씨. filed Critical 리얼 에스. 에이. 에스. 디도트. 알베르토라이너 앤드씨.
Publication of KR830007681A publication Critical patent/KR830007681A/ko
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Publication of KR880000691B1 publication Critical patent/KR880000691B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

세파신의 수용성 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명에 의해서 제조한 2-N-메티롤-세파렉신의 리신염에 대한 핵자기공명 스텍트럼을 나타낸 것이며,
제2도는 본 발명에 의해서 제조한 2-N-메티롤-세파렉신의 나트륨염에 대한 핵자기공명 스팩트럼을 나타낸 것임.

Claims (5)

  1. 하기 일반식(II)를 가진 세파렉신의 메티롤 유도체를 제조함에 있어서,
    (상기 일반식(II)에서 X는 알칼리금속 또는 염기성 아미노산의 양이온을 포함하는 유기질소임)
    (a) 세파렉신의 수현탁액을 약 5°내지 10℃의 온도에서 격렬하게 교반하면서 포름알데히드 용액과 접촉시켜서 하기 일반식(III)을 가진 메티롤 유도체로 구성되는 상을 얻는 단계와
    (b) 단계(a)에서 얻은 반응혼합물을 일반식 XOH(여기서, X는 알칼리금속 양이온들중에서 선택한 양이온임)을 가진 유기염기의 수용액과 접촉시키거나 염기성 아미노산의 용액과 접촉시켜서 메티롤 유도체(II)의 용액을 얻는 단계들로 이루어지는 것이 특징인 제조방법.
  2. 특허청구의 범위 제1항 기재에 있어서, 단계(b)에서 얻은 용액을 냉동건조시켜서 일반식(II)를 가진 고체물질을 얻는 것이 특징인 방법.
  3. 특허청구의 범위 제4항 또는 5항 기재에 있어서 전기한 염기가 수산화나트륨인 것이 특징인 방법.
  4. 특허청구의 범위 제4항 또는 5항 기재에 있어서 전기한 염기성 아미노산이 리신과 아르기닌으로 구성되는 군에서 선택된 것이 특징인 방법.
  5. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810003864A 1980-10-13 1981-10-13 세팔렉신의 수용성 유도체의 제조 방법 KR880000691B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT25267/80A IT1195762B (it) 1980-10-13 1980-10-13 Derivati idrosolubili della cefalexina e procedimento per la loro produzione
IT25267A/80 1980-10-13

Publications (2)

Publication Number Publication Date
KR830007681A true KR830007681A (ko) 1983-11-04
KR880000691B1 KR880000691B1 (ko) 1988-04-23

Family

ID=11216176

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810003864A KR880000691B1 (ko) 1980-10-13 1981-10-13 세팔렉신의 수용성 유도체의 제조 방법

Country Status (17)

Country Link
US (1) US4471115A (ko)
EP (1) EP0049928B1 (ko)
JP (1) JPS5767583A (ko)
KR (1) KR880000691B1 (ko)
AR (1) AR229035A1 (ko)
AT (1) ATE35813T1 (ko)
AU (1) AU548333B2 (ko)
BE (1) BE890718A (ko)
CA (1) CA1181741A (ko)
DE (1) DE3176811D1 (ko)
DK (1) DK451281A (ko)
ES (1) ES8206533A1 (ko)
FR (1) FR2491927B1 (ko)
IT (1) IT1195762B (ko)
NO (1) NO813433L (ko)
PT (1) PT73807B (ko)
YU (1) YU246381A (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI811767B (zh) * 2018-02-28 2023-08-11 韓商畢利吉生物科技股份有限公司 脂化肽的水溶性鹽以及製備與使用其的方法
KR102104507B1 (ko) * 2019-08-23 2020-04-24 브릿지바이오테라퓨틱스(주) 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1265315A (ko) * 1968-04-05 1972-03-01 Glaxo Lab Ltd
BE786924A (fr) * 1971-07-28 1973-01-29 Squibb & Sons Inc Antibiotiques, leur preparation et leurs utilisations therapeutiques
US3796709A (en) * 1971-11-19 1974-03-12 Squibb & Sons Inc (alpha-cyanamino)acetamidocephalosporins
BE792229A (fr) * 1971-12-03 1973-06-01 Bristol Myers Co Agents antibacteriens heterocycliques azotes et procede pour les preparer
US3880842A (en) * 1972-05-30 1975-04-29 Squibb & Sons Inc Cephalosporin derivatives
US3988326A (en) * 1974-02-22 1976-10-26 Meiji Seika Kaisha, Ltd. Process for N-acylation of 7 amino cephem compounds

Also Published As

Publication number Publication date
AU7624781A (en) 1982-04-22
DK451281A (da) 1982-04-14
EP0049928B1 (en) 1988-07-20
ES506213A0 (es) 1982-08-16
BE890718A (fr) 1982-02-01
JPS5767583A (en) 1982-04-24
NO813433L (no) 1982-04-14
FR2491927B1 (fr) 1985-07-12
ES8206533A1 (es) 1982-08-16
CA1181741A (en) 1985-01-29
IT8025267A0 (it) 1980-10-13
PT73807A (fr) 1981-11-01
EP0049928A2 (en) 1982-04-21
DE3176811D1 (en) 1988-08-25
AU548333B2 (en) 1985-12-05
PT73807B (fr) 1983-01-17
EP0049928A3 (en) 1983-04-06
KR880000691B1 (ko) 1988-04-23
FR2491927A1 (fr) 1982-04-16
ATE35813T1 (de) 1988-08-15
YU246381A (en) 1983-10-31
IT1195762B (it) 1988-10-27
US4471115A (en) 1984-09-11
AR229035A1 (es) 1983-05-31

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