SG11202007544RA - Water soluble salts of lipidated peptides and methods for preparing and using the same - Google Patents

Water soluble salts of lipidated peptides and methods for preparing and using the same

Info

Publication number
SG11202007544RA
SG11202007544RA SG11202007544RA SG11202007544RA SG11202007544RA SG 11202007544R A SG11202007544R A SG 11202007544RA SG 11202007544R A SG11202007544R A SG 11202007544RA SG 11202007544R A SG11202007544R A SG 11202007544RA SG 11202007544R A SG11202007544R A SG 11202007544RA
Authority
SG
Singapore
Prior art keywords
preparing
methods
same
water soluble
soluble salts
Prior art date
Application number
SG11202007544RA
Inventor
Sang Uk Kang
Original Assignee
Bridge Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bridge Biotherapeutics Inc filed Critical Bridge Biotherapeutics Inc
Publication of SG11202007544RA publication Critical patent/SG11202007544RA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891Coated capsules; Multilayered drug free capsule shells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1024Tetrapeptides with the first amino acid being heterocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846Poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/485Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5026Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Immunology (AREA)
SG11202007544RA 2018-02-28 2019-02-27 Water soluble salts of lipidated peptides and methods for preparing and using the same SG11202007544RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862636552P 2018-02-28 2018-02-28
PCT/KR2019/002397 WO2019168357A1 (en) 2018-02-28 2019-02-27 Water soluble salts of lipidated peptides and methods for preparing and using the same

Publications (1)

Publication Number Publication Date
SG11202007544RA true SG11202007544RA (en) 2020-09-29

Family

ID=67684306

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202007544RA SG11202007544RA (en) 2018-02-28 2019-02-27 Water soluble salts of lipidated peptides and methods for preparing and using the same

Country Status (9)

Country Link
US (1) US11739120B2 (en)
EP (1) EP3759070A4 (en)
JP (2) JP7104141B2 (en)
KR (1) KR102058853B1 (en)
CN (1) CN110959002A (en)
PH (1) PH12020551233A1 (en)
SG (1) SG11202007544RA (en)
TW (2) TWI811767B (en)
WO (1) WO2019168357A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102104507B1 (en) * 2019-08-23 2020-04-24 브릿지바이오테라퓨틱스(주) Pharmaceutical formulations comprising sodium palmitoyl-l-prolyl-l-prolyl-glycyl-l-tyrosinate and methods for preparing the same
CN111297905B (en) * 2020-03-18 2022-11-04 四川大学华西医院 Skin precursor cell-based extract and preparation method and application thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1195762B (en) * 1980-10-13 1988-10-27 Reiner Alberto Real Sas WATER SOLUBLE DERIVATIVES OF CEPHALEXIN AND PROCEDURE FOR THEIR PRODUCTION
DE3839127A1 (en) 1988-11-19 1990-05-23 Hoechst Ag PYRROLIDONE-2-CARBONIC ACID DERIVATIVES WITH PSYCHOTROPER EFFECT
AUPM906594A0 (en) 1994-10-26 1994-11-17 Peptide Technology Limited Synthetic polyunsaturated fatty acid analogues
PT923555E (en) 1996-05-01 2005-09-30 Ortho Mcneil Pharm Inc DERIVATIVES CARBOXAMIDE OF PYRROLIDINE, PIPERIDINE AND HEXA-HYDROAZEPINE FOR THE TREATMENT OF TROMBOTIC DISTURBLES
DE69915004T2 (en) 1998-11-05 2004-09-09 Pfizer Products Inc., Groton 5-Oxo-pyrrolidine-2-carboxylic acid Hydroxamidderivate
WO2003007876A2 (en) 2001-06-25 2003-01-30 University Of Massachusetts N-fatty acid-amino acid conjugates and therapeutic uses
US20060252698A1 (en) 2005-04-20 2006-11-09 Malcolm Bruce A Compounds for inhibiting cathepsin activity
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
MX2010002300A (en) * 2007-08-29 2010-03-18 Pfizer Prod Inc Polymorphs of 3- ( ( (4-tert-butyl-benzyl) - (pyridine-3-sulfonyl ) -amino) -methyl) -phenoxy) -acetic acid sodium salt or a hydrate thereof and methods for making the same.
WO2010059922A1 (en) * 2008-11-21 2010-05-27 Ligand Pharmaceuticals Incorporated Pyrrolidine carboxamide compounds
KR101151878B1 (en) 2010-06-08 2012-05-31 미원상사주식회사 Fatty Acid Tripeptide Salt and Antimicrobial Composition Containing the Same
KR101348284B1 (en) 2010-09-09 2014-01-03 주식회사 나이벡 Combination of Human derived Cell Permeable Peptide and Bioactive Peptide (TOPscovery) and Use Thereof
KR20120048864A (en) 2010-11-08 2012-05-16 주식회사 네오디엠 A method for preparing the preventive and therapeutic compositions for atopic dermatitis
KR20130038426A (en) 2011-10-07 2013-04-18 성균관대학교산학협력단 Glycol chitosan hydrogel modified hydrophobically with fatty acid-bonded antidiabetic peptide and a pharmaceutical composition for prevention or treatment of diabetes comprising the same
KR101359886B1 (en) 2011-12-28 2014-02-12 성균관대학교산학협력단 Composition for treating sepsis or septic shock comprising the Peptide originated from the Smad6
US20150368197A1 (en) * 2012-06-21 2015-12-24 Radikal Therapeutics Ins. Compositions and methods for treatment of inflammatory diseases of the lung
CN103724204B (en) * 2013-11-27 2016-05-11 北京化工大学 A kind of water soluble starter and preparation
PT3265443T (en) * 2015-07-08 2020-02-14 Korea Res Inst Chemical Tech Pyrrolidine carboxamido derivatives and methods for preparing and using the same

Also Published As

Publication number Publication date
JP2020529435A (en) 2020-10-08
EP3759070A4 (en) 2021-12-08
CN110959002A (en) 2020-04-03
WO2019168357A1 (en) 2019-09-06
KR102058853B1 (en) 2019-12-24
JP2022106788A (en) 2022-07-20
TW202222818A (en) 2022-06-16
TWI811767B (en) 2023-08-11
EP3759070A1 (en) 2021-01-06
TWI762770B (en) 2022-05-01
JP7104141B2 (en) 2022-07-20
US20190263859A1 (en) 2019-08-29
TW201936577A (en) 2019-09-16
KR20190103986A (en) 2019-09-05
US11739120B2 (en) 2023-08-29
PH12020551233A1 (en) 2021-05-17

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