MA41653A - Liants de tnf améliorés - Google Patents

Liants de tnf améliorés

Info

Publication number
MA41653A
MA41653A MA041653A MA41653A MA41653A MA 41653 A MA41653 A MA 41653A MA 041653 A MA041653 A MA 041653A MA 41653 A MA41653 A MA 41653A MA 41653 A MA41653 A MA 41653A
Authority
MA
Morocco
Prior art keywords
enhanced tnf
tnf binders
binders
enhanced
tnf
Prior art date
Application number
MA041653A
Other languages
English (en)
Inventor
Joachim Boucneau
Marie-Ange Buyse
Peter Casteels
Heeke Gino Van
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ablynx Nv filed Critical Ablynx Nv
Publication of MA41653A publication Critical patent/MA41653A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Insulating Materials (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
MA041653A 2015-11-12 2016-11-13 Liants de tnf améliorés MA41653A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562254375P 2015-11-12 2015-11-12

Publications (1)

Publication Number Publication Date
MA41653A true MA41653A (fr) 2018-01-09

Family

ID=57348648

Family Applications (1)

Application Number Title Priority Date Filing Date
MA041653A MA41653A (fr) 2015-11-12 2016-11-13 Liants de tnf améliorés

Country Status (36)

Country Link
US (2) US10544211B2 (fr)
EP (2) EP3266798A3 (fr)
JP (2) JP6962915B2 (fr)
KR (2) KR20240029115A (fr)
CN (1) CN108473563B (fr)
AU (2) AU2016352943B2 (fr)
BR (1) BR112018009714A8 (fr)
CA (2) CA3005085A1 (fr)
CL (1) CL2018001291A1 (fr)
CO (1) CO2018005915A2 (fr)
CR (1) CR20180311A (fr)
CY (1) CY1120303T1 (fr)
DK (1) DK3191511T3 (fr)
DO (1) DOP2018000122A (fr)
EC (1) ECSP18042569A (fr)
ES (1) ES2662418T3 (fr)
GT (1) GT201800095A (fr)
HK (1) HK1248716A1 (fr)
HR (1) HRP20171949T1 (fr)
HU (1) HUE035805T2 (fr)
IL (2) IL310373A (fr)
LT (1) LT3191511T (fr)
MA (1) MA41653A (fr)
MD (1) MD3191511T2 (fr)
ME (1) ME02954B (fr)
MX (1) MX2018005992A (fr)
NO (1) NO2768984T3 (fr)
PE (1) PE20181317A1 (fr)
PH (1) PH12018501025A1 (fr)
PL (1) PL3191511T3 (fr)
PT (1) PT3191511T (fr)
RS (1) RS56676B1 (fr)
SG (1) SG11201803975SA (fr)
SI (1) SI3191511T1 (fr)
TN (1) TN2018000159A1 (fr)
WO (1) WO2017081320A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
CN108659121A (zh) 2011-06-23 2018-10-16 埃博灵克斯股份有限公司 用于预测、检测和减少涉及免疫球蛋白单可变结构域的测定法中的非特异性蛋白干扰的技术
HUE050007T2 (hu) 2014-05-16 2020-11-30 Ablynx Nv Immunglobulin variábilis domének
NO2768984T3 (fr) * 2015-11-12 2018-06-09
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
WO2021110817A1 (fr) 2019-12-06 2021-06-10 Ablynx Nv Polypeptides comprenant des domaines variables uniques d'immunoglobuline ciblant tnfa et ox40l
IL293561A (en) 2019-12-06 2022-08-01 Ablynx Nv Polypeptides comprising immunoglobulin with one variable domain targeting TNFa and IL-23
CN112300289B (zh) * 2019-12-30 2022-06-10 中国药科大学 RGD4C融合抗TNFα纳米抗体蛋白、制备方法及其应用
KR20230123497A (ko) * 2020-12-18 2023-08-23 아블린쓰 엔.브이. IL-6 및 TNF-α를 표적화하는 면역글로불린 단일 가변도메인을 포함하는 폴리펩티드
WO2024097571A1 (fr) * 2022-11-04 2024-05-10 St. Jude Children's Research Hospital, Inc. Modulateurs de nlrp12 et nlrc5 et leurs procédés d'utilisation pour moduler des maladies

