KR20220159536A - Manufacturing method of Medical Herb Tea for Preventing and Alleviating Dementia - Google Patents

Abstract

The present invention relates to a preparation method of medicinal herbal tea for preventing and alleviating dementia, which comprises: a first step of adding 60 ℓ of water to 30 ㎏ of puffed rice to steam the mixture in a steamer at 1.2 ㎏/㎠ and 110 ℃ for 30 minutes and adding 80 g of aspergillus kawachii to culture the mixture in a thermo-hygrostat at 26 ℃ for 40 hours to prepare koji; a second step of fermenting 4 ㎏ of the koji, 6 ㎏ of water, and 5 g of yeast at 25-30 ℃ for 6 days to prepare mother liquor; a third step of fermenting 10 ㎏ of the mother liquor, 50 ㎏ of the koji, 70 ㎏ of water, 1200 g of Angelica gigas roots, 1000 g of Siberian ginseng roots, 1000 g of ginkgo leaves, 800 g of Astragalus membranaceus, 700 g of Eucommia ulmoides, 640 g of Schisandra chinensis fruits, 640 g of Polygala tenuifolia roots, 640 g of Acorus gramineus roots, 640 g of Crataegus pinnatifida fruits, 640 g of Cervi Cornu, 500 g of cnidium officinale roots, 500 g of fructooligosaccharides, 400 g of Longan arillus fruits, 390 g of salvia miltiorrhiza roots, 300 g of licorice, and 10 g of a stevia extract at 22-23 ℃ for 6 months to prepare a first mashed product; a fourth step of fermenting 130 ㎏ of the first mashed product, 100 ㎏ of the puffed rice, 160 ㎏ of water, and 150 g of a purified enzyme at 15-16 ℃ for 3 days to prepare a second mashed product; and a fifth step of heating the second mashed product at 100-105 ℃ for 30-40 minutes to prepare medicinal herbal tea for preventing and alleviating dementia. Accordingly, the medicinal herbal tea of the present invention has excellent effects of alleviating dementia and has good taste.

Description

Manufacturing method of herbal tea for preventing and alleviating dementia {Manufacturing method of Medical Herb Tea for Preventing and Alleviating Dementia}

The present invention relates to a method for manufacturing herbal tea for preventing and improving dementia, and more particularly, to a method for manufacturing herbal tea for preventing and improving dementia, which has an excellent effect on improving dementia and has excellent taste.

Recently, in the midst of industrialization and environmental changes, modern people are exposed to various diseases due to reduced immunity due to various causes, and huge costs are consumed for the treatment of these diseases. In particular, due to recent polluted air and new life changes, allergic diseases excessively exaggerate the human immune system by various allergy triggers, resulting in TNF-α (tumor necrosis factor-α) and IL in immune cells such as macrophages. Inflammatory substances such as -1 (interleukin-1), IL-6 (interleukin-6), prostaglandin, leukotriene, MMP-9 (matrix metalloproteinase-9) and nitric oxide (NO) It is known that it induces excessively, which progresses to an inflammatory response, causing various diseases and immune hypersensitivity symptoms.

In addition, as the brain function is damaged due to the damage and loss of nerve cells due to the collapse of the immune system, dementia is developing, and the onset of dementia is gradually accelerating.

Dementia is a kind of syndrome in which cognitive function is continuously and generally deteriorated compared to the past as brain function is damaged due to various causes in people who have been living a normal life. Pathologically, memory is caused by damage and loss of nerve cells. It is a brain disease in which severe impairment in concentration, language, and cognition progresses gradually over a long period of time, ultimately leading to death. These causes of dementia include Alzheimer's disease, Vascular dementia, Parkinson's disease, Lewy body dementia, Huntington's disease, Creutzfeldt-Jakob disease Jacob disease), Pick's disease, etc. are known.

Among them, Alzheimer's disease (AD) is the most common degenerative brain disease and causes cognitive loss due to gradual degeneration of nerve cells. It is characterized by the accumulation of a 39-43 amino acid peptide termed fibrillar form of amyloid-β protein (Aβ), present as amyloid plaques and amyloid in brain tissue. In Alzheimer's disease, Aβ deposition is detrimental to neurons and interstitial cells in the brain, resulting in brain inflammation and neuronal death, which are characteristic features of Alzheimer's disease.

In the brains of patients who died of AD, senile plaques and neurofibrillary tangles appear as pathological features. Among them, senile plaque is formed by accumulation of proteins and dead cells outside cells, and its main component is a peptide called Amyloid-β (Aβ).

Progressive loss of cognitive function, a key feature of AD patients, appears to be caused by abnormally accumulated Aβ. Aβ is produced from amyloid precursor protein (hereinafter referred to as “APP”) through a proteolysis process. APP, a precursor, is degraded by β-secretase (BSCE) and γ-secretase to produce Aβ. However, when APP is cleaved by α-secretase, it inhibits the production of Aβ and induces the production of APPα, which has a neuroprotective effect. Therefore, increasing the activity of α-secretase is a method for treating or improving Alzheimer's disease. to be. In addition, when SIRT1 is activated in vivo, it activates α-secretase by deacetylating various transcriptional regulators.

On the other hand, nicotine receptor inhibitor ABT-418, muscarinic receptor inhibitor xanomeline, acetylcholine precursor lecithin, acetyl-L-carnitine, metal chelator desperioxamine, rioquinol, beta-sheet breaker iAβ5, iAβ11, Antioxidant vitamin E, ginkgo biloba extract, melatonin, idebenone, sAPP releaser nicotine, acetylcholine, carbachol, beta secretase or gamma secretase inhibitor OM99-1, OM99-2, OM99-3, Z-VLL -CHO and NSAIDs, which are anti-inflammatory drugs, are being developed, but most of them are insignificant because their effect is to alleviate some pathological symptoms or slow down the progress, or are difficult to apply in practice because of their toxicity, so they are stable and effective AD treatments. development is urgently needed.

