KR20230007406A - 넥틴-4 (nectin-4) 에 대한 항체 및 이의 응용 - Google Patents

넥틴-4 (nectin-4) 에 대한 항체 및 이의 응용 Download PDF

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KR20230007406A
KR20230007406A KR1020227040582A KR20227040582A KR20230007406A KR 20230007406 A KR20230007406 A KR 20230007406A KR 1020227040582 A KR1020227040582 A KR 1020227040582A KR 20227040582 A KR20227040582 A KR 20227040582A KR 20230007406 A KR20230007406 A KR 20230007406A
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cdr
amino acid
seq
acid sequence
homology
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Korean (ko)
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홍위안 렌
지안 주
지안 린
리춘 왕
샤오홍 쑤
샤오팡 뎅
지엔준 비
진 왕
지안 우
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맵웰 (상하이) 바이오사이언스 컴퍼니, 리미티드
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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KR1020227040582A 2020-04-21 2021-04-21 넥틴-4 (nectin-4) 에 대한 항체 및 이의 응용 Pending KR20230007406A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010320420.3A CN113527486B (zh) 2020-04-21 2020-04-21 一种抗Nectin-4的抗体及其应用
CN202010320420.3 2020-04-21
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Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4096717B1 (en) 2020-01-31 2024-12-11 Innate Pharma Treatment of cancer
CN113527486B (zh) * 2020-04-21 2025-12-02 迈威(上海)生物科技股份有限公司 一种抗Nectin-4的抗体及其应用
US20230181749A1 (en) * 2020-05-20 2023-06-15 Bicycle TX Limited Bicyclic peptide ligands specific for nectin-4 and uses thereof
MX2023005873A (es) * 2020-11-25 2023-06-05 Innate Pharma Tratamiento del cancer.
CA3217112A1 (en) * 2021-04-30 2022-11-03 Wei Zhou Antibody-drug conjugate targeting nectin-4 and preparation method therefor and use thereof
US20240366778A1 (en) * 2021-08-27 2024-11-07 Cspc Megalith Biopharmarceutical Co., Ltd. Anti-nectin-4 antibody, drug conjugate, and preparation method therefor and use thereof
CN116478279A (zh) * 2021-12-31 2023-07-25 武汉瑞法医疗器械有限公司 乙型肝炎病毒表面抗原纳米抗体吸附剂及制备方法和应用
CN116063498A (zh) * 2022-04-27 2023-05-05 博际生物医药科技(杭州)有限公司 单域抗Nectin-4抗体
CN114702589B (zh) * 2022-04-27 2022-11-01 博际生物医药科技(杭州)有限公司 治疗癌症的组合物和方法
CN114702588B (zh) * 2022-04-27 2022-11-22 博际生物医药科技(杭州)有限公司 抗Nectin-4抗体和双特异性抗体
AU2023273063A1 (en) * 2022-05-16 2024-11-14 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition containing anti-nectin-4 antibody drug conjugate and use thereof
CA3262070A1 (en) * 2022-07-14 2025-06-13 Bio-Thera Solutions, Ltd. ANTI-NECTIN-4 ANTIBODIES AND THEIR USES
CN115368463B (zh) * 2022-07-19 2025-12-19 合肥天港免疫药物有限公司 双特异性抗体及其应用
EP4324849A1 (en) * 2022-08-18 2024-02-21 Emergence Therapeutics AG Humanized anti-nectin-4 antibodies
CN120239708A (zh) * 2022-09-20 2025-07-01 耐科廷疗法有限公司 针对黏连蛋白4的人源化抗体及其药物偶联物
EP4609880A1 (en) * 2022-10-28 2025-09-03 Jiangsu Mabwell Health Pharmaceutical R&D Co., Ltd. Preparation containing anti-nectin-4 antibody drug conjugate and use thereof
CN115877008A (zh) * 2022-12-05 2023-03-31 中国科学院自动化研究所 用于膀胱癌检测的光学分子成像探针及其制备方法和应用
