KR20260035294A - 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산 - Google Patents

인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산

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Publication number
KR20260035294A
KR20260035294A KR1020267005115A KR20267005115A KR20260035294A KR 20260035294 A KR20260035294 A KR 20260035294A KR 1020267005115 A KR1020267005115 A KR 1020267005115A KR 20267005115 A KR20267005115 A KR 20267005115A KR 20260035294 A KR20260035294 A KR 20260035294A
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virus
nucleic acid
cell
microbial
human
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Pending
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Korean (ko)
Inventor
이위즌 드 블라민크
마이클 케르테스츠
키란 케이. 쿠쉬
마크 알렉 코와르스키
랜스 마틴
스티븐 알. 퀘이크
한나 발란틴
Original Assignee
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티
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Application filed by 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티, 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 filed Critical 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티
Publication of KR20260035294A publication Critical patent/KR20260035294A/ko
Pending legal-status Critical Current

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    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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    • G16B30/10Sequence alignment; Homology search
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  • Virology (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
KR1020267005115A 2013-11-07 2014-11-07 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산 Pending KR20260035294A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361901114P 2013-11-07 2013-11-07
US61/901,114 2013-11-07
US201361901857P 2013-11-08 2013-11-08
US61/901,857 2013-11-08
PCT/US2014/064669 WO2015070086A1 (en) 2013-11-07 2014-11-07 Cell-free nucleic acids for the analysis of the human microbiome and components thereof
KR1020247008723A KR102930443B1 (ko) 2013-11-07 2014-11-07 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산

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KR1020247008723A Division KR102930443B1 (ko) 2013-11-07 2014-11-07 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산

Publications (1)

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KR20260035294A true KR20260035294A (ko) 2026-03-12

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KR1020267005115A Pending KR20260035294A (ko) 2013-11-07 2014-11-07 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산
KR1020167013334A Active KR102205950B1 (ko) 2013-11-07 2014-11-07 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산
KR1020217001442A Active KR102649364B1 (ko) 2013-11-07 2014-11-07 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산
KR1020247008723A Active KR102930443B1 (ko) 2013-11-07 2014-11-07 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산

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KR1020167013334A Active KR102205950B1 (ko) 2013-11-07 2014-11-07 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산
KR1020217001442A Active KR102649364B1 (ko) 2013-11-07 2014-11-07 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산
KR1020247008723A Active KR102930443B1 (ko) 2013-11-07 2014-11-07 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산

