KR20230124037A - 종양 특이적 claudin 18.2 항체-약물 접합체 - Google Patents

종양 특이적 claudin 18.2 항체-약물 접합체 Download PDF

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KR20230124037A
KR20230124037A KR1020237024767A KR20237024767A KR20230124037A KR 20230124037 A KR20230124037 A KR 20230124037A KR 1020237024767 A KR1020237024767 A KR 1020237024767A KR 20237024767 A KR20237024767 A KR 20237024767A KR 20230124037 A KR20230124037 A KR 20230124037A
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antibody
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val
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루카스 바메르트
렌카 키리츠 사딜코바
시모나 호스코바
이바 발렌토바
로렌츠 왈트마이어
로저 베엘리
울리히 뫼비우스
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소티오 바이오테크 에이.에스.
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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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KR1020237024767A 2020-12-23 2021-12-23 종양 특이적 claudin 18.2 항체-약물 접합체 Withdrawn KR20230124037A (ko)

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EP20216800 2020-12-23
EP20216800.1 2020-12-23
PCT/EP2021/087495 WO2022136642A1 (en) 2020-12-23 2021-12-23 Tumor-specific claudin 18.2 antibody-drug conjugates

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JP (1) JP2024500242A (cg-RX-API-DMAC7.html)
KR (1) KR20230124037A (cg-RX-API-DMAC7.html)
CN (1) CN116635085A (cg-RX-API-DMAC7.html)
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CA (1) CA3199830A1 (cg-RX-API-DMAC7.html)
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CN111808194B (zh) 2020-07-13 2021-04-20 北京凯因科技股份有限公司 一种结合密蛋白的用于治疗癌症的人源化抗体

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