ES8205787A1 - Procedimiento para la preparacion de derivados de 7-oxopros-taciclina - Google Patents

Procedimiento para la preparacion de derivados de 7-oxopros-taciclina

Info

Publication number
ES8205787A1
ES8205787A1 ES505576A ES505576A ES8205787A1 ES 8205787 A1 ES8205787 A1 ES 8205787A1 ES 505576 A ES505576 A ES 505576A ES 505576 A ES505576 A ES 505576A ES 8205787 A1 ES8205787 A1 ES 8205787A1
Authority
ES
Spain
Prior art keywords
optionally substituted
straight
chain
pct
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505576A
Other languages
English (en)
Other versions
ES505576A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES8205787A1 publication Critical patent/ES8205787A1/es
Publication of ES505576A0 publication Critical patent/ES505576A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/07—Preparation of halogenated hydrocarbons by addition of hydrogen halides
    • C07C17/08—Preparation of halogenated hydrocarbons by addition of hydrogen halides to unsaturated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/535—Organo-phosphoranes
    • C07F9/5352—Phosphoranes containing the structure P=C-

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE -OXOPROSTACICLINA, ASI COMO DE SUS SALES CON BASES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R5 ES UN GRUPO HIDROXI QUE PUEDE ESTAR ESRERIFICADO; R1, R2, A, D Y E PUEDEN SER VARIOS TIPOS DE RADICALES, Y D Y E PUEDEN SIGNIFICAR JUNTOS UN ENLACE DIRECTO. CONSISTE EN LA REACCION DE OXIDACION DE UN COMPUESTO DE FORMULA (II) CON DIOXIDO DE SELENIO, FORMULA EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO, TAL COMO DIOXANO O T-BUTANOL,BAL ATMOSFERA INERTE,EN PRESENCIA DE UNA BASE AMINICA Y A UNA TEMPERATURA ENTRE 20 Y 140 C.
ES505576A 1980-09-18 1981-09-17 Procedimiento para la preparacion de derivados de 7-oxopros-taciclina Granted ES505576A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803035454 DE3035454A1 (de) 1980-09-18 1980-09-18 7-oxoprostacyclinderivate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8205787A1 true ES8205787A1 (es) 1982-08-16
ES505576A0 ES505576A0 (es) 1982-08-16

Family

ID=6112413

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505576A Granted ES505576A0 (es) 1980-09-18 1981-09-17 Procedimiento para la preparacion de derivados de 7-oxopros-taciclina

Country Status (17)

Country Link
US (1) US4466969A (es)
EP (1) EP0059756B1 (es)
JP (1) JPH0314031B2 (es)
AU (1) AU557398B2 (es)
BE (1) BE890390A (es)
CA (1) CA1220470A (es)
CS (1) CS226440B2 (es)
DE (2) DE3035454A1 (es)
DK (1) DK220982A (es)
ES (1) ES505576A0 (es)
FI (1) FI66367C (es)
GR (1) GR75350B (es)
HU (1) HU200601B (es)
IE (1) IE51792B1 (es)
IT (1) IT1167504B (es)
WO (1) WO1982001002A1 (es)
ZA (1) ZA816516B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3340988A1 (de) * 1983-11-10 1985-05-23 Schering AG, 1000 Berlin und 4709 Bergkamen 20-alkyl-7-oxoprostacyclinderivate und verfahren zu ihrer herstellung
US5190973A (en) * 1983-11-10 1993-03-02 Schering Aktiengesellschaft 20-alkyl-7-oxoprostacyclin derivatives useful as pharmaceuticals
HU191264B (en) * 1984-01-13 1987-01-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for production of derivatives of 7-oxo-prostacyclin with selective biological effect
HU197733B (en) * 1985-05-29 1989-05-29 Chinoin Gyogyszer Es Vegyeszet Process for producing ephedrin-salts of 7-oxo-prosta-cyclin derivatives
DE3610556A1 (de) * 1986-03-26 1987-10-01 Schering Ag 7-oxoprostacyclinderivate und verfahren zu ihrer herstellung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU182012B (en) * 1979-11-12 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 6-substituted-7-oxo-pgi down 1 derivatives
US4330553A (en) * 1979-11-12 1982-05-18 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 7-Oxo-PGI2 -derivatives and process for the preparation thereof and pharmaceutical compositions containing same

