KR830004258A - 옥소화합물과 이에 필요한 새로운 중간체의 제조방법 - Google Patents

옥소화합물과 이에 필요한 새로운 중간체의 제조방법 Download PDF

Info

Publication number
KR830004258A
KR830004258A KR1019800004136A KR800004136A KR830004258A KR 830004258 A KR830004258 A KR 830004258A KR 1019800004136 A KR1019800004136 A KR 1019800004136A KR 800004136 A KR800004136 A KR 800004136A KR 830004258 A KR830004258 A KR 830004258A
Authority
KR
South Korea
Prior art keywords
methods
dibenz
azepine
new intermediates
preparing new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019800004136A
Other languages
English (en)
Other versions
KR850000945B1 (ko
Inventor
아프델하아르 에론스트
Original Assignee
아놀드 자일러, 에론스트 알테르
시바-가이기 에이지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아놀드 자일러, 에론스트 알테르, 시바-가이기 에이지 filed Critical 아놀드 자일러, 에론스트 알테르
Publication of KR830004258A publication Critical patent/KR830004258A/ko
Priority to KR1019850000412A priority Critical patent/KR850000944B1/ko
Application granted granted Critical
Publication of KR850000945B1 publication Critical patent/KR850000945B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음

Description

옥소화합물과 이에 필요한 새로운 중간체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 도식으로 대표되는 다음 일반식(Ⅰ)의 5-시아노-5H-디벤즈[b, f] 아제핀을 니트로화시키고 결과로 생긴 다음 일반식(Ⅱ)의 5-시아노-10-니트로-5H-디벤즈[b, f] 아제핀을 가수분해시켜서 다음 일반식(Ⅳ)의 5-카바모일-10-니트로-5H-디벤즈[b, f] 아제핀을 형성하고 이 화합물중 10-니트로 그룹을 환원시키고 환원생성물을 가수분해시킴을 특징으로하여 다음 일반식(Ⅲ)의 5-카바모일-10-옥소-10,11-디하이드로-5H-디벤즈[b, f] 아제핀을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800004136A 1979-10-30 1980-10-29 5-카바모일-10-옥소-10, 11-디하이드로-5H-디벤즈[b, f]-아제핀의 제조방법 Expired KR850000945B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019850000412A KR850000944B1 (ko) 1979-10-30 1985-01-23 5-카바모일-10-옥소-10, 11-디하이드로-5H-디벤즈[b,f]아제핀

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH970379 1979-10-30
CH9703 1979-10-30
CH9703/79-2 1979-10-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019850000412A Division KR850000944B1 (ko) 1979-10-30 1985-01-23 5-카바모일-10-옥소-10, 11-디하이드로-5H-디벤즈[b,f]아제핀

Publications (2)

Publication Number Publication Date
KR830004258A true KR830004258A (ko) 1983-07-09
KR850000945B1 KR850000945B1 (ko) 1985-06-29

Family

ID=4354732

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800004136A Expired KR850000945B1 (ko) 1979-10-30 1980-10-29 5-카바모일-10-옥소-10, 11-디하이드로-5H-디벤즈[b, f]-아제핀의 제조방법

Country Status (28)