Republic of Korea Patent Registration No. 10-2092509 (2020.03.23.) discloses a food composition for preventing and improving dementia.

The food composition for preventing and improving dementia has the advantage of having few side effects, but has a disadvantage in that the effect of improving dementia is insufficient.

KR 10-2092509 B1 2020.03.23.

An object of the present invention is to provide a method for manufacturing herbal tea for preventing and improving dementia, which is excellent in improving dementia.

Another object of the present invention is to provide a method for manufacturing herbal tea for preventing and improving dementia with excellent taste.

In order to achieve the above object, the present invention provides the following means.

In the present invention, after adding 60 liters of water to 30 kg of puffed rice and increasing it using a steamer at 1.2 kg / cm 2 at 110 ° C. for 30 minutes, 80 g of Aspergillus Kawachii was added and the mixture was kept in a thermo-hygrostat at 26 ° C. for 40 hours. Culturing to prepare the entry (step 1); Fermenting 4 kg of the entry, 6 kg of water, and 5 g of yeast at 25 to 30 ° C. for 6 days to prepare main hair (step 2); 10 kg of above hair, 50 kg of above seaweed, 70 kg of water, Angelica root 1200 g, Ginkgo ginseng root 1000 g, Ginkgo leaf 1000 g, Astragalus 800 g, Eucommia 700 g, Schisandra fruit 640 g, Wonji root 640 g, Iris root 640 g, Hawthorn fruit 640g, antler horn 640g, cnidium root 500g, fructo-oligosaccharide 500g, longan meat 400g, dansam root 390g, licorice 300g, and stevia extract 10g fermented at 22-23 ° C. for 6 months to obtain a first stock (step 3); fermenting 130 kg of the first feed, 100 kg of puffed rice, 160 kg of water, and 150 g of purified enzyme at 15-16° C. for 3 days to obtain a second feed (step 4); and preparing herbal tea for preventing and improving dementia by heating the second injection at 100 to 105° C. for 30 to 40 minutes (step 5); It provides a method for manufacturing herbal tea for preventing and improving dementia, comprising a.

In step 1, the expanded rice is mixed with 30 kg of non-glutinous rice and 30 kg of water, heated for 10 minutes in a pressure heater with an internal temperature of 100 ° C, dried in a vacuum dryer at 15 ° C and 120 Pa pressure, and then 100 to 150 mesh It is prepared by crushing

In the step 3, the stevia extract is immersed in 10 kg of stevia leaves in 20 liters of seaweed water for 12 hours, dried and pulverized, and then the pulverized product is put into a reactor of a supercritical extractor and CO ₂ gas is injected into the reactor. Rotate and maintain the pressure in the reactor at 60 atmospheres, CO ₂ is circulated, and the extract obtained is filtered, freeze-dried, and powdered to prepare, but the seaweed water is 80% by weight of seaweed, 15% by weight of plum, and 5% by weight of Schisandra chinensis. It is prepared by adding 1,000 parts by weight of goji berry extract to 100 parts by weight of the mixed mixture, heating at 100 to 105 ° C for 4 to 6 hours, and then filtering. It is prepared by heating at ℃ for 1 to 2 hours and then filtering.

After step 4, 1 to 3 parts by weight of 100 parts by weight of the second injection, 1 to 3 parts by weight of mountain ash extract, and 1 to 3 parts by weight of gold and silver flower extract are additionally included, and the 100 g of 100 g of 100 g of was added to 2 liters of 30% (v/v) ethanol aqueous solution and extracted at 25 ° C for 24 hours. The gold and silver flower extract is prepared by adding 100 g of gold and silver flowers to 2 liters of 70% (v/v) ethanol aqueous solution and extracting at 40° C. for 24 hours.

After step 5, 0.1 to 1 part by weight of fermented moringa extract, 0.1 to 1 part by weight of fermented extract of moringa, and 0.1 to 1 part by weight of kkujippong extract are additionally included in 100 parts by weight of the herbal tea, and the fermented moringa extract is added. For water, add 300 to 400 parts by weight of 80% (v/v) ethanol to 100 parts by weight of Moringa leaves, add 1 to 3 parts by weight of H. It is prepared by fermentation for 30 to 32 hours, and the fermented product of the lower age extract is 100 parts by weight of the lower age extract extracted at 65 to 70 ° C for 24 to 25 hours by adding 600 to 700 parts by weight of 70% (v / v) ethanol to 100 parts by weight It is prepared by adding 1 to 3 parts by weight of mixed bacteria to the part and fermenting at 15 to 20 ° C. for 14 to 15 hours. Including, the kkujippong extract is added to 800 to 900 parts by weight of water to 100 parts by weight of kkujippong fruit, extracted at 100 to 105 ° C. for 4 to 6 hours, and then concentrated in low temperature vacuum at 50 to 60 ° C. to prepare a 70 to 75 Brix kkujippong concentrate After that, it is prepared by heating at 70 ~ 75 ℃ for 25 ~ 30 minutes.

The manufacturing method of herbal tea for preventing and improving dementia according to the present invention has an excellent effect on improving dementia.

In addition, the manufacturing method of herbal tea for preventing and improving dementia according to the present invention has an advantage of excellent taste.

Hereinafter, the present invention will be described in detail.

First, a method for manufacturing herbal tea for preventing and improving dementia according to the present invention will be described.

