IT1167504B - Derivati della 7-ossoprostaciclina e procedimento per la loro preparazione - Google Patents

Derivati della 7-ossoprostaciclina e procedimento per la loro preparazione

Info

Publication number
IT1167504B
IT1167504B IT24030/81A IT2403081A IT1167504B IT 1167504 B IT1167504 B IT 1167504B IT 24030/81 A IT24030/81 A IT 24030/81A IT 2403081 A IT2403081 A IT 2403081A IT 1167504 B IT1167504 B IT 1167504B
Authority
IT
Italy
Prior art keywords
oxoprostacycline
derivatives
procedure
preparation
Prior art date
Application number
IT24030/81A
Other languages
English (en)
Other versions
IT8124030A0 (it
Inventor
Robert C Nickolson
Helmut Vorbruggen
Jorge Casals-Stenzel
Gerda Mannesmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IT8124030A0 publication Critical patent/IT8124030A0/it
Application granted granted Critical
Publication of IT1167504B publication Critical patent/IT1167504B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/07Preparation of halogenated hydrocarbons by addition of hydrogen halides
    • C07C17/08Preparation of halogenated hydrocarbons by addition of hydrogen halides to unsaturated hydrocarbons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03Monocarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13Dicarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015Esters of acyclic unsaturated acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/535Organo-phosphoranes
    • C07F9/5352Phosphoranes containing the structure P=C-

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT24030/81A 1980-09-18 1981-09-18 Derivati della 7-ossoprostaciclina e procedimento per la loro preparazione IT1167504B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803035454 DE3035454A1 (de) 1980-09-18 1980-09-18 7-oxoprostacyclinderivate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
IT8124030A0 IT8124030A0 (it) 1981-09-18
IT1167504B true IT1167504B (it) 1987-05-13

Family

ID=6112413

Family Applications (1)

Application Number Title Priority Date Filing Date
IT24030/81A IT1167504B (it) 1980-09-18 1981-09-18 Derivati della 7-ossoprostaciclina e procedimento per la loro preparazione

Country Status (17)

Country Link
US (1) US4466969A (it)
EP (1) EP0059756B1 (it)
JP (1) JPH0314031B2 (it)
AU (1) AU557398B2 (it)
BE (1) BE890390A (it)
CA (1) CA1220470A (it)
CS (1) CS226440B2 (it)
DE (2) DE3035454A1 (it)
DK (1) DK220982A (it)
ES (1) ES8205787A1 (it)
FI (1) FI66367C (it)
GR (1) GR75350B (it)
HU (1) HU200601B (it)
IE (1) IE51792B1 (it)
IT (1) IT1167504B (it)
WO (1) WO1982001002A1 (it)
ZA (1) ZA816516B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3340988A1 (de) * 1983-11-10 1985-05-23 Schering AG, 1000 Berlin und 4709 Bergkamen 20-alkyl-7-oxoprostacyclinderivate und verfahren zu ihrer herstellung
US5190973A (en) * 1983-11-10 1993-03-02 Schering Aktiengesellschaft 20-alkyl-7-oxoprostacyclin derivatives useful as pharmaceuticals
HU191264B (en) * 1984-01-13 1987-01-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for production of derivatives of 7-oxo-prostacyclin with selective biological effect
HU197733B (en) * 1985-05-29 1989-05-29 Chinoin Gyogyszer Es Vegyeszet Process for producing ephedrin-salts of 7-oxo-prosta-cyclin derivatives
DE3610556A1 (de) * 1986-03-26 1987-10-01 Schering Ag 7-oxoprostacyclinderivate und verfahren zu ihrer herstellung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4330553A (en) * 1979-11-12 1982-05-18 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 7-Oxo-PGI2 -derivatives and process for the preparation thereof and pharmaceutical compositions containing same
HU182012B (en) * 1979-11-12 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 6-substituted-7-oxo-pgi down 1 derivatives

Also Published As

Publication number Publication date
ZA816516B (en) 1982-09-29
JPH0314031B2 (it) 1991-02-25
GR75350B (it) 1984-07-13
FI821707A0 (fi) 1982-05-14
CA1220470A (en) 1987-04-14
IE812163L (en) 1982-03-18
IT8124030A0 (it) 1981-09-18
ES505576A0 (es) 1982-08-16
EP0059756B1 (en) 1985-08-28
DE3035454A1 (de) 1982-04-22
JPS57501482A (it) 1982-08-19
ES8205787A1 (es) 1982-08-16
AU557398B2 (en) 1986-12-18
FI821707A (fi) 1982-05-14
FI66367C (fi) 1984-10-10
AU7809181A (en) 1982-04-14
BE890390A (fr) 1982-03-17
IE51792B1 (en) 1987-04-01
DK220982A (da) 1982-05-17
WO1982001002A1 (en) 1982-04-01
CS226440B2 (en) 1984-03-19
FI66367B (fi) 1984-06-29
HU200601B (en) 1990-07-28
DE3172032D1 (en) 1985-10-03
US4466969A (en) 1984-08-21
EP0059756A1 (en) 1982-09-15

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