CN117098544A - 作用于蛋白激酶c(pkc)的二萜化合物 - Google Patents

作用于蛋白激酶c(pkc)的二萜化合物 Download PDF

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Publication number
CN117098544A
CN117098544A CN202280024030.9A CN202280024030A CN117098544A CN 117098544 A CN117098544 A CN 117098544A CN 202280024030 A CN202280024030 A CN 202280024030A CN 117098544 A CN117098544 A CN 117098544A
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alkyl
cycloalkyl
independently
cancer
optionally substituted
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Chinese (zh)
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R·陈
C·江
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K Gen Treatment Co ltd
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K Gen Treatment Co ltd
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Dermatology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
CN202280024030.9A 2021-03-23 2022-03-23 作用于蛋白激酶c(pkc)的二萜化合物 Pending CN117098544A (zh)

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US202163164704P 2021-03-23 2021-03-23
US63/164,704 2021-03-23
PCT/US2022/021609 WO2022204327A1 (en) 2021-03-23 2022-03-23 Diterpenoid compounds that act on protein kinase c (pkc)

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US (1) US20240197666A1 (https=)
EP (1) EP4313095A4 (https=)
JP (1) JP2024512046A (https=)
KR (1) KR20230159562A (https=)
CN (1) CN117098544A (https=)
AU (1) AU2022241774A1 (https=)
CA (1) CA3212440A1 (https=)
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IL291697B2 (en) * 2019-09-24 2025-07-01 K Gen Inc Diterpenoid compounds acting on protein kinase (pkc c)

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US20070129282A1 (en) * 1998-11-24 2007-06-07 Ahlem Clarence N Pharmaceutical treatments and compositions
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
AU2002951253A0 (en) * 2002-09-06 2002-09-19 Medvet Science Pty. Ltd. A method of modulating cellular activity
US12502369B2 (en) * 2015-11-11 2025-12-23 K-Gen, Inc. Methods of cancer treatment
WO2017156350A1 (en) * 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
US20220226281A1 (en) * 2019-05-30 2022-07-21 Sirenas Llc Compounds for use in anti-cancer immunotherapy
IL291697B2 (en) * 2019-09-24 2025-07-01 K Gen Inc Diterpenoid compounds acting on protein kinase (pkc c)

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AU2022241774A1 (en) 2023-09-21
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EP4313095A1 (en) 2024-02-07
IL305623A (en) 2023-11-01
WO2022204327A1 (en) 2022-09-29
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KR20230159562A (ko) 2023-11-21

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