The manufacturing method of herbal tea for preventing and improving dementia of the present invention,

After adding 60ℓ of water to 30kg of puffed rice and increasing it using a steamer at 1.2kg/cm2 at 110℃ for 30 minutes, 80g of Aspergillus Kawachii was added and cultured for 40 hours in a thermo-hygrostat at 26℃ to enter the country. manufacturing step (step 1);

Fermenting 4 kg of the entry, 6 kg of water, and 5 g of yeast at 25 to 30 ° C. for 6 days to prepare main hair (step 2);

10 kg of above hair, 50 kg of above seaweed, 70 kg of water, Angelica root 1200 g, Ginkgo ginseng root 1000 g, Ginkgo leaf 1000 g, Astragalus 800 g, Eucommia 700 g, Schisandra fruit 640 g, Wonji root 640 g, Iris root 640 g, Hawthorn fruit 640g, antler horn 640g, cnidium root 500g, fructo-oligosaccharide 500g, longan meat 400g, dansam root 390g, licorice 300g, and stevia extract 10g fermented at 22-23 ° C. for 6 months to obtain a first stock (step 3);

fermenting 130 kg of the first feed, 100 kg of puffed rice, 160 kg of water, and 150 g of purified enzyme at 15-16° C. for 3 days to obtain a second feed (step 4); and

Preparing herbal tea for preventing and improving dementia by heating the second injection at 100 to 105 ° C. for 30 to 40 minutes (step 5);

includes

In step 1, the expanded rice is mixed with 30 kg of non-glutinous rice and 30 kg of water, heated for 10 minutes in a pressure heater with an internal temperature of 100 ° C, dried in a vacuum dryer at 15 ° C and 120 Pa pressure, and then 100 to 150 mesh It is prepared by crushing

In the step 3, 10 kg of the main hair, 50 kg of the inflorescence, 70 kg of water, 1200 g of angelica root, 1000 g of ginko root, 1000 g of ginkgo leaf, 800 g of Astragalus 800 g, 700 g of Eucommia, 640 g of Schizandra fruit, 640 g of root, 640 g of iris root , Hawthorn fruit 640g, deer antlers 640g, Cnidium root 500g, fructooligosaccharide 500g, Yonganyuk fruit 400g, Dansam root 390g, licorice root 300g, and stevia extract 10g are fermented at 22-23°C for 6 months to obtain the first stock. .

The present invention ferments angelica root, ginseng root, ginkgo leaf, astragalus, Eucommia, Schisandra fruit, wonji root, calamus root, hawthorn fruit, antlers, cnidium root, longan yuk fruit, sweet ginseng root, and licorice for 6 months By doing this, the medicinal ingredients of Angelica root, ginseng root, ginkgo biloba leaf, Astragalus, Eucommia, Schisandra fruit, wonji root, calamus root, hawthorn fruit, antlers, cnidium root, longan yuk fruit, sweet ginseng root and licorice can be significantly eluted. There are advantages to being

Angelica is a perennial herbaceous plant belonging to the umbel family, and is mainly cultivated for medicinal purposes in Korea, Japan, and China. Angelica gigas Nakai produced in Korea, Angelica acutiloba Kitagawa produced in Japan, and Chinese donkey produced in China (Angelica sinensis Diels) are classified according to their origin, and their components and pharmacological effects is known to be different. Since ancient times, young angelica plants have been eaten as herbs, and the root has been used as a medicine for various diseases such as pain relief, anti-cancer, reduction of kidney toxicity, improvement of liver function, treatment of diabetic hypertension, and improvement of blood circulation.

The ginseng is a perennial shrub belonging to the Araliaceae genus Acanthopanax , better known as 'Siberian ginseng' in Russia and Europe, anti-fatigue, anti-stress, immune activation, anti-depression, anti-excitement, anti-excitement Various pharmacological effects such as diabetes and anticancer are recognized domestically and internationally.

The fact that the ginkgo leaf ( Ginkgo biloba L. ) has been used as a treatment for asthma and bronchitis for about 5,000 years has been described in the Chinese Pharmacopoeia, and its efficacy is still being evaluated. Recently, it is widely used in Asia and Europe as a treatment for peripheral circulatory disorders, cerebrovascular disorders and asthma in the elderly.

The Astragali Radix is a root of Astragalus membranaceus Bunge (leguminosae), which is used as a bogie that is used as it is or by removing the skin, which is widely used in oriental medicine for the purpose of suppressing perspiration, strengthening, strengthening, strengthening physical strength, and recovering from fatigue. is a drug. Cycloartane-type sapnin, isoflavonoid and polysaccharides have been reported as major functional components.

The Eucommia ulmoides oliver refers to a deciduous tree belonging to Eucommiaceae or a dried crude drug of its bark. Eucommia stems and leaves have been drunk as tea since ancient times, and contain a lot of vitamin C, and are effective in preventing heart disease, diabetes, and arteriosclerosis with the action of increasing adrenal function. Its stems and leaves have been consumed as herbal medicines useful for various diseases such as high blood pressure, stress, arthritis, and hangovers since ancient times, and recently, clinical experiments have gradually revealed the pharmacological mechanisms of various components contained in Eucommia. Accordingly, its value is being recognized again, and it is widely consumed as a health tea.

The Schizandra chinensis ( Schizandra chinensis ) is a fruit of a magnolia family plant, and is processed and used as herbal medicine material, tea or summer flower material, and starchy food and Schizandra chinensis using its pigment. Schisandra chinensis contains a large amount of organic acids and anthocyanin pigments, and is known to have anti-aging activity, immunomodulatory activity, and antibacterial activity.

The base paper (Polygala tenuifolia) is a plant belonging to the tree without patients.

The seokchangpo is a perennial herb belonging to Araceae and is native to Korea, China, and Japan, and is native to the central and southern regions of Korea. Seokchangpo is a plant that grows in mountain valleys and has a rhizome that grows sideways and has a unique scent along with the stem on the ground. Seokchangpo is characterized by narrower leaves, shorter length, and thin roots than general irises that grow along ponds or ditches. In addition, other names for seokchangpo include sugeomcho, demand, changbon, changyang, changcho, iris, and gujeolchangpo.

