IT1195762B - Derivati idrosolubili della cefalexina e procedimento per la loro produzione - Google Patents

Derivati idrosolubili della cefalexina e procedimento per la loro produzione

Info

Publication number
IT1195762B
IT1195762B IT25267/80A IT2526780A IT1195762B IT 1195762 B IT1195762 B IT 1195762B IT 25267/80 A IT25267/80 A IT 25267/80A IT 2526780 A IT2526780 A IT 2526780A IT 1195762 B IT1195762 B IT 1195762B
Authority
IT
Italy
Prior art keywords
cephalexin
procedure
production
water soluble
soluble derivatives
Prior art date
Application number
IT25267/80A
Other languages
English (en)
Other versions
IT8025267A0 (it
Inventor
Alberto Reiner
Original Assignee
Reiner Alberto Real Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reiner Alberto Real Sas filed Critical Reiner Alberto Real Sas
Publication of IT8025267A0 publication Critical patent/IT8025267A0/it
Priority to IT25267/80A priority Critical patent/IT1195762B/it
Priority to JP56057257A priority patent/JPS5767583A/ja
Priority to DE8181201107T priority patent/DE3176811D1/de
Priority to EP81201107A priority patent/EP0049928B1/en
Priority to AT81201107T priority patent/ATE35813T1/de
Priority to AU76247/81A priority patent/AU548333B2/en
Priority to NO813433A priority patent/NO813433L/no
Priority to DK451281A priority patent/DK451281A/da
Priority to PT73807A priority patent/PT73807B/pt
Priority to FR8119156A priority patent/FR2491927B1/fr
Priority to ES506213A priority patent/ES8206533A1/es
Priority to CA000387814A priority patent/CA1181741A/en
Priority to BE0/206233A priority patent/BE890718A/fr
Priority to AR287074A priority patent/AR229035A1/es
Priority to KR1019810003864A priority patent/KR880000691B1/ko
Priority to YU02463/81A priority patent/YU246381A/xx
Priority to US06/452,159 priority patent/US4471115A/en
Application granted granted Critical
Publication of IT1195762B publication Critical patent/IT1195762B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT25267/80A 1980-10-13 1980-10-13 Derivati idrosolubili della cefalexina e procedimento per la loro produzione IT1195762B (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IT25267/80A IT1195762B (it) 1980-10-13 1980-10-13 Derivati idrosolubili della cefalexina e procedimento per la loro produzione
JP56057257A JPS5767583A (en) 1980-10-13 1981-04-17 Water-soluble derivative of cephalexin and manufacture
DE8181201107T DE3176811D1 (en) 1980-10-13 1981-10-06 Water soluble derivatives of cephalexin and process for their preparation
EP81201107A EP0049928B1 (en) 1980-10-13 1981-10-06 Water soluble derivatives of cephalexin and process for their preparation
AT81201107T ATE35813T1 (de) 1980-10-13 1981-10-06 Wasserloesliche cephalexinderivate und verfahren zu ihrer herstellung.
PT73807A PT73807B (fr) 1980-10-13 1981-10-12 Procede de preparation de derives de cephalexine solubles dans l'eau
NO813433A NO813433L (no) 1980-10-13 1981-10-12 Vannopploeselige derivater av cefalexin og fremstilling derav
DK451281A DK451281A (da) 1980-10-13 1981-10-12 Fremgangsmaade til fremstilling af cephalexin-derivater
AU76247/81A AU548333B2 (en) 1980-10-13 1981-10-12 Cephalexin derivatives
FR8119156A FR2491927B1 (fr) 1980-10-13 1981-10-12 Derives de cephalexine solubles dans l'eau, et procede pour leur preparation
BE0/206233A BE890718A (fr) 1980-10-13 1981-10-13 Derives de cephalexine solubles dans l'eau, et procede pour leur preparation.
CA000387814A CA1181741A (en) 1980-10-13 1981-10-13 Water soluble derivatives of cephalexin and process for their preparation
ES506213A ES8206533A1 (es) 1980-10-13 1981-10-13 Procedimiento para preparar derivados metilolados de cefale-xina
AR287074A AR229035A1 (es) 1980-10-13 1981-10-13 Metodo para la preparacion de un derivado 2-n-metilol de cefalexina
KR1019810003864A KR880000691B1 (ko) 1980-10-13 1981-10-13 세팔렉신의 수용성 유도체의 제조 방법
YU02463/81A YU246381A (en) 1980-10-13 1981-10-13 Process for obtaining cephalexine derivatives
US06/452,159 US4471115A (en) 1980-10-13 1982-12-22 Water soluble derivatives of cephalex and process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT25267/80A IT1195762B (it) 1980-10-13 1980-10-13 Derivati idrosolubili della cefalexina e procedimento per la loro produzione

