KR20240013846A - 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 - Google Patents
항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 Download PDFInfo
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- KR20240013846A KR20240013846A KR1020247001621A KR20247001621A KR20240013846A KR 20240013846 A KR20240013846 A KR 20240013846A KR 1020247001621 A KR1020247001621 A KR 1020247001621A KR 20247001621 A KR20247001621 A KR 20247001621A KR 20240013846 A KR20240013846 A KR 20240013846A
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- South Korea
- Prior art keywords
- methyl
- pyridin
- oxy
- alkyl
- pyrimidin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
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- Hematology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
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- Neurology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020267005630A KR20260042557A (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361792812P | 2013-03-15 | 2013-03-15 | |
| US61/792,812 | 2013-03-15 | ||
| KR1020227016381A KR102628583B1 (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
| PCT/US2014/029661 WO2014145025A2 (en) | 2013-03-15 | 2014-03-14 | 2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227016381A Division KR102628583B1 (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020267005630A Division KR20260042557A (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240013846A true KR20240013846A (ko) | 2024-01-30 |
Family
ID=51529950
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247001621A Ceased KR20240013846A (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
| KR1020267005630A Pending KR20260042557A (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
| KR1020227016381A Active KR102628583B1 (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
| KR1020217026183A Active KR102399891B1 (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
| KR1020157029134A Active KR102293086B1 (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020267005630A Pending KR20260042557A (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
| KR1020227016381A Active KR102628583B1 (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
| KR1020217026183A Active KR102399891B1 (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
| KR1020157029134A Active KR102293086B1 (ko) | 2013-03-15 | 2014-03-14 | 항암 및 항-증식 활성을 나타내는 2-아미노피리미딘-6-온 및 유사체 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9181223B2 (https=) |
| EP (1) | EP2968286B1 (https=) |
| JP (6) | JP6165314B2 (https=) |
| KR (5) | KR20240013846A (https=) |
| CN (2) | CN105120864B (https=) |
| AU (5) | AU2014233411B2 (https=) |
| BR (1) | BR112015022288B1 (https=) |
| CA (1) | CA2903285C (https=) |
| DK (1) | DK2968286T3 (https=) |
| ES (1) | ES2651165T3 (https=) |
| IL (4) | IL241000B (https=) |
| MX (1) | MX365574B (https=) |
| NL (1) | NL301373I2 (https=) |
| PH (1) | PH12015502114B1 (https=) |
| PT (1) | PT2968286T (https=) |
| RU (1) | RU2015143717A (https=) |
| SG (1) | SG11201507660TA (https=) |
| WO (1) | WO2014145025A2 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| CA2903285C (en) * | 2013-03-15 | 2021-05-11 | Deciphera Pharmaceuticals, Llc | 2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
| AR109179A1 (es) | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
| EP3632906B1 (en) * | 2017-05-24 | 2023-12-13 | Abbisko Therapeutics Co., Ltd. | Azaaryl derivative, preparation method therefor, and application thereof for use in pharmacy |