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US (6) US10450620B2 (https=)
EP (2) EP4130350A1 (https=)
JP (4) JP7451070B2 (https=)
KR (4) KR20260035294A (https=)
CN (2) CN112877472A (https=)
AU (1) AU2014346562B2 (https=)
BR (1) BR112016010095A2 (https=)
CA (2) CA3207499A1 (https=)
GB (1) GB2535382A (https=)
IL (4) IL285106B (https=)
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WO (1) WO2015070086A1 (https=)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
RU2671980C2 (ru) 2011-02-09 2018-11-08 Натера, Инк. Способы неинвазивного пренатального установления плоидности
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
AU2014346562B2 (en) 2013-11-07 2018-11-29 The Board Of Trustees Of The Leland Stanford Junior University Cell-free nucleic acids for the analysis of the human microbiome and components thereof
WO2017062863A1 (en) 2015-10-09 2017-04-13 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US10767222B2 (en) 2013-12-11 2020-09-08 Accuragen Holdings Limited Compositions and methods for detecting rare sequence variants
US11859246B2 (en) * 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
CA2945962C (en) 2014-04-21 2023-08-29 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
US10410749B2 (en) 2014-10-21 2019-09-10 uBiome, Inc. Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions
WO2016065075A1 (en) 2014-10-21 2016-04-28 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics
US10325685B2 (en) 2014-10-21 2019-06-18 uBiome, Inc. Method and system for characterizing diet-related conditions
WO2016100955A2 (en) 2014-12-20 2016-06-23 Identifygenomics, Llc Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using crispr/cas system proteins
CN106103742B (zh) * 2015-01-06 2019-12-10 深圳市海普洛斯生物科技有限公司 一种富集循环肿瘤dna的方法和试剂
US10893509B2 (en) 2015-02-11 2021-01-12 Qualcomm Incorporated Multiple tri-state HARQ processes
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
JP6873921B2 (ja) 2015-05-18 2021-05-19 カリウス・インコーポレイテッド 核酸の集団を濃縮するための組成物および方法
US10415105B2 (en) 2015-06-30 2019-09-17 uBiome, Inc. Method and system for diagnostic testing
US10538758B2 (en) 2015-08-19 2020-01-21 Arc Bio, Llc Capture of nucleic acids using a nucleic acid-guided nuclease-based system
AU2016321349B2 (en) * 2015-09-09 2023-06-08 Macrogen Inc. Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with gastrointestinal health
WO2017044902A1 (en) * 2015-09-09 2017-03-16 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for oral health
EP3141612A1 (en) * 2015-09-10 2017-03-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method and device for nucleic acid based diagnostic approaches including the determination of a deviant condtion, especially a health condition and/or pathogenic condition of a sample
EP3146974A1 (en) * 2015-09-25 2017-03-29 Universite Claude Bernard - Lyon 1 Biomarkers for early determination of severity of influenza related disease
WO2017096322A1 (en) 2015-12-03 2017-06-08 Accuragen Holdings Limited Methods and compositions for forming ligation products
CN105603076A (zh) * 2016-01-29 2016-05-25 江汉大学 一种土壤微生物定性与定量的检测方法
CN105671150A (zh) * 2016-01-29 2016-06-15 江汉大学 一种人体微生物定性与定量的检测方法
CN105603074B (zh) * 2016-01-29 2019-11-15 江汉大学 一种非诊断目的微生物定性与定量的检测方法
CN105603075A (zh) * 2016-01-29 2016-05-25 江汉大学 一种小麦微生物定性与定量的检测方法
CN105567831B (zh) * 2016-01-29 2019-07-23 江汉大学 一种食品微生物定性与定量的检测方法
EP3978627A1 (en) 2016-03-25 2022-04-06 Karius, Inc. Methods using synthetic nucleic acid spike-ins
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
CA3022294A1 (en) * 2016-04-25 2017-11-02 uBiome, Inc. Method and system for characterizing skin-related conditions
CN109511265B (zh) 2016-05-16 2023-07-14 安可济控股有限公司 通过链鉴定改进测序的方法
FR3051482B1 (fr) 2016-05-19 2021-01-29 Life & Soft Procede de determination de la presence et quantification d'au moins un micro-organisme dans un echantillon biologique
US10144962B2 (en) * 2016-06-30 2018-12-04 Grail, Inc. Differential tagging of RNA for preparation of a cell-free DNA/RNA sequencing library
CN109844133A (zh) 2016-08-15 2019-06-04 安可济控股有限公司 检测罕见序列变体的组合物和方法
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
IL307463B2 (en) * 2016-11-17 2026-01-01 Lgc Clinical Diagnostics Inc Methods for preparing DNA reference material and controls
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