The hawthorn (Crataegus pinnatifida Bunge) is a deciduous broad-leaved small tree of the dicotyledonous rose order Rosaceae. The tree is 3-6 m high, the bark is grayish, the branches have thorns, the leaves are alternate, close to egg shape, 6-8 cm long, 5-6 cm wide, the edges are split like feathers, and the lower part is deeply split. Hairs grow on both veins, irregular sawtooth on the edge, petiole is 2-6 cm long, white flowers bloom in May, hang on corymbs, petals are round, 5 each with calyx pieces. There are 20 stamens, 3-5 styles, anthers are red, and fruits are pomes, round with white spots, about 1.5 cm in diameter, and ripen in red in September-October. Distributed in Korea, China, Siberia, etc.

The antler means that ossification has progressed remarkably because the harvesting time of the antler has been delayed.

The Cnidii Rhizoma is a medicinal resource plant using the rhizome of Ligusticum chuanxiong Hort. or Cnidium officinale Makino, and is a perennial herb belonging to the family Umbelliferae . The main components include essential oil components such as cnidilide, ligustilide, butylidenephthalide, and senkyunolide, ferulic acid, and chlorogenic acid. acid) and the like are known. Cnidium is known for its pharmacological actions such as antispasmodic action, sedation action, blood pressure lowering action, vasodilation action, antibacterial action, and antifungal action. .

The fructooligosaccharide has a very similar sweetness to sugar, has a sweetness of 60% of sugar, and has health functionalities, so it is attracting attention as a sugar substitute. Fructooligosaccharide refers to a mixture of components in which 1 to 3 fructose are bonded to sugar using fructose transferase as a substrate. Fructooligosaccharides help to proliferate beneficial bacteria in the intestine and inhibit harmful bacteria, and have an effect on intestinal function that helps smooth bowel movements.

The longan yuk ( Lonaganae Arillus ) is an evergreen tree of Sapindaceae and refers to the flesh of the longan fruit. In the Korean Pharmacopoeia, Yongan yuk is a longitudinally ruptured irregular slice of longan husk, usually several sticking together, 2 to 4 cm long, 1 to 2 cm wide, and 2 to 4 mm thick, with a dark reddish brown outer surface. It is defined as ~blackish-brown translucent, wrinkled and uneven on one side, shiny and vertically wrinkled on the other side, soft and viscous in quality, slightly characteristic odor, and sweet in taste.

The Dansam (Salvia miltiorrhiza BUNGE) is a medicinal herb widely used in oriental medicine from ancient times, and is a perennial plant belonging to the Lamiaceae (Labiatae), a dicotyledonous plant, and its origin is China. Dansam removes the beard roots and uses the sun-dried roots for medicinal purposes. It is collected from early November to early March of the following year. Components contained in the root of Danshen include tanshinone I, tanshinone ⅡA, tanshinone IIB, dihydrotanshinone, and methyl tanshinonate. , methylene tanshinquinone, beta-sitosterol, hydroxytanshinone, neotanshinone A B C, salviol, isotansinone I ( isotanshinone I), isotanshinone II, isocryptotanshinone, miltirone, tanshinol I, tanshinol II and vitamin E ) have been reported.

The licorice ( Glycyrrhiza uralensis ) is a perennial plant belonging to the leguminous family and is native to or cultivated in northern China, Siberia, southern Italy, Manchuria, Mongolia and the like. Licorice is one of the herbs used as an antitussive and enters as a component to reduce toxicity in all herbal prescriptions. In Europe, it is also used to sweeten cigarettes, gum, and candy. According to recent research results, it has been confirmed that licorice alleviates oxidative damage in the kidneys and has the effect of protecting liver cells from damage by cadmium.

The stevia is a perennial root plant belonging to the Asteraceae family, and the stevia leaf contains 6 to 7% of stevioside as a main sweetening component compared to the weight of the outpost. The sweetness of stevioside is 250 times that of sugar, and is used as a non-carcinogenic or non-caloric substitute sweetener.

The stevia extract was immersed in 10 kg of stevia leaves in 20 L of seaweed water for 12 hours, dried and pulverized, and then the pulverized product was put into a reactor of a supercritical extractor, and the reactor was rotated while injecting CO ₂ gas, When the pressure is maintained at 60 atm, the extract obtained by circulating CO ₂ is filtered, freeze-dried, and then powdered.

The seaweed water is prepared by adding 1,000 parts by weight of goji berry extract to 100 parts by weight of a mixture of 80% by weight of seaweed, 15% by weight of plum, and 5% by weight of Schisandra chinensis, heated at 100 to 105 ° C. for 4 to 6 hours, and then filtered.

The goji berry extract was prepared by adding 300 to 400 parts by weight of water to 100 parts by weight of goji berry, heating at 95 to 105 ° C. for 1 to 2 hours, and then filtering.

Step 4 is a step of obtaining a second feed by fermenting 130 kg of the first feed, 100 kg of puffed rice, 160 kg of water, and 150 g of purified enzyme at 15-16 ° C for 3 days.

The expanded rice prepared in step 1 is used as the expanded rice.

After the step 4, 1 to 3 parts by weight of a sawtooth cap extract, 1 to 3 parts by weight of a rowan extract, and 1 to 3 parts by weight of a silver flower extract may be additionally included in 100 parts by weight of the second injection.

There is an advantage in that the effect of improving dementia can be further improved by additionally including a sawtooth capricorn extract, a rowan extract, and a gold silver flower extract in the second injection.

The cap and cap extract is prepared by putting 100 g of cap and cap in 2 liters of 30% (v/v) ethanol aqueous solution and extracting at 25° C. for 24 hours.

The sawtooth cap ( Sargassum serratifolium ) is a plant that grows from the intertidal zone to the lunch zone and is a perennial large brown algae of 1 to 4 m. The root is 4-5cm in diameter, conical, like rubber, with annual growth rings, and the stem is short, circumferential, divided into many central branches, and flattened. In addition, both edges of the stem are thin, vertically raised on one side like a midrib, and short branches are produced at the edge. There are leaves or thorn-like projections. In particular, it is known to grow in the southern coast of Korea and Jeju, and is known to have functions for lowering lipids, lowering blood pressure, and releasing radioactive isotopes.

