KR20230159562A - 단백질 키나제 c(pkc)에서 작용하는 디테르페노이드 화합물 - Google Patents
단백질 키나제 c(pkc)에서 작용하는 디테르페노이드 화합물 Download PDFInfo
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- KR20230159562A KR20230159562A KR1020237036087A KR20237036087A KR20230159562A KR 20230159562 A KR20230159562 A KR 20230159562A KR 1020237036087 A KR1020237036087 A KR 1020237036087A KR 20237036087 A KR20237036087 A KR 20237036087A KR 20230159562 A KR20230159562 A KR 20230159562A
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- Prior art keywords
- alkyl
- cycloalkyl
- independently
- cancer
- optionally substituted
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
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- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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- A61K31/415—1,2-Diazoles
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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- C07C69/63—Halogen-containing esters of saturated acids
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07—ORGANIC CHEMISTRY
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- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
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- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163164704P | 2021-03-23 | 2021-03-23 | |
| US63/164,704 | 2021-03-23 | ||
| PCT/US2022/021609 WO2022204327A1 (en) | 2021-03-23 | 2022-03-23 | Diterpenoid compounds that act on protein kinase c (pkc) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230159562A true KR20230159562A (ko) | 2023-11-21 |
Family
ID=83396064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237036087A Pending KR20230159562A (ko) | 2021-03-23 | 2022-03-23 | 단백질 키나제 c(pkc)에서 작용하는 디테르페노이드 화합물 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240197666A1 (https=) |
| EP (1) | EP4313095A4 (https=) |
| JP (1) | JP2024512046A (https=) |
| KR (1) | KR20230159562A (https=) |
| CN (1) | CN117098544A (https=) |
| AU (1) | AU2022241774A1 (https=) |
| CA (1) | CA3212440A1 (https=) |
| IL (1) | IL305623A (https=) |
| WO (1) | WO2022204327A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL291697B2 (en) * | 2019-09-24 | 2025-07-01 | K Gen Inc | Diterpenoid compounds acting on protein kinase (pkc c) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070129282A1 (en) * | 1998-11-24 | 2007-06-07 | Ahlem Clarence N | Pharmaceutical treatments and compositions |
| US6890904B1 (en) * | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| AU2002951253A0 (en) * | 2002-09-06 | 2002-09-19 | Medvet Science Pty. Ltd. | A method of modulating cellular activity |
| US12502369B2 (en) * | 2015-11-11 | 2025-12-23 | K-Gen, Inc. | Methods of cancer treatment |
| WO2017156350A1 (en) * | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
| US20220226281A1 (en) * | 2019-05-30 | 2022-07-21 | Sirenas Llc | Compounds for use in anti-cancer immunotherapy |
| IL291697B2 (en) * | 2019-09-24 | 2025-07-01 | K Gen Inc | Diterpenoid compounds acting on protein kinase (pkc c) |
-
2022
- 2022-03-23 US US18/283,787 patent/US20240197666A1/en active Pending
- 2022-03-23 CN CN202280024030.9A patent/CN117098544A/zh active Pending
- 2022-03-23 WO PCT/US2022/021609 patent/WO2022204327A1/en not_active Ceased
- 2022-03-23 JP JP2023558444A patent/JP2024512046A/ja active Pending
- 2022-03-23 IL IL305623A patent/IL305623A/en unknown
- 2022-03-23 CA CA3212440A patent/CA3212440A1/en active Pending
- 2022-03-23 EP EP22776602.9A patent/EP4313095A4/en active Pending
- 2022-03-23 AU AU2022241774A patent/AU2022241774A1/en active Pending
- 2022-03-23 KR KR1020237036087A patent/KR20230159562A/ko active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240197666A1 (en) | 2024-06-20 |
| JP2024512046A (ja) | 2024-03-18 |
| AU2022241774A1 (en) | 2023-09-21 |
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