KR20230017815A - 항-sars-cov-2 스파이크 당단백질 항체 및 항원-결합 단편 - Google Patents

항-sars-cov-2 스파이크 당단백질 항체 및 항원-결합 단편 Download PDF

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KR20230017815A
KR20230017815A KR1020227045049A KR20227045049A KR20230017815A KR 20230017815 A KR20230017815 A KR 20230017815A KR 1020227045049 A KR1020227045049 A KR 1020227045049A KR 20227045049 A KR20227045049 A KR 20227045049A KR 20230017815 A KR20230017815 A KR 20230017815A
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antibody
antigen
cov
binding fragment
sars
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알리나 바움
벤자민 풀턴
크리스토스 키라트소우스
조지 디. 얀코포울러스
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리제너론 파아마슈티컬스, 인크.
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KR1020227045049A 2020-05-26 2021-05-26 항-sars-cov-2 스파이크 당단백질 항체 및 항원-결합 단편 Pending KR20230017815A (ko)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US202063030260P 2020-05-26 2020-05-26
US63/030,260 2020-05-26
US202063033198P 2020-06-01 2020-06-01
US63/033,198 2020-06-01
US202063093888P 2020-10-20 2020-10-20
US63/093,888 2020-10-20
US202063112143P 2020-11-10 2020-11-10
US63/112,143 2020-11-10
US202163141956P 2021-01-26 2021-01-26
US63/141,956 2021-01-26
US202163142472P 2021-01-27 2021-01-27
US63/142,472 2021-01-27
US202163145389P 2021-02-03 2021-02-03
US63/145,389 2021-02-03
US202163159437P 2021-03-10 2021-03-10
US63/159,437 2021-03-10
PCT/US2021/034187 WO2021242815A1 (en) 2020-05-26 2021-05-26 Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments

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KR20230017815A true KR20230017815A (ko) 2023-02-06

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KR1020227045049A Pending KR20230017815A (ko) 2020-05-26 2021-05-26 항-sars-cov-2 스파이크 당단백질 항체 및 항원-결합 단편

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US (1) US20240043504A1 (https=)
EP (1) EP4157868A1 (https=)
JP (1) JP2023527352A (https=)
KR (1) KR20230017815A (https=)
CN (1) CN116096745A (https=)
AU (1) AU2021282179A1 (https=)
BR (1) BR112022024149A2 (https=)
CA (1) CA3179819A1 (https=)
IL (1) IL298194A (https=)
MX (1) MX2022014598A (https=)
WO (1) WO2021242815A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250107297A (ko) 2020-04-02 2025-07-11 리제너론 파아마슈티컬스, 인크. 항-sars-cov-2 스파이크 당단백질 항체 및 항원-결합 단편
BR112022024662A2 (pt) 2020-06-03 2023-04-04 Regeneron Pharma Métodos para tratamento ou prevenção de infecções por sars-cov-2 e covid-19 com anticorpos de glicoproteína spike anti-sars-cov-2
US12496470B2 (en) 2021-07-14 2025-12-16 Regeneron Pharmaceuticals, Inc. Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments
US20250049006A1 (en) * 2021-12-20 2025-02-13 C/O Regeneron Pharmaceuticals, Inc. Non-human animals comprising humanized ace2 and tmprss loci
WO2023173577A1 (zh) * 2022-03-15 2023-09-21 慧壹科技(上海)有限公司 冠状病毒抗体及其用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US5693489A (en) 1984-03-30 1997-12-02 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US4959455A (en) 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
CA2704600C (en) 1999-04-09 2016-10-25 Kyowa Kirin Co., Ltd. A method for producing antibodies with increased adcc activity
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
EP2314620B1 (en) * 2004-05-27 2013-06-05 Crucell Holland B.V. Method of identifying binding molecules capable of neutralizing rabies virus
JP5307708B2 (ja) 2006-06-02 2013-10-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒトil−6受容体に対する高親和性抗体
WO2008020079A1 (en) 2006-08-18 2008-02-21 Ablynx N.V. Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
US7737725B1 (en) 2008-04-04 2010-06-15 Xilinx, Inc. Device control register for a processor block
EP2285833B1 (en) 2008-05-16 2014-12-17 Ablynx N.V. AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME
US8409838B2 (en) 2009-06-02 2013-04-02 Regeneron Pharmaceuticals, Inc. Fucosylation-deficient cells
US20150203591A1 (en) 2012-08-02 2015-07-23 Regeneron Pharmaceuticals, Inc. Mutivalent antigen-binding proteins
JO3701B1 (ar) 2014-05-23 2021-01-31 Regeneron Pharma مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
CN111936517B (zh) 2018-01-26 2025-04-18 瑞泽恩制药公司 抗tmprss2抗体和抗原结合片段
KR20250107297A (ko) 2020-04-02 2025-07-11 리제너론 파아마슈티컬스, 인크. 항-sars-cov-2 스파이크 당단백질 항체 및 항원-결합 단편

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US20240043504A1 (en) 2024-02-08
CA3179819A1 (en) 2021-12-02
WO2021242815A1 (en) 2021-12-02
EP4157868A1 (en) 2023-04-05
MX2022014598A (es) 2023-03-31
CN116096745A (zh) 2023-05-09
BR112022024149A2 (pt) 2023-02-07
AU2021282179A1 (en) 2023-01-19
JP2023527352A (ja) 2023-06-28
IL298194A (en) 2023-01-01

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