KR830003423A - 디하이드로 니코틴산 유도체의 제제방법 - Google Patents
디하이드로 니코틴산 유도체의 제제방법 Download PDFInfo
- Publication number
- KR830003423A KR830003423A KR1019800002785A KR800002785A KR830003423A KR 830003423 A KR830003423 A KR 830003423A KR 1019800002785 A KR1019800002785 A KR 1019800002785A KR 800002785 A KR800002785 A KR 800002785A KR 830003423 A KR830003423 A KR 830003423A
- Authority
- KR
- South Korea
- Prior art keywords
- nicotinic acid
- preparation
- acid derivative
- acid
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/08—Preparation by ring-closure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 다음 구조식(II)의 상응하는 1,4,5,6-테트라하이드로 니코틴산 또는 이들의 에스테르를 5,6-위치에서 탈수소화 하고 필요한 경우, 수득된 산을 알칼리금속, 알칼리토금속 또는 (임의로 치환된) 암모늄염으로 전환시키거나, 수득된 산을 C1-6-알칸올로 에스테르화 하거나 또는 수득된 메틸에스테르를 검화하여 다음 구조식(I)의 1-에틸-1,4-디하이드로-6-(2-나프틸)-4-옥소 니코틴산과 이들의 에스테르 및 알칼리금속, 알칼리토금속 및 (임의로 치환된) 암모늄염을 제조하는 방법.상기 구조식에서 R은 수소 또는 C1-3알킬이다.* 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH6555 | 1979-07-13 | ||
CH655579 | 1979-07-13 | ||
CH6555/79 | 1979-07-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830003423A true KR830003423A (ko) | 1983-06-20 |
KR840001034B1 KR840001034B1 (ko) | 1984-07-26 |
Family
ID=4311435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019800002785A KR840001034B1 (ko) | 1979-07-13 | 1980-07-12 | 디하이드로니코틴산 유도체의 제조방법 |
Country Status (21)
Country | Link |
---|---|
US (1) | US4278798A (ko) |
EP (1) | EP0023593B1 (ko) |
JP (1) | JPS5615269A (ko) |
KR (1) | KR840001034B1 (ko) |
AR (1) | AR225447A1 (ko) |
AT (1) | ATE2520T1 (ko) |
AU (1) | AU537900B2 (ko) |
CA (1) | CA1125762A (ko) |
DE (1) | DE3062022D1 (ko) |
DK (1) | DK148082B (ko) |
ES (1) | ES8105712A1 (ko) |
FI (1) | FI802097A (ko) |
GR (1) | GR69304B (ko) |
HU (1) | HU180589B (ko) |
IL (1) | IL60513A (ko) |
MC (1) | MC1335A1 (ko) |
NO (1) | NO802099L (ko) |
NZ (1) | NZ194258A (ko) |
PH (1) | PH16046A (ko) |
PT (1) | PT71542B (ko) |
ZA (1) | ZA804079B (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1110234A (en) * | 1978-01-18 | 1981-10-06 | Hoffmann-La Roche Limited | 4-pyridone-3-carboxylic acids and process for the preparation thereof |
US4649157A (en) * | 1986-03-28 | 1987-03-10 | G. D. Searle & Co. | Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds |
US9988373B2 (en) | 2013-12-26 | 2018-06-05 | Shionogi & Co., Ltd. | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4051142A (en) * | 1976-05-24 | 1977-09-27 | Rohm And Haas Company | 1-Aryl-4-pyridones |
EP0001041A3 (en) * | 1977-07-27 | 1979-06-27 | Sandoz Ag | Alpha(pyridonecarboxylamino)-alpha substituted acetamido penicillins and -cephalosporins, process for their preparation, their use in pharmaceuticals; pyridones used in the process |
CA1110234A (en) * | 1978-01-18 | 1981-10-06 | Hoffmann-La Roche Limited | 4-pyridone-3-carboxylic acids and process for the preparation thereof |
-
1980
- 1980-06-09 CA CA353,626A patent/CA1125762A/en not_active Expired
- 1980-06-11 MC MC801452A patent/MC1335A1/xx unknown
- 1980-07-01 FI FI802097A patent/FI802097A/fi not_active Application Discontinuation
- 1980-07-02 DK DK287080AA patent/DK148082B/da unknown
- 1980-07-07 US US06/166,506 patent/US4278798A/en not_active Expired - Lifetime
- 1980-07-07 AU AU60153/80A patent/AU537900B2/en not_active Ceased
- 1980-07-07 NZ NZ194258A patent/NZ194258A/en unknown
- 1980-07-07 IL IL60513A patent/IL60513A/xx unknown
- 1980-07-07 HU HU80801689A patent/HU180589B/hu unknown
- 1980-07-07 AR AR281682A patent/AR225447A1/es active
- 1980-07-07 ZA ZA00804079A patent/ZA804079B/xx unknown
- 1980-07-08 EP EP80103895A patent/EP0023593B1/de not_active Expired
- 1980-07-08 AT AT80103895T patent/ATE2520T1/de not_active IP Right Cessation
- 1980-07-08 DE DE8080103895T patent/DE3062022D1/de not_active Expired
- 1980-07-09 PH PH24260A patent/PH16046A/en unknown
- 1980-07-11 GR GR62435A patent/GR69304B/el unknown
- 1980-07-11 JP JP9410780A patent/JPS5615269A/ja active Pending
- 1980-07-11 NO NO802099A patent/NO802099L/no unknown
- 1980-07-11 PT PT71542A patent/PT71542B/pt unknown
- 1980-07-12 KR KR1019800002785A patent/KR840001034B1/ko active
- 1980-07-12 ES ES493355A patent/ES8105712A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DK287080A (da) | 1981-01-14 |
AU537900B2 (en) | 1984-07-19 |
EP0023593B1 (de) | 1983-02-16 |
CA1125762A (en) | 1982-06-15 |
US4278798A (en) | 1981-07-14 |
NO802099L (no) | 1981-01-14 |
ZA804079B (en) | 1981-07-29 |
ES493355A0 (es) | 1981-06-16 |
HU180589B (en) | 1983-03-28 |
ATE2520T1 (de) | 1983-03-15 |
JPS5615269A (en) | 1981-02-14 |
FI802097A (fi) | 1981-01-14 |
IL60513A (en) | 1983-10-31 |
DK148082B (da) | 1985-02-25 |
PH16046A (en) | 1983-06-02 |
GR69304B (ko) | 1982-05-14 |
NZ194258A (en) | 1984-07-06 |
KR840001034B1 (ko) | 1984-07-26 |
PT71542A (en) | 1980-08-01 |
DE3062022D1 (en) | 1983-03-24 |
MC1335A1 (fr) | 1981-04-21 |
EP0023593A1 (de) | 1981-02-11 |
AU6015380A (en) | 1981-01-15 |
ES8105712A1 (es) | 1981-06-16 |
IL60513A0 (en) | 1980-09-16 |
AR225447A1 (es) | 1982-03-31 |
PT71542B (en) | 1981-12-14 |
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