US20210115506A1 (en) * 2017-04-04 2021-04-22 The Board Of Trustees Of The Leland Stanford Junior University Quantification of transplant-derived circulating cell-free DNA in the absence of a donor genotype
WO2018187521A2 (en) * 2017-04-06 2018-10-11 Cornell University Methods of detecting cell-free dna in biological samples
WO2018191563A1 (en) 2017-04-12 2018-10-18 Karius, Inc. Sample preparation methods, systems and compositions
EP3431610A1 (en) 2017-07-19 2019-01-23 Noscendo GmbH Methods and devices for nucleic acid-based real-time determination of disease states
CN111094583A (zh) 2017-08-04 2020-05-01 十亿至一公司 与生物靶相关的定量中利用靶相关分子的测序输出确定和分析
US11519024B2 (en) 2017-08-04 2022-12-06 Billiontoone, Inc. Homologous genomic regions for characterization associated with biological targets
WO2019028462A1 (en) 2017-08-04 2019-02-07 Billiontoone, Inc. TARGET-ASSOCIATED MOLECULES FOR CHARACTERIZATION ASSOCIATED WITH BIOLOGICAL TARGETS
WO2019060716A1 (en) 2017-09-25 2019-03-28 Freenome Holdings, Inc. SAMPLE EXTRACTION METHODS AND SYSTEMS
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
EP4650456A3 (en) 2018-01-05 2026-01-21 BillionToOne, Inc. Quality control templates for ensuring validity of sequencing-based assays
US12398389B2 (en) 2018-02-15 2025-08-26 Natera, Inc. Methods for isolating nucleic acids with size selection
JP2021518106A (ja) * 2018-03-13 2021-08-02 ガーダント ヘルス, インコーポレイテッド 治療用核酸構築物の非侵襲的な検出およびモニタリングのための方法
CA3082601A1 (en) 2018-03-16 2019-09-19 Karius, Inc. Sample series to differentiate target nucleic acids from contaminant nucleic acids
EP3785269A4 (en) * 2018-03-29 2021-12-29 Freenome Holdings, Inc. Methods and systems for analyzing microbiota
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
CN108660199A (zh) * 2018-05-20 2018-10-16 北京宏微特斯生物科技有限公司 一种基于cfDNA高通量测序检测病原体的方法
WO2019241290A1 (en) 2018-06-12 2019-12-19 Accuragen Holdings Limited Methods and compositions for forming ligation products
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
EP3833776A4 (en) * 2018-08-06 2022-04-27 Billiontoone, Inc. DILUTION MARKER FOR QUANTIFICATION OF BIOLOGICAL TARGETS
KR102114758B1 (ko) * 2018-11-19 2020-05-26 경북대학교 산학협력단 멤브레인 구조물을 이용한 혈액 내 미생물의 핵산 추출을 위한 혈액 시료 전처리 방법
EP4700161A3 (en) 2018-11-21 2026-03-11 Karius, Inc. Direct-to-library methods, systems, and compositions
AU2019403269A1 (en) 2018-12-18 2021-06-17 Grail, Llc Methods for detecting disease using analysis of RNA
WO2020198664A1 (en) * 2019-03-28 2020-10-01 The Regents Of The University Of California Methods and systems for sequencing cell-free microbiome dna
KR20220015367A (ko) 2019-05-31 2022-02-08 프리놈 홀딩스, 인크. 메틸화된 핵산의 고심도 시퀀싱 방법 및 시스템
KR102503766B1 (ko) * 2020-06-16 2023-02-23 씨제이바이오사이언스 주식회사 장내 마이크로바이옴 지수를 결정하기 위한 장치, 방법 및 명령을 기록한 기록 매체
WO2022103975A1 (en) * 2020-11-12 2022-05-19 Micronoma, Inc. Systems and methods to improve therapeutic outcomes
US20220195496A1 (en) * 2020-12-17 2022-06-23 Karius, Inc. Sequencing microbial cell-free dna from asymptomatic individuals
WO2022140302A1 (en) * 2020-12-21 2022-06-30 Karius, Inc. Sequencing microbial cell-free nucleic acids to detect inflammation, secondary infection, and disease severity
CN113061666A (zh) * 2020-12-30 2021-07-02 中南大学湘雅二医院 肝移植后巨细胞病毒的检测方法、应用及系统
WO2022197864A1 (en) * 2021-03-18 2022-09-22 Natera, Inc. Methods for determination of transplant rejection
AU2022325908A1 (en) * 2021-08-11 2024-01-04 Immunosis Pty Ltd Methods for determining secondary immunodeficiency
WO2023141347A2 (en) * 2022-01-24 2023-07-27 Gusto Global, Llc Single-loci and multi-loci targeted single point amplicon fragment sequencing
KR20250019610A (ko) 2022-03-21 2025-02-10 빌리언투원, 인크. 치료 모니터링을 위한 메틸화된 세포 유리 dna의 분자 계수
WO2025024111A1 (en) * 2023-07-25 2025-01-30 Gusto Global, Llc Single point amplicon fragment sequencing and methods for diagnosing and monitoring disease
WO2025087333A1 (en) * 2023-10-24 2025-05-01 Centre For Novostics Analysis of microbial dna for disease classification
US20250191691A1 (en) * 2023-12-07 2025-06-12 California Institute Of Technology Methods for the translated alignment of transcriptomic data at single-cell resolution
WO2025175229A1 (en) * 2024-02-16 2025-08-21 Karius, Inc. Multi-step methods for detecting nucleic acids
WO2025231437A1 (en) * 2024-05-03 2025-11-06 Karius, Inc. Predicting cytokine release syndrome in car-t cell therapy