Publications (2)

Publication Number Publication Date
IT8025267A0 IT8025267A0 (it) 1980-10-13
IT1195762B true IT1195762B (it) 1988-10-27

Family

ID=11216176

Family Applications (1)

Application Number Title Priority Date Filing Date
IT25267/80A IT1195762B (it) 1980-10-13 1980-10-13 Derivati idrosolubili della cefalexina e procedimento per la loro produzione

Country Status (17)

Country Link
US (1) US4471115A (it)
EP (1) EP0049928B1 (it)
JP (1) JPS5767583A (it)
KR (1) KR880000691B1 (it)
AR (1) AR229035A1 (it)
AT (1) ATE35813T1 (it)
AU (1) AU548333B2 (it)
BE (1) BE890718A (it)
CA (1) CA1181741A (it)
DE (1) DE3176811D1 (it)
DK (1) DK451281A (it)
ES (1) ES8206533A1 (it)
FR (1) FR2491927B1 (it)
IT (1) IT1195762B (it)
NO (1) NO813433L (it)
PT (1) PT73807B (it)
YU (1) YU246381A (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202007544RA (en) * 2018-02-28 2020-09-29 Bridge Biotherapeutics Inc Water soluble salts of lipidated peptides and methods for preparing and using the same
US11419913B2 (en) * 2018-03-29 2022-08-23 S.I.S Shulov Innovative Science Ltd. Pharmaceutical compositions for inhibiting inflammatory cytokines
KR102104507B1 (ko) * 2019-08-23 2020-04-24 브릿지바이오테라퓨틱스(주) 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1265315A (it) * 1968-04-05 1972-03-01 Glaxo Lab Ltd
BE786924A (fr) * 1971-07-28 1973-01-29 Squibb & Sons Inc Antibiotiques, leur preparation et leurs utilisations therapeutiques
US3796709A (en) * 1971-11-19 1974-03-12 Squibb & Sons Inc (alpha-cyanamino)acetamidocephalosporins
BE792229A (fr) * 1971-12-03 1973-06-01 Bristol Myers Co Agents antibacteriens heterocycliques azotes et procede pour les preparer
US3880842A (en) * 1972-05-30 1975-04-29 Squibb & Sons Inc Cephalosporin derivatives
US3988326A (en) * 1974-02-22 1976-10-26 Meiji Seika Kaisha, Ltd. Process for N-acylation of 7 amino cephem compounds

Also Published As

Publication number Publication date
JPS5767583A (en) 1982-04-24
AU7624781A (en) 1982-04-22
BE890718A (fr) 1982-02-01
AR229035A1 (es) 1983-05-31
CA1181741A (en) 1985-01-29
ATE35813T1 (de) 1988-08-15
AU548333B2 (en) 1985-12-05
EP0049928A3 (en) 1983-04-06
PT73807A (fr) 1981-11-01
DK451281A (da) 1982-04-14
FR2491927A1 (fr) 1982-04-16
NO813433L (no) 1982-04-14
ES506213A0 (es) 1982-08-16
EP0049928A2 (en) 1982-04-21
US4471115A (en) 1984-09-11
KR830007681A (ko) 1983-11-04
FR2491927B1 (fr) 1985-07-12
EP0049928B1 (en) 1988-07-20
ES8206533A1 (es) 1982-08-16
DE3176811D1 (en) 1988-08-25
KR880000691B1 (ko) 1988-04-23
PT73807B (fr) 1983-01-17
IT8025267A0 (it) 1980-10-13
YU246381A (en) 1983-10-31

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