JP2026508244A (ja) * 2023-02-22 2026-03-10 ナンジング リーズ バイオラブズ シーオー．， エルティーディー． 抗Ｎｅｃｔｉｎ－４抗体及びそれを含む多重特異性抗体
AU2024228349A1 (en) * 2023-02-27 2025-09-11 CSPC Megalith Biopharmaceutical Co., Ltd. Pharmaceutical composition of recombinant humanized anti-nectin-4 monoclonal antibody-mmae conjugate drug
CN116381251B (zh) * 2023-03-13 2024-06-25 柏定生物工程(北京)有限公司 一种肿瘤标志物诊断试剂盒及其诊断方法
CN116589584B (zh) * 2023-05-24 2025-02-14 深圳市先康达生命科学有限公司 靶向人Nectin4蛋白的抗体或其片段和应用
WO2024251260A1 (zh) * 2023-06-08 2024-12-12 江苏迈威康新药研发有限公司 结合Nectin-4的抗体及其用途
CN119390781B (zh) * 2023-08-04 2026-04-17 湖南中晟全肽生物科技股份有限公司 特异性结合Nectin-4的多肽及其用途
EP4534101A1 (en) 2023-10-02 2025-04-09 Eli Lilly and Company Antibody drug conjugate (adc) targeting nectin 4 and comprising an exatecan payload
TW202535960A (zh) * 2024-01-08 2025-09-16 大陸商上海橙帆醫藥有限公司 抗體及其藥物偶聯物和用途
CN117964682A (zh) * 2024-01-12 2024-05-03 杭州爱科瑞思生物医药有限公司 Dolastatin衍生物及其制备方法和应用
CN120383674A (zh) * 2024-01-26 2025-07-29 鲁南新时代生物技术有限公司 一种Nectin-4抗体及其应用
WO2025162493A1 (zh) * 2024-01-29 2025-08-07 甘李药业股份有限公司 抗Nectin-4抗体、配体药物偶联物及其应用
WO2025195487A1 (zh) * 2024-03-21 2025-09-25 石药集团巨石生物制药有限公司 靶向Nectin-4的抗体药物缀合物的用途
CN117986367B (zh) * 2024-04-02 2024-07-16 上海美迪西生物医药股份有限公司 靶点为Nectin-4的抗体及其应用
WO2025222063A2 (en) * 2024-04-17 2025-10-23 Marengo Therapeutics, Inc. Multifunctional molecules binding to tcr and uses thereof
KR20250177512A (ko) * 2024-06-14 2025-12-24 삼성바이오에피스 주식회사 신규한 항-넥틴-4 항체 및 이의 용도
WO2026008043A1 (zh) * 2024-07-04 2026-01-08 石药集团巨石生物制药有限公司 靶向Nectin-4的抗体药物缀合物和免疫检查点抑制剂联合的用途
WO2026057016A1 (en) * 2024-09-12 2026-03-19 LaNova Medicines Limited Anti-nectin-4 antibodies and conjugates thereof
CN119930825A (zh) * 2025-02-13 2025-05-06 哈尔滨医科大学 一种Nectin-4靶向的纳米抗体及其在制备治疗膀胱癌的产品中的应用
CN120271712A (zh) * 2025-04-18 2025-07-08 哈尔滨医科大学 靶向Nectin-4的纳米抗体及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080268476A1 (en) * 2004-05-12 2008-10-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nectin 4 (N4) as a Marker for Cancer Prognosis
JPWO2008044754A1 (ja) * 2006-10-06 2010-02-18 武田薬品工業株式会社 癌の予防・治療剤
WO2011112566A2 (en) * 2010-03-11 2011-09-15 Abbott Laboratories Basigin binding proteins
EP3347048B1 (en) * 2015-09-09 2020-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to nectin-4 and uses thereof
BR112018074453A2 (pt) * 2016-05-27 2019-03-19 Abbvie Biotherapeutics Inc. proteínas de ligação biespecíficas ligando uma protéina imunomoduladora e um antígeno tumoral
CN109810039B (zh) 2017-11-22 2021-11-12 迈威(上海)生物科技股份有限公司 一种用于抗体-药物偶联的双取代马来酰胺类连接子及其制备方法和用途
CN110392697A (zh) * 2017-03-02 2019-10-29 国家医疗保健研究所 对nectin-4具有特异性的抗体及其用途
WO2018226578A1 (en) 2017-06-05 2018-12-13 Agensys, Inc. Nectin-4-binding proteins and methods of use thereof
KR102892725B1 (ko) * 2018-05-09 2025-12-01 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. 인간 넥틴4에 특이적인 항체
CN113527486B (zh) * 2020-04-21 2025-12-02 迈威(上海)生物科技股份有限公司 一种抗Nectin-4的抗体及其应用

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