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242794A (en) 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US6287850B1 (en) 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
USRE39920E1 (en) 1997-05-30 2007-11-13 Xenomics, Inc. Methods for detection of nucleic acid sequences in urine
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US20030022207A1 (en) 1998-10-16 2003-01-30 Solexa, Ltd. Arrayed polynucleotides and their use in genome analysis
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
AU7537200A (en) 1999-09-29 2001-04-30 Solexa Ltd. Polynucleotide sequencing
US6582938B1 (en) 2001-05-11 2003-06-24 Affymetrix, Inc. Amplification of nucleic acids
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
US6897023B2 (en) 2000-09-27 2005-05-24 The Molecular Sciences Institute, Inc. Method for determining relative abundance of nucleic acid sequences
US6753137B2 (en) 2001-01-31 2004-06-22 The Chinese University Of Hong Kong Circulating epstein-barr virus DNA in the serum of patients with gastric carcinoma
US6996477B2 (en) * 2001-04-19 2006-02-07 Dana Farber Cancer Institute, Inc. Computational subtraction method
DE10120797B4 (de) 2001-04-27 2005-12-22 Genovoxx Gmbh Verfahren zur Analyse von Nukleinsäureketten
AU2002337030A1 (en) 2001-08-29 2003-03-18 Genovoxx Gmbh Method for analyzing nucleic acid sequences and gene expression
JP2003101204A (ja) 2001-09-25 2003-04-04 Nec Kansai Ltd 配線基板及び配線基板の製造方法並びに電子部品
DE10246005A1 (de) 2001-10-04 2003-04-30 Genovoxx Gmbh Gerät zur Sequenzierung von Nukleinsäuremolekülen
DE10149786B4 (de) 2001-10-09 2013-04-25 Dmitry Cherkasov Oberfläche für Untersuchungen aus Populationen von Einzelmolekülen
US20050124022A1 (en) 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US20050202414A1 (en) 2001-11-15 2005-09-15 The Regents Of The University Of California Apparatus and methods for detecting a microbe in a sample
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
IL163600A0 (en) 2002-03-01 2005-12-18 Ravgen Inc Methods for detection of genetic disorders
DE10214395A1 (de) 2002-03-30 2003-10-23 Dmitri Tcherkassov Verfahren zur Analyse von Einzelnukleotidpolymorphismen
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
CN1688719A (zh) * 2002-07-01 2005-10-26 瓦罗洛吉克公司 确定致病性病毒对蛋白酶抑制剂易感性的组合物和方法
CA2513899C (en) 2003-01-29 2013-03-26 454 Corporation Methods of amplifying and sequencing nucleic acids
US20040209299A1 (en) 2003-03-07 2004-10-21 Rubicon Genomics, Inc. In vitro DNA immortalization and whole genome amplification using libraries generated from randomly fragmented DNA
EP1617805A4 (en) 2003-04-11 2012-07-04 Medimmune Llc METHODS FOR PREVENTING OR TREATING RESPIRATORY CONDITIONS
DE10356837A1 (de) 2003-12-05 2005-06-30 Dmitry Cherkasov Modifizierte Nukleotide und Nukleoside
EP1725572B1 (de) 2003-11-05 2017-05-31 AGCT GmbH Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
JP2007515414A (ja) 2003-12-16 2007-06-14 パレンテラル アー エス 血漿置換剤およびその製造方法
DE102004009704A1 (de) 2004-02-27 2005-09-15 Dmitry Cherkasov Makromolekulare Nukleotidverbindungen und Methoden zu deren Anwendung
DE102004025694A1 (de) 2004-05-26 2006-02-23 Dmitry Cherkasov Verfahren und Oberfläche zu hochparallelen Analysen von Nukleinsäureketten
DE102004025695A1 (de) 2004-05-26 2006-02-23 Dmitry Cherkasov Verfahren und Oberfläche zur parallelen Sequenzierung von Nukleinsäureketten
DE102004025696A1 (de) 2004-05-26 2006-02-23 Dmitry Cherkasov Verfahren, Oberfläche und Substrate zu hochparallelen Analysen von Nukleinsäureketten
DE102004025744A1 (de) 2004-05-26 2005-12-29 Dmitry Cherkasov Oberfläche für die Analysen an einzelnen Nukleinsäuremolekülen
DE102004025746A1 (de) 2004-05-26 2005-12-15 Dmitry Cherkasov Verfahren, Oberfläche und Substrate zur hochparallelen Sequenzierung von Nukleinsäureketten
DE102004025745A1 (de) 2004-05-26 2005-12-15 Cherkasov, Dmitry Oberfläche für die Analysen an einzelnen Molekülen
US20060002471A1 (en) 2004-06-30 2006-01-05 Lippincott Louis A Motion estimation unit
US20060012793A1 (en) 2004-07-19 2006-01-19 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US7276720B2 (en) 2004-07-19 2007-10-02 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US20060024678A1 (en) 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