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DK0656946T4 (da) 1992-08-21 2010-07-26 Univ Bruxelles Immunoglobuliner uden lette kæder
EP0739981A1 (fr) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Fragments variables d'immunoglobulines-utilisation thérapeutique ou vétérinaire
WO1999023221A2 (fr) 1997-10-27 1999-05-14 Unilever Plc Proteines multivalentes de fixation de l'antigene
CA2321199A1 (fr) 1998-02-19 1999-08-26 William A. Brady Compositions et procedes de regulation de l'activation des lymphocytes
US20060002935A1 (en) 2002-06-28 2006-01-05 Domantis Limited Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
WO2004041865A2 (fr) * 2002-11-08 2004-05-21 Ablynx N.V. Anticorps a domaine unique stabilises
JP2006517789A (ja) 2003-01-10 2006-08-03 アブリンクス エン.ヴェー. 治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用
CA2529819A1 (fr) 2003-06-30 2004-09-23 Domantis Limited Anticorps a domaine unique pegyles
ATE485307T1 (de) 2003-11-07 2010-11-15 Ablynx Nv Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung
KR20070084170A (ko) 2004-10-13 2007-08-24 아블린쓰 엔.브이. 알쯔하이머병 등의 퇴행성 신경 질환의 치료 및 진단을위한 단일 도메인 카멜리드 항-아밀로이드 베타 항체 및이를 포함하는 폴리펩타이드
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CN103254309B (zh) * 2005-05-18 2017-09-26 埃博灵克斯股份有限公司 针对肿瘤坏死因子α的改进的纳米体TM
CA2960105A1 (fr) 2005-05-20 2006-11-23 Ablynx Nv Nanobodies (nanocorps) perfectionnes pour traiter des troubles medies par une agregation
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JP2012517818A (ja) * 2009-02-19 2012-08-09 グラクソ グループ リミテッド 改善された抗tnfr1ポリペプチド、抗体可変ドメインおよびアンタゴニスト
JP5647222B2 (ja) 2009-04-10 2014-12-24 アブリンクス エン.ヴェー. Il−6r関連疾患及び障害の治療のためのil−6rに指向性を有する改善されたアミノ酸配列及びこれを含むポリペプチド
WO2010130832A2 (fr) 2009-05-15 2010-11-18 Ablynx N.V. Séquences d'acides aminés dirigées contre dickkopf-1 et polypeptides comprenant ces dernières pour le traitement de maladies et de pathologies associées à la déperdition osseuse et/ou à l'ostéolyse
EA201270174A1 (ru) 2009-07-16 2012-07-30 Глэксо Груп Лимитед Отдельные связывающиеся вариабельные домены с улучшенными свойствами, направленные против сывороточного альбумина
US9120855B2 (en) 2010-02-10 2015-09-01 Novartis Ag Biologic compounds directed against death receptor 5
CN103917560B (zh) 2011-03-28 2017-05-24 埃博灵克斯股份有限公司 双特异性抗‑cxcr7免疫球蛋白单可变结构域
AU2012271974B2 (en) 2011-06-23 2017-01-12 Ablynx Nv Serum albumin binding proteins
CN108659121A (zh) * 2011-06-23 2018-10-16 埃博灵克斯股份有限公司 用于预测、检测和减少涉及免疫球蛋白单可变结构域的测定法中的非特异性蛋白干扰的技术
EA027160B1 (ru) * 2011-08-17 2017-06-30 Глаксо Груп Лимитед Модифицированные белки и пептиды
WO2014111550A1 (fr) 2013-01-17 2014-07-24 Glaxosmithkline Intellectual Property Development Limited Protéines de liaison modifiées anti-albumine sérique
HUE050007T2 (hu) * 2014-05-16 2020-11-30 Ablynx Nv Immunglobulin variábilis domének
NO2768984T3 (fr) * 2015-11-12 2018-06-09

Also Published As

Publication number Publication date
DK3191511T3 (en) 2018-01-08
AU2016352943A1 (en) 2018-06-07
BR112018009714A8 (pt) 2019-02-26
RS56676B1 (sr) 2018-03-30
RU2018120524A (ru) 2019-12-13
CY1120303T1 (el) 2019-07-10
CN108473563B (zh) 2022-06-14
KR20180083382A (ko) 2018-07-20
IL259269A (en) 2018-07-31
EP3266798A2 (fr) 2018-01-10
CO2018005915A2 (es) 2018-06-20
JP7357038B2 (ja) 2023-10-05
DOP2018000122A (es) 2018-09-30
PH12018501025A1 (en) 2019-01-28
JP6962915B2 (ja) 2021-11-10
KR102641194B1 (ko) 2024-02-26
CA3005085A1 (fr) 2017-05-18
CA3234178A1 (fr) 2017-05-18
AU2023200113A1 (en) 2023-02-16
BR112018009714A2 (pt) 2018-11-21
EP3266798A3 (fr) 2018-03-28
EP3191511A1 (fr) 2017-07-19
KR20240029115A (ko) 2024-03-05
ES2662418T3 (es) 2018-04-06
NO2768984T3 (fr) 2018-06-09
US20170190769A1 (en) 2017-07-06
US20170267752A1 (en) 2017-09-21
SG11201803975SA (en) 2018-06-28
CL2018001291A1 (es) 2018-09-14
WO2017081320A1 (fr) 2017-05-18
PL3191511T3 (pl) 2018-03-30
ME02954B (fr) 2018-07-20
ECSP18042569A (es) 2018-07-31
LT3191511T (lt) 2018-01-10
IL259269B1 (en) 2024-03-01
CR20180311A (es) 2018-10-18
US9745372B2 (en) 2017-08-29
JP2022020666A (ja) 2022-02-01
TN2018000159A1 (en) 2019-10-04
HK1248716A1 (zh) 2018-10-19
SI3191511T1 (en) 2018-01-31
CN108473563A (zh) 2018-08-31
EP3191511B1 (fr) 2017-09-20
HRP20171949T1 (hr) 2018-01-26
AU2016352943B2 (en) 2022-10-20
PT3191511T (pt) 2017-11-30
MD3191511T2 (ro) 2018-03-31
IL310373A (en) 2024-03-01
HUE035805T2 (en) 2018-05-28
GT201800095A (es) 2019-08-15
US10544211B2 (en) 2020-01-28
MX2018005992A (es) 2019-01-31
PE20181317A1 (es) 2018-08-14
RU2018120524A3 (fr) 2020-09-24
JP2019506839A (ja) 2019-03-14

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