KR20250070142A - 이온 채널 조절인자 - Google Patents

이온 채널 조절인자 Download PDF

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Publication number
KR20250070142A
KR20250070142A KR1020257015904A KR20257015904A KR20250070142A KR 20250070142 A KR20250070142 A KR 20250070142A KR 1020257015904 A KR1020257015904 A KR 1020257015904A KR 20257015904 A KR20257015904 A KR 20257015904A KR 20250070142 A KR20250070142 A KR 20250070142A
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South Korea
Prior art keywords
mmol
mixture
give
methyl
etoac
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Pending
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KR1020257015904A
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English (en)
Korean (ko)
Inventor
앤드류 마크 그리핀
브리안 에드워드 마론
가브리엘 마르티네즈 보텔라
키란 레디
마리온 위트만
Original Assignee
프락시스 프리시젼 메디신즈, 인크.
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Publication of KR20250070142A publication Critical patent/KR20250070142A/ko
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020257015904A 2018-05-30 2019-05-30 이온 채널 조절인자 Pending KR20250070142A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862677903P 2018-05-30 2018-05-30
US62/677,903 2018-05-30
US201862738508P 2018-09-28 2018-09-28
US62/738,508 2018-09-28
KR1020207037964A KR102809796B1 (ko) 2018-05-30 2019-05-30 이온 채널 조절인자
PCT/US2019/034653 WO2019232209A1 (en) 2018-05-30 2019-05-30 Ion channel modulators

Related Parent Applications (1)

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KR1020207037964A Division KR102809796B1 (ko) 2018-05-30 2019-05-30 이온 채널 조절인자

Publications (1)

Publication Number Publication Date
KR20250070142A true KR20250070142A (ko) 2025-05-20

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Family Applications (2)

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KR1020257015904A Pending KR20250070142A (ko) 2018-05-30 2019-05-30 이온 채널 조절인자
KR1020207037964A Active KR102809796B1 (ko) 2018-05-30 2019-05-30 이온 채널 조절인자

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US (6) US11866439B2 (https=)
EP (2) EP3801535A4 (https=)
JP (4) JP7359847B2 (https=)
KR (2) KR20250070142A (https=)
CN (4) CN112423760A (https=)
AU (2) AU2019278814B2 (https=)
BR (1) BR112020024379A2 (https=)
CA (1) CA3101324A1 (https=)
IL (3) IL309843B1 (https=)
MX (3) MX2020012838A (https=)
SG (1) SG11202011879RA (https=)
TW (2) TW202436298A (https=)
WO (1) WO2019232209A1 (https=)

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IL279064B1 (en) 2026-01-01
US20240132501A1 (en) 2024-04-25
EP4487916A2 (en) 2025-01-08
AU2025271306A1 (en) 2025-12-18
CN119371426A (zh) 2025-01-28
KR20210024500A (ko) 2021-03-05
US11731978B2 (en) 2023-08-22
US12325711B2 (en) 2025-06-10
JP2023144130A (ja) 2023-10-06
AU2019278814B2 (en) 2025-12-18
CN112423760A (zh) 2021-02-26
JP2024071530A (ja) 2024-05-24
IL279064A (en) 2021-01-31
US20220220118A1 (en) 2022-07-14
IL309843B1 (en) 2026-01-01
EP3801535A1 (en) 2021-04-14
EP3801535A4 (en) 2022-03-02
CN117756800A (zh) 2024-03-26
MX2020012838A (es) 2021-07-16
US20210087197A1 (en) 2021-03-25
CN119350320A (zh) 2025-01-24
JP7738930B2 (ja) 2025-09-16
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US20250376475A1 (en) 2025-12-11
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US11014931B2 (en) 2021-05-25
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US20210163488A1 (en) 2021-06-03
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