WO2006089203A2 (en) 2005-02-17 2006-08-24 Istituto Nazionale Per Le Malattie Infettive Irccs Lazzaro Spallanzani Compositions and methods for detecting viral specific nucleic acids in urine
EP2351857B1 (en) 2005-02-17 2014-10-29 TrovaGene, Inc. Compositions and methods for detecting pathogen specific nucleic acids in urine
ITRM20050068A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
US7914982B2 (en) 2005-02-17 2011-03-29 Trovagene, Inc. Methods for detecting pathogen specific nucleic acids in urine
ITRM20050067A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine.
US8532930B2 (en) 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
IES20090464A2 (en) * 2008-06-13 2010-03-03 Nat Univ Ireland SWI5 gene as a diagnostic target for the identification of fungal and yeast species
EP2853601B1 (en) 2008-07-18 2016-09-21 TrovaGene, Inc. Methods for PCR-based detection of "ultra short" nucleic acid sequences
WO2011015944A2 (en) 2009-08-06 2011-02-10 Cedars-Sinai Medical Center Use of free dna as an early predictor of severity in acute pancreatitis
JP2013509883A (ja) 2009-11-06 2013-03-21 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 臓器移植患者における移植片拒絶反応の非侵襲的診断方法
EP2325312A1 (de) 2009-11-19 2011-05-25 Qiagen GmbH Verfahren zur selektiven Anreicherung und Isolierung mikrobieller und optional zusätzlich viraler Nukleinsäuren
CN102071261A (zh) * 2009-11-24 2011-05-25 上海复星医学科技发展有限公司 一种单纯疱疹病毒核酸检测方法及试剂盒
EP3098236A1 (en) 2010-03-08 2016-11-30 Celltrion, Inc. Human monoclonal antibodies derived from human b cells and having neutralizing activity against influenza a viruses
US20120077185A1 (en) 2010-08-06 2012-03-29 Tandem Diagnostics, Inc. Detection of genetic abnormalities and infectious disease
EP2694680A4 (en) 2011-04-01 2014-09-10 Occam Biolabs Inc METHOD AND KITS FOR DETECTION OF CELL-FREE NURVIVAL-SPECIFIC NUCLEIC ACIDS
WO2012159023A2 (en) * 2011-05-19 2012-11-22 Virginia Commonwealth University Gut microflora as biomarkers for the prognosis of cirrhosis and brain dysfunction
EP2718862B1 (en) 2011-06-06 2018-10-31 Koninklijke Philips N.V. Method for assembly of nucleic acid sequence data
US20130024127A1 (en) 2011-07-19 2013-01-24 John Stuelpnagel Determination of source contributions using binomial probability calculations
WO2013052907A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
HK1211624A1 (en) 2012-01-27 2016-05-27 The Board Of Trustees Of The University Of The Leland Stanford Junior University Methods for profiling and quantitating cell-free rna
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
CA2866324C (en) 2012-03-13 2019-01-15 The Chinese University Of Hong Kong Methods for analyzing massively parallel sequencing data for noninvasive prenatal diagnosis
EP3741871A3 (en) * 2012-04-19 2021-02-17 The Medical College of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free dna
EP2653562A1 (en) * 2012-04-20 2013-10-23 Institut Pasteur Anellovirus genome quantification as a biomarker of immune suppression
JP2015522260A (ja) 2012-06-15 2015-08-06 ハリー スティリ, 疾患または状態を検出する方法
CN104781421B (zh) 2012-09-04 2020-06-05 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP2728014B1 (en) 2012-10-31 2015-10-07 Genesupport SA Non-invasive method for detecting a fetal chromosomal aneuploidy
US20140242582A1 (en) 2013-02-28 2014-08-28 Ariosa Diagnostics, Inc. Detection of genetic abnormalities using ligation-based detection and digital pcr
WO2014145078A1 (en) 2013-03-15 2014-09-18 Verinata Health, Inc. Generating cell-free dna libraries directly from blood
CN114574581A (zh) 2013-03-15 2022-06-03 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
AU2014346562B2 (en) 2013-11-07 2018-11-29 The Board Of Trustees Of The Leland Stanford Junior University Cell-free nucleic acids for the analysis of the human microbiome and components thereof
WO2015085105A1 (en) 2013-12-04 2015-06-11 University Of Alaska Fairbanks Methods and compositions for enriching non-host sequences in host samples
US10450650B2 (en) 2015-09-24 2019-10-22 The United States of America as represented by the Admininstrator of the National Aeronautics and Space Administration Method of manufacturing large area graphene and graphene-based photonics devices
JP7577928B2 (ja) 2019-06-19 2024-11-06 株式会社リコー トナー及び現像剤

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