Country Link
US (4) US4452738A (ko)
EP (1) EP0028028B1 (ko)
JP (5) JPS5673067A (ko)
KR (1) KR850000945B1 (ko)
AT (1) ATE13426T1 (ko)
AU (1) AU538069B2 (ko)
CA (1) CA1163993A (ko)
CY (1) CY1418A (ko)
DD (1) DD153835A5 (ko)
DE (1) DE3070675D1 (ko)
DK (5) DK163302C (ko)
ES (1) ES496333A0 (ko)
FI (1) FI75561C (ko)
GR (1) GR71889B (ko)
HK (1) HK50388A (ko)
HU (1) HU181208B (ko)
IE (1) IE50723B1 (ko)
IL (1) IL61360A (ko)
KE (1) KE3791A (ko)
LU (1) LU88347I2 (ko)
NL (1) NL930105I2 (ko)
NO (1) NO154725C (ko)
NZ (1) NZ195395A (ko)
PL (1) PL227523A1 (ko)
PT (1) PT71992B (ko)
SG (1) SG103787G (ko)
YU (5) YU44318B (ko)
ZA (1) ZA806643B (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE80141T1 (de) * 1987-04-27 1992-09-15 Takeda Chemical Industries Ltd Reduktion von carbonsaeureestern.
US5472714A (en) * 1993-09-08 1995-12-05 Ciba-Geigy Corporation Double-layered oxcarbazepine tablets
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
PT101876B (pt) * 1996-05-27 1999-09-30 Portela & Ca Sa Novos derivados de 10,11-di-hidro-10-oxo-5h-dibenzo(b,f)azepina-5-carboxamida
CO4920215A1 (es) * 1997-02-14 2000-05-29 Novartis Ag Tabletas de oxacarbazepina recubiertas de una pelicula y metodo para la produccion de estas formulaciones
US20020022056A1 (en) 1997-02-14 2002-02-21 Burkhard Schlutermann Oxacarbazepine film-coated tablets
AT408224B (de) * 1999-03-15 2001-09-25 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von oxcarbazepin
IT1317854B1 (it) * 2000-02-25 2003-07-15 Farchemia Srl 5-ciano-10-idrossi-10,11-diidro-5h-dibenz(b,f)azepina e procedimentiper la sua preparazione e per la sua conversione in
CA2437402A1 (en) * 2001-02-12 2002-08-22 Teva Pharmaceutical Industries, Ltd. New crystal forms of oxcarbazepine and processes for their preparation
CA2471666C (en) 2004-06-18 2009-10-13 Apotex Pharmachem Inc. An improved process for the preparation of oxcarbazepine and related intermediates
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
EP2026815B1 (en) * 2006-04-26 2011-01-26 Supernus Pharmaceuticals, Inc. Controlled released preparations of oxcarbazepine having sigmoidal release profile
CA2658675A1 (en) * 2006-07-24 2008-01-31 Jubilant Organosys Limited Process for producing 10-oxo-10, 11-dihydr0-5h-dibenz [b, f] azepine-5-carboxamide starting from 5-cyanoiminostilbene
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
AU2008302125B2 (en) * 2007-09-19 2012-01-12 Ravenbrick, Llc Low-emissivity window films and coatings incoporating nanoscale wire grids
CN100591672C (zh) * 2008-07-04 2010-02-24 浙江工业大学 一种奥卡西平的化学合成方法
US20150065704A1 (en) 2011-07-13 2015-03-05 Ketan Hirpara Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
WO2014049550A1 (en) 2012-09-26 2014-04-03 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
CN103288736B (zh) * 2013-02-05 2015-08-05 南京华威医药科技开发有限公司 一种艾司利卡西平中间体的制备方法
EP3459365B8 (en) 2017-09-22 2025-10-22 Unilever IP Holdings B.V. Composition comprising vegetable oil and apple cider vinegar

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2762796A (en) * 1956-09-11 Iminodibenzyl derivative
BE597793A (fr) * 1960-12-05 1961-06-05 Geigy Ag J R Nouveaux dérivés de l'azépine et leur préparation.
US3420834A (en) * 1964-11-13 1969-01-07 Roussel Uclaf 2,3-dimethoxy-berbines substituted in the 10 position and process
FR1532301A (fr) * 1967-01-18 1968-07-12 Rhone Poulenc Sa Nouveaux dérivés de la dibenzazépine et leur préparation
CH500196A (de) * 1969-03-10 1970-12-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Azepinderivaten
NL144275B (nl) * 1969-06-24 1974-12-16 Rhone Poulenc Sa Werkwijze voor de bereiding van fungicide preparaten.
US3637661A (en) * 1970-03-04 1972-01-25 Ciba Geigy Corp 10-hydroxy-10 11-dihydro-dibenzazepine derivative
US4235895A (en) * 1978-11-10 1980-11-25 Ciba-Geigy Corporation Substituted 5H-dibenz[b,f]azepine
JPS5681565A (en) * 1979-10-30 1981-07-03 Ciba Geigy Ag Manufacture of nnheterocyclic compound