Also Published As

Publication number Publication date
DE3172032D1 (en) 1985-10-03
BE890390A (fr) 1982-03-17
IE812163L (en) 1982-03-18
FI66367C (fi) 1984-10-10
IT8124030A0 (it) 1981-09-18
FI821707A (fi) 1982-05-14
ZA816516B (en) 1982-09-29
EP0059756B1 (en) 1985-08-28
IT1167504B (it) 1987-05-13
IE51792B1 (en) 1987-04-01
FI821707A0 (fi) 1982-05-14
GR75350B (es) 1984-07-13
JPS57501482A (es) 1982-08-19
AU7809181A (en) 1982-04-14
CA1220470A (en) 1987-04-14
ES505576A0 (es) 1982-08-16
HU200601B (en) 1990-07-28
CS226440B2 (en) 1984-03-19
FI66367B (fi) 1984-06-29
WO1982001002A1 (en) 1982-04-01
EP0059756A1 (en) 1982-09-15
AU557398B2 (en) 1986-12-18
US4466969A (en) 1984-08-21
JPH0314031B2 (es) 1991-02-25
DE3035454A1 (de) 1982-04-22
DK220982A (da) 1982-05-17

Similar Documents

Publication Publication Date Title
DE3169305D1 (en) Carbacyclins, process for their preparation and their utilization as pharmaceutical preparations
ES2004543A6 (es) Procedimiento para la preparacion de clatratos con ciclodextrinas de derivados de carbaciclina
DE3268528D1 (en) Derivatives of 9-fluoroprostaglandin, process for their preparation and their use as medicaments
ES444478A1 (es) Mejoras introducidas en un procedimiento para eliminar el oxigeno disuelto en el agua.
KR830005092A (ko) 시클로프로판 카르복실산의 새로운 유도체
GB1186505A (en) Improvements in or relating to the preparation of Cyclopentane Derivatives
ES8205787A1 (es) Procedimiento para la preparacion de derivados de 7-oxopros-taciclina
AU559925B2 (en) Carbocyclic prostacyclin alcohol analogs
IL68715A0 (en) Carbacyclin esters,process for their manufacture and pharmaceutical compositions containing the same
KR850000026A (ko) 바이 사이클로(3.2.1)-옥탄 카르복실산의 제조방법 및 조성물
JPS6434965A (en) Novel aconitine based compound and analgesic and antiphlogistic agent containing said compound as active ingredient
ES2060150T3 (es) Nuevos derivados de leucotrieno-b4, procedimiento para su preparacion y su utilizacion como medicamentos.
DE3481707D1 (de) 7-alpha-substituierte 3-oxo-17alpha-pregn-4-en-21.17-carbolactone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
JPS5246067A (en) Reduction of optically active 5-oxo-2-pyrrolidinacetic acid esters
ES395036A2 (es) Procedimiento para producir un compuesto opticamente acti- vo.
GB948117A (en) Preparation of o, o-dimethyl dithiophosphoryl-acetic acidmonomethyl amide
GB1270120A (en) Pyrimidine carboxylic acid ester derivatives
BE887426A (fr) Derives de prostacycline, leur procede de preparation et leur utilisation
GB1397807A (en) Process for preparing alpha-keto esters
ES446837A1 (es) Procedimiento para la preparacion de sales de ester dimeti- laminoetilico de acido para-clorofenoxiacetico.
JPS5297943A (en) Prostaglandin derivatives
GB957432A (en) Manufacture of 21-hydroxy-pregnanes and new í¸-18:20-oxido-pregnanes
GB1444889A (en) Process for the preparation of succinylosuccinic acid diesters
GB1227547A (es)
FR2378009A2 (fr) Nouveaux analogues de prostaglandines, leur procede de preparation et leurs applications therapeutiques