KR20220157515A - Liv1-adc와 화학요법제를 사용한 병용 요법 - Google Patents

Liv1-adc와 화학요법제를 사용한 병용 요법 Download PDF

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KR20220157515A
KR20220157515A KR1020227039721A KR20227039721A KR20220157515A KR 20220157515 A KR20220157515 A KR 20220157515A KR 1020227039721 A KR1020227039721 A KR 1020227039721A KR 20227039721 A KR20227039721 A KR 20227039721A KR 20220157515 A KR20220157515 A KR 20220157515A
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liv
administered
pharmaceutical composition
adc
subject
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Korean (ko)
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장고 수스만
푸 리
아나 코스틱
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씨젠 인크.
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Priority to KR1020237041743A priority Critical patent/KR20230169462A/ko
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6855Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015Breast
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
KR1020227039721A 2016-03-15 2017-03-15 Liv1-adc와 화학요법제를 사용한 병용 요법 Ceased KR20220157515A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237041743A KR20230169462A (ko) 2016-03-15 2017-03-15 Liv1-adc와 체크포인트 억제제를 사용한 병용 요법

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201662308639P 2016-03-15 2016-03-15
US62/308,639 2016-03-15
US201662317792P 2016-04-04 2016-04-04
US62/317,792 2016-04-04
US201662367510P 2016-07-27 2016-07-27
US62/367,510 2016-07-27
KR1020187028273A KR20180121571A (ko) 2016-03-15 2017-03-15 Liv1-adc와 화학요법제를 사용한 병용 요법
PCT/US2017/022541 WO2017161007A1 (en) 2016-03-15 2017-03-15 Combination therapy using a liv1-adc and a chemotherapeutic

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187028273A Division KR20180121571A (ko) 2016-03-15 2017-03-15 Liv1-adc와 화학요법제를 사용한 병용 요법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020237041743A Division KR20230169462A (ko) 2016-03-15 2017-03-15 Liv1-adc와 체크포인트 억제제를 사용한 병용 요법

Publications (1)

Publication Number Publication Date
KR20220157515A true KR20220157515A (ko) 2022-11-29

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Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020237041743A Withdrawn KR20230169462A (ko) 2016-03-15 2017-03-15 Liv1-adc와 체크포인트 억제제를 사용한 병용 요법
KR1020227039721A Ceased KR20220157515A (ko) 2016-03-15 2017-03-15 Liv1-adc와 화학요법제를 사용한 병용 요법
KR1020187028273A Ceased KR20180121571A (ko) 2016-03-15 2017-03-15 Liv1-adc와 화학요법제를 사용한 병용 요법

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KR1020237041743A Withdrawn KR20230169462A (ko) 2016-03-15 2017-03-15 Liv1-adc와 체크포인트 억제제를 사용한 병용 요법

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KR1020187028273A Ceased KR20180121571A (ko) 2016-03-15 2017-03-15 Liv1-adc와 화학요법제를 사용한 병용 요법

Country Status (14)

Country Link
US (2) US11325980B2 (enExample)
EP (1) EP3429626A4 (enExample)
JP (3) JP2019508433A (enExample)
KR (3) KR20230169462A (enExample)
CN (1) CN108697801A (enExample)
AU (2) AU2017235545A1 (enExample)
BR (1) BR112018068129A2 (enExample)
CA (1) CA3016485A1 (enExample)
EA (1) EA201891968A1 (enExample)
IL (1) IL261505A (enExample)
MA (1) MA45324A (enExample)
MX (2) MX2018010847A (enExample)
SG (2) SG11201807526SA (enExample)
WO (1) WO2017161007A1 (enExample)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
CA2819038C (en) 2010-12-06 2023-10-17 Seattle Genetics, Inc. Humanized antibodies to liv-1 and use of same to treat cancer
US20200283540A1 (en) * 2017-12-01 2020-09-10 Seattle Genetics, Inc. Humanized anti-liv1 antibodies for the treatment of breast cancer
JP7471289B2 (ja) * 2018-11-07 2024-04-19 クリスパー セラピューティクス アクチェンゲゼルシャフト 抗liv1免疫細胞癌療法
CA3164124A1 (en) 2019-12-09 2021-06-17 Seagen Inc. Combination therapy with liv1-adc and pd-1 antagonist
AU2021349385A1 (en) * 2020-09-28 2023-05-25 Seagen Inc. Humanized anti-liv1 antibodies for the treatment of cancer
US12036286B2 (en) 2021-03-18 2024-07-16 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
WO2024188339A1 (zh) * 2023-03-15 2024-09-19 浙江博锐生物制药有限公司 抗liv-1抗体和抗liv-1抗体药物偶联物及其药物用途
WO2025162207A1 (zh) * 2024-01-31 2025-08-07 上海复宏汉霖生物技术股份有限公司 抗liv1抗体及使用方法

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