The rowan extract is prepared by adding 100 g of rowan tree to 2 liters of 50% (v/v) ethanol aqueous solution and extracting at 35° C. for 24 hours.

The rowan tree (Sorbus commixta) is a deciduous tree belonging to the genus Rosaceae Rowan, which grows well in mountains at an altitude of 500m-1000m and is a tree distributed in Japan, China, Europe and the United States. The drug name is known as Jeonggong in Chinese characters, and is known to be effective in phlegm, cough, lowering blood pressure, and diuretic action. The fruit can be used as a tea or eaten raw.

The gold and silver flower extract is prepared by putting 100 g of gold and silver flowers in 2 liters of 70% (v/v) ethanol aqueous solution and extracting at 40° C. for 24 hours.

The gold silver flower ( Lonicerae flos ) is a flower bud of Lonicera japonica, a creeping shrub Lonicera japonica , which is a Caprifoliacear plant, and is used in oriental medicine or privately for diuresis, stomachache, arthritis, purulent dermatitis, and bronchitis. Research on the components of gold and silver flowers includes tannin, inositol, sterol, chlorogenic acid, isochlorogenic acid, apigenin, quercetin, etc. this is known Reports on the activity of gold silver flowers include anti-inflammatory effect, selective inhibitory effect on HIV-1 RT, inactivation effect of phospholipase A2, treatment of honeysukcle contact dermatitis, treatment of pediatric bronchopneumonia, platelet activity and Endothelial cell damage inhibitory effect, viral myocarditis treatment effect, modified cell-mediated immunity effect, etc. are known.

Step 5 is a step of preparing herbal tea by heating the second injection at 100 to 105 ° C. for 30 to 40 minutes.

By heating the second injection at 100 to 105 ° C. for 30 to 40 minutes, the alcohol component can be evaporated and liquid herbal tea can be obtained.

After the step 5, 0.1 to 1 part by weight of fermented moringa extract, 0.1 to 1 part by weight of fermented extract of moringa, and 0.1 to 1 part by weight of kkujippong extract may be additionally included in 100 parts by weight of the herbal tea.

There is an advantage in that the taste of the herbal tea can be further improved by additionally including the fermented Moringa extract, the fermented extract, and the fermented kkujippong extract in the herbal tea.

The fermented Moringa extract is added with 300 to 400 parts by weight of 80% (v / v) ethanol to 100 parts by weight of Moringa leaves, and 1 to 3 parts by weight of H. It is prepared by fermentation at 15-20℃ for 30-32 hours.

Although Moringa is a small tree native to India, it is cultivated anywhere in the world and is naturalized and wild in many areas where Moringa trees are widely used. There are 13 species of Moringa trees belonging to the Moringa family, with Moringa oleifera being the most widely known. Moringa oleifera is a shrub 4 to 8 meters tall that spreads like an umbrella. The leaves are deciduous with a length of 30 to 70 cm, the flowers are white and fragrant, the fruits are green, and the length is 30 to 40 cm with long leathery and hanging triangular pods. It is a kind of multi-purpose tree native to the foot of a mountain and cultivated in all tropical regions. Moringa (Moringa oleifera) is a plant native to Southeast Asia, etc., and is called a miracle plant because it contains a large amount of nutrients, and is known to have various effects such as anti-diabetic, anti-cancer, and anti-allergy.

The Hwanggukgyun is a kind of bacteria that has been attached to some of the native bacteria in the production of Korean traditional meju, but has been used as a pure separation in the production of soybean paste, soy sauce, and rice wine in Japan.

The jeoryeong extract fermented product is added to 100 parts by weight of 70% (v / v) ethanol, 600 to 700 parts by weight of 70% (v / v) ethanol, and 1 to 3 parts by weight of mixed bacteria added to 100 parts by weight of jeoryeong extract extracted at 65 to 70 ° C for 24 to 25 hours. and fermented for 14 to 15 hours at 15 to 20 ° C.

The mixed bacteria include 60 to 70% by weight of lactic acid bacteria, 20 to 30% by weight of Honggukgyun, and 5 to 15% by weight of Bacillus subtilis.

The low age ( Polyporus umbellatus ) is also called by names such as Ju-ryeong, Shi-ryeong, Jeo-si-ryeong, Geo-do, Huiryeong, Gajeosi, etc., and is classified as a mushroom belonging to the basidiomycete Minoreum Mushroom Tree Holey Mushroom Family, especially in broad-leaved forests in autumn It is parasitic on the roots of alder, oak, maple and oak trees, and is sweet and bitter. It is mainly distributed in Korea, Japan, Europe, China, and the United States, and the stem is split several times at the base, and the cap blooms at the end of each branch. The height is 10-20 cm, and the diameter is 10-30 cm. The sclerotium is an irregular mass, and there are many similar to ginger, and the surface shows a peculiar shape and is yellowish white or weasel color. It resembles pig stool, hence the name 'Jeoryeong'. The fruiting body becomes a complicatedly branched stalk and cap. Irregular long lumps or lumps close to round, the size is uneven, and the long ones are usually bent or cracked like ginger, 5 to 25 cm long. The surface is black, wrinkled in black brown, or has bumpy projections. It is light and tough, and the cross section is milky white or yellowish white. Jeoryeong has the effect of facilitating water metabolism, and is used when you cannot urinate well or have swelling throughout the body. .

The lactic acid bacteria are Lactobacillus delbrueckii , Lactobacillus bulgaricus , Lactobacillus casei , Lactobacillus brevis , Lactobacillus acidophilus , Pedi Ococus pentosaceus ( Pediococcus pentosaceus ), Pediococcus cerevisiae ( Pediococcus cerevisiae ), Lactococcus lactis ( Lactococcus lactis ), Leuconostoc citreum ( Leuconostoc citreum ), Leconostoc mesenteroids ( Leuconostoc mesenteroides ), Any one selected from the group consisting of Bifidobacterium bifidum and Lactobacillus rhamnosus may be used.

