KR20230051214A - 항체 약물 접합체 - Google Patents

항체 약물 접합체 Download PDF

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KR20230051214A
KR20230051214A KR1020237007880A KR20237007880A KR20230051214A KR 20230051214 A KR20230051214 A KR 20230051214A KR 1020237007880 A KR1020237007880 A KR 1020237007880A KR 20237007880 A KR20237007880 A KR 20237007880A KR 20230051214 A KR20230051214 A KR 20230051214A
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South Korea
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ser
val
gly
thr
antibody
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Korean (ko)
Inventor
시콴 좡
티안시 첸
웨이웨이 펭
빙 좡
샤오치 탕
통지에 수
샤오진 왕
후아스 셍
젱핑 좡
후아 왕
용 가오
Original Assignee
치아타이 티안큉 파마수티컬 그룹 주식회사
난징 슌신 파마슈티컬스 코., 엘티디. 오브 치아타이 티앤칭 파마슈티컬 그룹
난징 šœ신 파마슈티컬스 코., 엘티디. 오브 치아타이 티앤칭 파마슈티컬 그룹
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Application filed by 치아타이 티안큉 파마수티컬 그룹 주식회사, 난징 슌신 파마슈티컬스 코., 엘티디. 오브 치아타이 티앤칭 파마슈티컬 그룹, 난징 šœ신 파마슈티컬스 코., 엘티디. 오브 치아타이 티앤칭 파마슈티컬 그룹 filed Critical 치아타이 티안큉 파마수티컬 그룹 주식회사
Publication of KR20230051214A publication Critical patent/KR20230051214A/ko
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    • AHUMAN NECESSITIES
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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6875Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
    • A61K47/6879Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
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    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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KR1020237007880A 2020-08-13 2021-08-13 항체 약물 접합체 Pending KR20230051214A (ko)

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CN202010814877.X 2020-08-13
CN202010814877 2020-08-13
PCT/CN2021/112462 WO2022033578A1 (zh) 2020-08-13 2021-08-13 抗体药物偶联物

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US (1) US20230405141A1 (https=)
EP (1) EP4183421A4 (https=)
JP (1) JP2023537051A (https=)
KR (1) KR20230051214A (https=)
CN (8) CN119792562A (https=)
AU (1) AU2021323863A1 (https=)
BR (1) BR112023002417A2 (https=)
CA (1) CA3188508A1 (https=)
IL (1) IL300446A (https=)
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