| US11180495B2 (en) | 2017-06-19 | 2021-11-23 | Abbisko Therapeutics Co., Ltd. | Nitrogen heteroaryl derivative having CSF1R inhibitory activity, and preparation method therefor and application thereof |
| IL276398B2 (en) | 2018-01-31 | 2026-03-01 | Deciphera Pharmaceuticals Llc | Combination therapy for mastocytosis |
| KR102708177B1 (ko) | 2018-01-31 | 2024-09-23 | 데시페라 파마슈티칼스, 엘엘씨. | 위장관 기질 종양의 치료를 위한 병용 요법 |
| CN110845476B (zh) * | 2018-08-21 | 2022-11-18 | 上海和誉生物医药科技有限公司 | 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用 |
| SMT202500389T1 (it) | 2018-12-28 | 2025-11-10 | Deciphera Pharmaceuticals Llc | Inibitori di csf1r per l'uso nel trattamento di tumori tenosinoviali a cellule giganti |
| EP3938363A1 (en) | 2019-03-11 | 2022-01-19 | Teva Pharmaceuticals International GmbH | Solid state forms of ripretinib |
| MX2021013662A (es) | 2019-05-10 | 2022-03-11 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de heteroarilaminopirimidina amida y metodos de uso de estos. |
| EP3966207B1 (en) | 2019-05-10 | 2023-11-01 | Deciphera Pharmaceuticals, LLC | Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
| IL325201A (en) | 2019-06-17 | 2026-02-01 | Deciphera Pharmaceuticals Llc | Aminopyrimidine amide autophagy inhibitors and methods of using them |
| LT4013412T (lt) | 2019-08-12 | 2026-03-25 | Deciphera Pharmaceuticals, Llc | Ripretinibas, skirtas virškinamojo trakto stromos navikų gydymui |
| PT4013412T (pt) | 2019-08-12 | 2026-03-18 | Deciphera Pharmaceuticals Llc | Ripretinib para o tratamento de tumores estromais gastrointestinais |
| CN115243681B (zh) | 2019-12-30 | 2024-08-16 | 德西费拉制药有限责任公司 | 1-(4-溴-5-(1-乙基-7-(甲氨基)-2-侧氧基-1,2-二氢-1,6-萘啶-3-基)-2-氟苯基)-3-苯基脲的组合物 |
| HRP20231699T1 (hr) | 2019-12-30 | 2024-05-10 | Deciphera Pharmaceuticals, Llc | Formulacije inhibitora amorfne kinaze i postupci njihove primjene |
| MX2023005747A (es) | 2020-11-18 | 2023-07-28 | Deciphera Pharmaceuticals Llc | Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos. |
| CN115385896B (zh) * | 2021-05-24 | 2024-11-15 | 上海和誉生物医药科技有限公司 | 一种csf-1r抑制剂中间体或其酸式盐的制备方法 |
| CN113880812A (zh) * | 2021-11-17 | 2022-01-04 | 上海皓元生物医药科技有限公司 | 一种csf-ir抑制剂的制备方法 |
| KR20240113496A (ko) | 2021-12-03 | 2024-07-22 | 데시페라 파마슈티칼스, 엘엘씨. | Gcn2 및 perk 키나아제 억제제로서의 헤테로고리 화합물 |
| US12319655B2 (en) | 2021-12-09 | 2025-06-03 | Deciphera Pharmaceuticals, Llc | RAF kinase inhibitors and methods of use thereof |
| CN118434727A (zh) * | 2021-12-31 | 2024-08-02 | 上海海雁医药科技有限公司 | 取代的嘧啶酮衍生物、其药物组合物及医药上的用途 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| CN117624132B (zh) * | 2023-11-28 | 2026-04-21 | 上海相辉医药科技有限公司 | 一种CSF-1R激酶抑制剂Vimseltinib(DCC-3014)的制备方法 |
| WO2025122952A1 (en) * | 2023-12-08 | 2025-06-12 | Deciphera Pharmaceuticals, Llc | Formulations of vimseltinib |
| US20250206720A1 (en) | 2023-12-08 | 2025-06-26 | Deciphera Pharmaceuticals, Llc | Solid forms of an ulk inhibitor |
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| US20080255155A1 (en) * | 2006-10-18 | 2008-10-16 | Stephane Raeppel | Kinase inhibitors and uses thereof |
| EP2125781A2 (en) * | 2006-12-20 | 2009-12-02 | Amgen Inc. | Substituted heterocycles and methods of use |
| CN102256493A (zh) * | 2008-10-29 | 2011-11-23 | 迪赛孚尔制药有限公司 | 表现出抗癌活性和抗增殖活性的环丙烷酰胺及其类似物 |
| US9193719B2 (en) | 2013-03-15 | 2015-11-24 | Deciphera Pharmaceuticals, Llc | 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
| CA2903285C (en) * | 2013-03-15 | 2021-05-11 | Deciphera Pharmaceuticals, Llc | 2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
| US9133183B2 (en) * | 2013-03-15 | 2015-09-15 | Deciphera Pharmaceuticals, Llc | Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities |
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