The honggukgyun is a red filamentous fungus belonging to the genus Monascus, and produces dark red pigments and monacolin K as various useful metabolites in the process of fermenting grains such as rice. This fungus has been used for a long time in various parts of East Asia, mainly in China, as a natural food coloring agent, processed product, and material for promoting digestion and improving blood flow. Mebinolin, a secondary metabolite produced by Honggukgyun, strongly inhibits HMG-CoA (3-hydroxy-methyl-3-glutaryl-coenzyme) reductase, a cholesterol biosynthetic enzyme, to reduce blood lipid concentration and inhibit cholesterol synthesis or It has various functions such as antifungal, inhibition of blood sugar rise, blood pressure control, anti-obesity, and anti-cancer. In addition, honggukgyun produces red pigments (rubropuntain, monascorubin), yellow pigments (monascin, ankaflavin), purple pigments (rubropunctamine, monascorubramine), and the like, and these pigment substances have antibacterial and anticancer effects.

The honggukgyun is Monascus pilosus, Monascus rubber, Monascus ruber , Monascus purpureus , Monascus kaoliang , Monascus barykery and Monas Any one selected from the group consisting of Monascus anka may be used.

The Bacillus subtilis is Bacillus subtilis ( B. subtilis ), Bacillus lichneformis ( B. lichneformis ), Bacillus megaterium ( B. megaterium ), Bacillus amyloliquefaciens ( B. amyloliquefaciens ), Bacillus natto ( B. natto ), Bacillus anthracis ( B.antharcis ), Bacillus lentus ( B.lentus ), Bacillus furmirus ( B.pumilus ), Bacillus thelingsiensis ( B.thuringiensis ), Bacillus albei ( B.alvei) ), Bacillus azotopic Sans ( B.azotofixans ), Bacillus Macerans ( B.macerans ), Bacillus polymyxa ( B.polymyxa ), Bacillus papilliae ( B.popilliae ), Bacillus coagulans ( B.coagulans ), Bacillus Stearodermophilus ( B.stearothermophilus ), Bacillus Pasteurii ( B.pasteurii ), Bacillus paricus ( B.sphaericus ) and Bacillus Pastidiosus ( B.fastidiosus ) Any one selected from the group consisting of can be used.

The kkujippong cheong is added to 800 to 900 parts by weight of water to 100 parts by weight of kkujippong fruit, extracted at 100 to 105 ° C for 4 to 6 hours, and then concentrated in low temperature vacuum at 50 to 60 ° C. After preparing a concentrate of 70 to 75 Brix, 70 It is prepared by heating at ~75°C for 25-30 minutes.

The kuji mulberry tree is a part of the Morus family, and the fruit that grows naturally in the cudra mulberry tree is used in many products such as beverages, jam, red pepper paste, etc., and the cudra mulberry fruit contains pharmacological substances such as GABA, rutin, flavonoids, mortin asaparaganic acid, In particular, GABA is a neurotransmitter that can have good effects on anxiety, depression, insomnia, and memory improvement, and rutin strengthens capillaries and is known to have a good effect on diabetes and blood pressure.

The manufacturing method of herbal tea for preventing and improving dementia according to the present invention has an excellent effect on improving dementia.

In addition, the manufacturing method of herbal tea for preventing and improving dementia according to the present invention has the advantage of having no side effects.

Hereinafter, the configuration and effects of the present invention will be described in more detail through examples. These examples are only for illustrating the present invention, but the scope of the present invention is not limited by these examples.

30 kg of non-glutinous rice and 30 kg of water were mixed, heated for 10 minutes in a pressure heater with an internal temperature of 100 ° C, dried in a vacuum dryer at 15 ° C and 120 Pa pressure, and then pulverized into 100 mesh to prepare puffed rice. After adding 60ℓ of water to 30kg of the puffed rice and increasing it using a steamer at 1.2kg/cm2 at 110 ° C for 30 minutes, 80 g of Aspergillus Kawachii was added and cultured for 40 hours in a thermo-hygrostat at 26 ° C. was manufactured. 4 kg of the above entry, 6 kg of water, and 5 g of yeast were fermented at 25 to 30 ° C. for 6 days to prepare stock hair. 10 kg of above hair, 50 kg of above seaweed, 70 kg of water, Angelica root 1200 g, Ginkgo ginseng root 1000 g, Ginkgo leaf 1000 g, Astragalus 800 g, Eucommia 700 g, Schisandra fruit 640 g, Wonji root 640 g, Iris root 640 g, Hawthorn fruit 640g, antler horn 640g, cnidium root 500g, fructooligosaccharide 500g, longan meat 400g, danseng root 390g, licorice 300g, and stevia extract 10g were fermented at 23° C. for 6 months to obtain a first insert. The stevia extract was immersed in 10 kg of stevia leaves in 20 L of seaweed water for 12 hours, dried and pulverized, and then the pulverized product was put into a reactor of a supercritical extractor, and the reactor was rotated while injecting CO ₂ gas, When the pressure was maintained at 60 atm, the extract obtained by circulating CO ₂ was filtered, freeze-dried, and then powdered. The glasswort water was prepared by adding 1,000 parts by weight of goji berry extract to 100 parts by weight of a mixture of 80% by weight of seaweed, 15% by weight of plum, and 5% by weight of Schisandra chinensis, heated at 100 to 105 ° C. for 4 to 6 hours, and then filtered. The goji berry extract was prepared by adding 300 to 400 parts by weight of water to 100 parts by weight of goji berry, heating at 95 to 105 ° C. for 1 to 2 hours, and then filtering. 130 kg of the first feed, 100 kg of puffed rice, 160 kg of water, and 150 g of purified enzyme were fermented at 15 ° C. for 3 days to prepare a second feed. The second injection was heated at 100 ° C. for 40 minutes to prepare herbal tea for preventing and improving dementia.