Also Published As

Publication number Publication date
NO154725B (no) 1986-09-01
LU88347I2 (fr) 1994-05-04
NL930105I1 (nl) 1993-10-18
DK163302C (da) 1992-07-06
JPS6445366A (en) 1989-02-17
DK99191A (da) 1991-05-24
IE802237L (en) 1981-04-30
JPH0240660B2 (ko) 1990-09-12
NZ195395A (en) 1982-09-14
YU45521B (en) 1992-05-28
HK50388A (en) 1988-07-15
YU45519B (en) 1992-05-28
IL61360A0 (en) 1980-12-31
DK99291D0 (da) 1991-05-24
PT71992A (en) 1980-11-01
US4540514A (en) 1985-09-10
DK99291A (da) 1991-05-24
DK163302B (da) 1992-02-17
YU136689A (en) 1990-02-28
CY1418A (en) 1988-04-22
DK99391D0 (da) 1991-05-24
IE50723B1 (en) 1986-06-25
DD153835A5 (de) 1982-02-03
DK99391A (da) 1991-05-24
JPS6445367A (en) 1989-02-17
JPS6445370A (en) 1989-02-17
AU6380580A (en) 1981-05-07
YU136489A (en) 1990-02-28
CA1163993A (en) 1984-03-20
FI75561B (fi) 1988-03-31
EP0028028A2 (de) 1981-05-06
NL930105I2 (nl) 1995-02-16
JPS5673067A (en) 1981-06-17
YU45520B (en) 1992-05-28
DK99091A (da) 1991-05-24
SG103787G (en) 1988-09-30
FI803078A7 (fi) 1981-05-01
DK99191D0 (da) 1991-05-24
JPH0314025B2 (ko) 1991-02-25
ES8300708A1 (es) 1982-11-01
NO803228L (no) 1981-05-04
EP0028028B1 (de) 1985-05-22
US4559174A (en) 1985-12-17
YU136589A (en) 1990-02-28
EP0028028A3 (en) 1981-08-26
HU181208B (en) 1983-06-28
ZA806643B (en) 1981-10-28
YU45522B (en) 1992-05-28
PL227523A1 (ko) 1981-06-19
PT71992B (en) 1981-08-31
AU538069B2 (en) 1984-07-26
YU277880A (en) 1983-12-31
US4452738A (en) 1984-06-05
KR850000945B1 (ko) 1985-06-29
JPH0114225B2 (ko) 1989-03-10
IL61360A (en) 1984-04-30
DK457780A (da) 1981-05-01
YU44318B (en) 1990-06-30
ATE13426T1 (de) 1985-06-15
JPH0240661B2 (ko) 1990-09-12
GR71889B (ko) 1983-08-05
FI75561C (fi) 1988-07-11
DE3070675D1 (en) 1985-06-27
YU137289A (en) 1990-02-21
ES496333A0 (es) 1982-11-01
NO154725C (no) 1986-12-10
DK99091D0 (da) 1991-05-24
DK170335B1 (da) 1995-08-07
JPS6445368A (en) 1989-02-17
JPH0240662B2 (ko) 1990-09-12
US4579683A (en) 1986-04-01
KE3791A (en) 1988-03-31

Similar Documents

Publication Publication Date Title
KR830004258A (ko) 옥소화합물과 이에 필요한 새로운 중간체의 제조방법
FR2361353A1 (fr) Derives de cyclohexane utiles comme cristaux liquides
KR880011111A (ko) 치환된 9-아미노-테트라하이드로아크리딘 및 그의 관련화합물, 그들의 제조방법 및 약제로서의 그들의 용도
KR850008657A (ko) 포름산의 제조방법
KR830003531A (ko) 섬유 형성 코폴리에스테르
KR840004737A (ko) 6a,10a-트랜스-헥사하이드로디벤조피라논의 제조방법
KR850004754A (ko) 3-인돌 카르복사미드 화합물류의 제조방법
KR840001152A (ko) 신규 복소환(複素環) 화합물의 제법
KR850002460A (ko) 카르바메이트 화합물의 제조방법
KR830004320A (ko) 퀴나졸린 유도체의 제조방법
KR840003606A (ko) 판테놀 유도체의 제제 판테놀 유도체의 제제방법
KR850005830A (ko) 2-알콕시아미노설포닐벤젠-설포닐우레아의 제조방법
KR840004053A (ko) 페닐알카노산의 제조방법
KR840002821A (ko) N-(2,3-에폭시프로필렌)-n-아르알킬술폰아미드 유도체의 제조방법
KR880000411A (ko) 벤조구아나민 유도체의 제법
KR850007247A (ko) 바이페닐릴설포닐 우레아의 제조방법
KR860004066A (ko) 피페라실린(Piperacilline)의 제조방법
KR970001338A (ko) 크라운 에테르형 시클로판 화합물 및 그의 제조 방법
KR850004471A (ko) 유기 화합물의 제조방법
KR860004008A (ko) 부타놀유도체의 제법
KR890002176A (ko) 신규한 세펨 화합물
KR890002178A (ko) 신규한 세펨 화합물
KR920007967A (ko) 케탈의 연속 제조방법
KR840002367A (ko) 3-메틸-3-(4-아세틸아미노펜옥시)-2,4-디옥사벤조-사이클로헥사논-1-의 제조방법
KR860002972A (ko) 동물 사료 첨가제

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19950630

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19950630