KR20240029115A - 개선된 ｔｎｆ 결합제 - Google Patents

개선된 ｔｎｆ 결합제 Download PDF

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Publication number
KR20240029115A
KR20240029115A KR1020247005963A KR20247005963A KR20240029115A KR 20240029115 A KR20240029115 A KR 20240029115A KR 1020247005963 A KR1020247005963 A KR 1020247005963A KR 20247005963 A KR20247005963 A KR 20247005963A KR 20240029115 A KR20240029115 A KR 20240029115A
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KR
South Korea
Prior art keywords
ser
gly
isvd
amino acid
val
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Pending
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KR1020247005963A
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English (en)
Korean (ko)
Inventor
마리에 앙게 부이세
요아힘 보우스뉴
페테르 카스틸스
헤케 지노 반
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아블린쓰 엔.브이.
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Publication of KR20240029115A publication Critical patent/KR20240029115A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Insulating Materials (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
KR1020247005963A 2015-11-12 2016-11-14 개선된 ｔｎｆ 결합제 Pending KR20240029115A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562254375P 2015-11-12 2015-11-12
US62/254,375 2015-11-12
PCT/EP2016/077595 WO2017081320A1 (en) 2015-11-12 2016-11-14 Improved tnf binders
KR1020187016731A KR102641194B1 (ko) 2015-11-12 2016-11-14 개선된 ｔｎｆ 결합제

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187016731A Division KR102641194B1 (ko) 2015-11-12 2016-11-14 개선된 ｔｎｆ 결합제

Publications (1)

Publication Number Publication Date
KR20240029115A true KR20240029115A (ko) 2024-03-05

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020247005963A Pending KR20240029115A (ko) 2015-11-12 2016-11-14 개선된 ｔｎｆ 결합제
KR1020187016731A Active KR102641194B1 (ko) 2015-11-12 2016-11-14 개선된 ｔｎｆ 결합제

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EP (2) EP3191511B1 (cg-RX-API-DMAC7.html)
JP (2) JP6962915B2 (cg-RX-API-DMAC7.html)
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WO2022129572A1 (en) 2020-12-18 2022-06-23 Ablynx Nv Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-alpha
CN116615453A (zh) * 2020-12-18 2023-08-18 埃博灵克斯股份有限公司 包含靶向IL-6和TNF-α的免疫球蛋白单可变结构域的多肽
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Publication number Publication date
CL2018001291A1 (es) 2018-09-14
IL259269A (en) 2018-07-31
IL310373A (en) 2024-03-01
NO2768984T3 (cg-RX-API-DMAC7.html) 2018-06-09
RS56676B1 (sr) 2018-03-30
MD3191511T2 (ro) 2018-03-31
RU2018120524A3 (cg-RX-API-DMAC7.html) 2020-09-24
IL259269B1 (en) 2024-03-01
JP7357038B2 (ja) 2023-10-05
MX2018005992A (es) 2019-01-31
US10544211B2 (en) 2020-01-28
CA3234178A1 (en) 2017-05-18
DOP2018000122A (es) 2018-09-30
BR112018009714A2 (en) 2018-11-21
KR102641194B1 (ko) 2024-02-26
BR112018009714A8 (pt) 2019-02-26
PH12018501025A1 (en) 2019-01-28
WO2017081320A1 (en) 2017-05-18
ECSP18042569A (es) 2018-07-31
SMT201700590T1 (it) 2018-01-11
EP3266798A3 (en) 2018-03-28
KR20180083382A (ko) 2018-07-20
CN108473563A (zh) 2018-08-31
IL259269B2 (en) 2024-07-01
HUE035805T2 (en) 2018-05-28
LT3191511T (lt) 2018-01-10
TN2018000159A1 (en) 2019-10-04
EP3266798A2 (en) 2018-01-10
MX385207B (es) 2025-03-04
SI3191511T1 (en) 2018-01-31
HK1248716A1 (en) 2018-10-19
AU2023200113A1 (en) 2023-02-16
AU2016352943A1 (en) 2018-06-07
CN108473563B (zh) 2022-06-14
EP3191511A1 (en) 2017-07-19
PT3191511T (pt) 2017-11-30
JP2022020666A (ja) 2022-02-01
PE20181317A1 (es) 2018-08-14
ME02954B (me) 2018-07-20
HRP20171949T1 (hr) 2018-01-26
US20170190769A1 (en) 2017-07-06
EP3191511B1 (en) 2017-09-20
JP6962915B2 (ja) 2021-11-10
CR20180311A (es) 2018-10-18
DK3191511T3 (en) 2018-01-08
GT201800095A (es) 2019-08-15
RU2018120524A (ru) 2019-12-13
CO2018005915A2 (es) 2018-06-20
PL3191511T3 (pl) 2018-03-30
CA3005085C (en) 2024-09-10
CA3005085A1 (en) 2017-05-18
SG11201803975SA (en) 2018-06-28
US9745372B2 (en) 2017-08-29
AU2016352943B2 (en) 2022-10-20
JP2019506839A (ja) 2019-03-14
ES2662418T3 (es) 2018-04-06
MA41653A (fr) 2018-01-09
CY1120303T1 (el) 2019-07-10
US20170267752A1 (en) 2017-09-21

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