In Example 1, except for additionally including 3 parts by weight of sawtooth extract, 3 parts by weight of mountain ash extract, and 3 parts by weight of silver flower extract in 100 parts by weight of the second injection, 100 parts by weight of the second injection, the rest was the same. Herbal tea for prevention and improvement was prepared. The cap-tooth extract was prepared by adding 100 g of cap-tooth cap to 2 liters of 30% (v/v) ethanol aqueous solution and extracting at 25° C. for 24 hours. The rowan extract was prepared by adding 100 g of rowan tree to 2 liters of 50% (v/v) ethanol aqueous solution and extracting at 35° C. for 24 hours. The gold and silver flower extract was prepared by adding 2 liters of 70% (v/v) ethanol solution to 100 g of gold and silver flowers and extracting at 40° C. for 24 hours.

[Comparative Example 1]

After adding 500 ml of 70% ethanol to 200 g of pulverized Phellinus Phellinus, extraction was performed at room temperature for 2 hours using an ultrasonic crusher, followed by filtration and drying under reduced pressure to obtain 15.7 g of crude extract powder of Phellinus Phellinus, which is a 70% ethanol-soluble extract.

[Experimental Example 1]

The herbal tea obtained in Examples 1 and 2 and the Phellinus Phellinus extract of Comparative Example 1 were measured for acetylcholinesterase activity inhibitory effect, and the results are shown in Table 1.

In the acetylcholinesterase inhibitory activity test, the enzymatic activity was determined according to Ellman's method by hydrolyzing the substrate acetylthiocholine iodide by acetylcholinesterase to release thiocholine from DTNB. (Dithionitrobenzoic acid) and the thioanion of nitrobenzoic acid and the dithio compound produced by reaction were detected with 405 nm UV to measure the enzyme activity, and tacrine (1,2,3) known as an acetylcholinesterase inhibitor ,4-tetrahydro-9-acridinamine) was compared with the inhibitory activity level to evaluate the level of inhibitory activity.

A DMSO solution containing the herbal tea of Examples 1 and 2 and the Phellinus linteus extract of Comparative Example 1 at a concentration of 50 mg/mL, respectively, and a DMSO solution containing tacrine (SIGMA-ALDRICH) at a concentration of 2 mg/mL as a control group, As a control, 100% DMSO was diluted with phosphate buffer (0.1M, pH 8.0) to a concentration of 250 (μg/ml), and 10 μl of each sample was taken and placed in a test tube with 50 mM Dithiobis-nitrobenzoic acid solution. 5 μl, 132.5 μl of phosphate buffer (0.1M, pH 8.0) and 2.5 μl (SIGMA-ALDRICH) of 50 unit/ml acetylcholine esterase enzyme solution were added and reacted in an incubator at 25 ° C for 5 minutes, and then the absorbance at 405 nm was measured using a spectrophotometer was measured, 50 μl of 0.1 mM acetylthiocholine iodide solution was added, reacted in a 25° C. incubator for 3 minutes, and absorbance was measured at 405 nm. The degree of inhibition of enzyme activity was calculated through the following equation.

[mathematical expression]

Activity inhibition (%) = (A / B) x 100%

A: Difference between absorbance before and after reaction with acetylthiocholine iodine in each experimental group including extract

B: Difference between absorbance before and after reaction with acetylthiocholine iodine in the control group

division Acetylcholinesterase inhibitory activity (%) Example 1 96.1 Example 2 98.7 Comparative Example 1 91.5

As shown in Table 1, it can be confirmed that the herbal teas of Examples 1 and 2 exhibit superior acetylcholinesterase inhibitory activity compared to the Sanghwang mushroom extract of Comparative Example 1.

In Example 1, except that 100 parts by weight of the herbal tea additionally included 1 part by weight of fermented moringa extract, 1 part by weight of fermented fermented extract, and 1 part by weight of kkujippong extract, the rest was the same to prevent and improve dementia. tea was made. The fermented Moringa extract was added with 300 parts by weight of 80% (v/v) ethanol to 100 parts by weight of Moringa leaves, added 3 parts by weight of Hwanggukgyun to 100 parts by weight of Moringa leaf extract ultrasonically extracted for 16 hours, and stirred at 20 ° C for 30 hours. It was prepared by fermentation. The jeoryeong extract fermented product was added with 600 parts by weight of 70% (v / v) ethanol to 100 parts by weight of jeoryeong, and 3 parts by weight of the mixed bacteria was added to 100 parts by weight of jeoryeong extract extracted at 70 ° C for 24 hours and fermented at 20 ° C for 14 hours. It was prepared by The mixed bacteria was prepared by mixing 65% by weight of lactic acid bacteria, 25% by weight of Honggukgyun, and 10% by weight of Bacillus subtilis. The kkujippong extract was prepared by adding 900 parts by weight of water to 100 parts by weight of kkujippong fruit, extracting at 100 ° C. for 4 hours, and then concentrating in low temperature vacuum at 50 ° C. to prepare a 70Brix kkujippong concentrate, followed by heating at 75 ° C. for 30 minutes.

[Comparative Example 2]

1,300 ml of distilled water was added to herbal medicines mixed with ginseng, cornus oil, quince, and Schisandra chinensis in a weight ratio of 2:5:5:3, heated in a hot water extractor for 3 hours, and the resulting extract was filtered once and concentrated with a vacuum distillation device, After this, the completely dried herbal extract was stored in a deep-freezer freezer (-84 ° C) using a freeze dryer, and then diluted to prepare a health drink for preventing dementia using herbal medicine.

[Experimental Example 2]

The oriental tea prepared in Examples 1 and 3 and the beverage prepared in Comparative Example 2 were subjected to sensory tests such as taste, aroma, and overall acceptability by a sensory test agent. The average of the measured results is shown in Table 2. The sensory test was measured using a 9-point scale method by 30 sensory test personnel with more than 2 years of sensory test experience.

taste incense overall sign Example 1 8.3 8.5 8.4 Example 3 8.5 8.7 8.6 Comparative Example 2 7.2 7.4 7.3

As can be seen from Table 2, compared to the beverage of Comparative Example 2, the herbal teas of Examples 1 and 3 prepared according to the present invention showed higher scores in all items of the sensory test.

Claims (5)

After adding 60ℓ of water to 30kg of puffed rice and increasing it using a steamer at 1.2kg/cm2 at 110℃ for 30 minutes, 80g of Aspergillus Kawachii was added and cultured for 40 hours in a thermo-hygrostat at 26℃ to enter the country. manufacturing step (step 1);
Fermenting 4 kg of the entry, 6 kg of water, and 5 g of yeast at 25 to 30 ° C. for 6 days to prepare main hair (step 2);
10 kg of above hair, 50 kg of above seaweed, 70 kg of water, Angelica root 1200 g, Ginkgo ginseng root 1000 g, Ginkgo leaf 1000 g, Astragalus 800 g, Eucommia 700 g, Schisandra fruit 640 g, Wonji root 640 g, Iris root 640 g, Hawthorn fruit 640g, antler horn 640g, cnidium root 500g, fructo-oligosaccharide 500g, longan meat 400g, dansam root 390g, licorice 300g, and stevia extract 10g fermented at 22-23 ° C. for 6 months to obtain a first stock (step 3);
fermenting 130 kg of the first feed, 100 kg of puffed rice, 160 kg of water, and 150 g of purified enzyme at 15-16° C. for 3 days to obtain a second feed (step 4); and
Preparing herbal tea for preventing and improving dementia by heating the second injection at 100 to 105 ° C. for 30 to 40 minutes (step 5);
including,
Manufacturing method of herbal tea for prevention and improvement of dementia.
The method of claim 1, wherein in step 1,
The expanded rice is prepared by mixing 30 kg of non-glutinous rice and 30 kg of water, heating for 10 minutes in a pressure heater with an internal temperature of 100 ° C, drying in a vacuum dryer at 15 ° C and a pressure of 120 Pa, and then pulverizing into 100 to 150 mesh ,
Manufacturing method of herbal tea for prevention and improvement of dementia.
The method of claim 1, wherein in step 3,
The stevia extract was immersed in 10 kg of stevia leaves in 20 L of seaweed water for 12 hours, dried and pulverized, and then the pulverized product was put into a reactor of a supercritical extractor, and the reactor was rotated while injecting CO ₂ gas, When the pressure is maintained at 60 atmospheres, the extract obtained by circulating CO ₂ is filtered, freeze-dried, and then powdered to prepare,
The seaweed water is prepared by adding 1,000 parts by weight of goji berry extract to 100 parts by weight of a mixture of 80% by weight of seaweed, 15% by weight of plum, and 5% by weight of Schizandra chinensis, heated at 100 to 105 ° C. for 4 to 6 hours, and then filtered.
The goji berry extract is prepared by adding 300 to 400 parts by weight of water to 100 parts by weight of goji berry, heating at 95 to 105 ° C. for 1 to 2 hours, and then filtering.
Manufacturing method of herbal tea for prevention and improvement of dementia.
According to claim 1,
After the step 4, 1 to 3 parts by weight of a sawtooth cap extract, 1 to 3 parts by weight of a rowan extract, and 1 to 3 parts by weight of a silver flower extract are additionally included in 100 parts by weight of the second injection,
The cap and cap extract is prepared by adding 100 g of cap and cap in 2 liters of 30% (v/v) ethanol aqueous solution and extracting at 25° C. for 24 hours,
The rowan extract is prepared by adding 100 g of rowan tree to 2 liters of 50% (v/v) ethanol aqueous solution and extracting at 35° C. for 24 hours,
The gold and silver flower extract is prepared by adding 2 liters of 70% (v / v) ethanol aqueous solution to 100 g of gold and silver flowers and extracting at 40 ° C. for 24 hours.
Manufacturing method of herbal tea for prevention and improvement of dementia.
According to claim 1,
After step 5, 0.1 to 1 part by weight of fermented moringa extract, 0.1 to 1 part by weight of fermented extract of moringa, and 0.1 to 1 part by weight of kkujippong extract are additionally included in 100 parts by weight of the herbal tea,
The fermented Moringa extract is added with 300 to 400 parts by weight of 80% (v / v) ethanol to 100 parts by weight of Moringa leaves, and 1 to 3 parts by weight of H. It is prepared by fermentation at 15 to 20 ° C for 30 to 32 hours,
The jeoryeong extract fermented product is added to 100 parts by weight of 70% (v / v) ethanol, 600 to 700 parts by weight of 70% (v / v) ethanol, and 1 to 3 parts by weight of mixed bacteria added to 100 parts by weight of jeoryeong extract extracted at 65 to 70 ° C for 24 to 25 hours. and fermented at 15 to 20 ° C for 14 to 15 hours,
The mixed bacteria include 60 to 70% by weight of lactic acid bacteria, 20 to 30% by weight of Honggukgyun, and 5 to 15% by weight of Bacillus subtilis,
The kkujippong cheong is added to 800 to 900 parts by weight of water to 100 parts by weight of kkujippong fruit, extracted at 100 to 105 ° C for 4 to 6 hours, and then concentrated in low temperature vacuum at 50 to 60 ° C. After preparing a concentrate of 70 to 75 Brix, 70 Prepared by heating at ~75 ° C for 25 to 30 minutes,
Manufacturing method of herbal tea for prevention and improvement of dementia.