KR20220149585A - Jak 억제제 화합물의 결정성 수화물 - Google Patents

Jak 억제제 화합물의 결정성 수화물 Download PDF

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Publication number
KR20220149585A
KR20220149585A KR1020227034088A KR20227034088A KR20220149585A KR 20220149585 A KR20220149585 A KR 20220149585A KR 1020227034088 A KR1020227034088 A KR 1020227034088A KR 20227034088 A KR20227034088 A KR 20227034088A KR 20220149585 A KR20220149585 A KR 20220149585A
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South Korea
Prior art keywords
crystalline hydrate
lung
pneumonia
disease
compound
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English (en)
Korean (ko)
Inventor
진 티모시 파스
Original Assignee
세라밴스 바이오파마 알앤디 아이피, 엘엘씨
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Publication of KR20220149585A publication Critical patent/KR20220149585A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020227034088A 2020-03-02 2021-03-01 Jak 억제제 화합물의 결정성 수화물 Pending KR20220149585A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062983931P 2020-03-02 2020-03-02
US62/983,931 2020-03-02
PCT/US2021/070207 WO2021178991A1 (en) 2020-03-02 2021-03-01 Crystalline hydrate of a jak inhibitor compound

Publications (1)

Publication Number Publication Date
KR20220149585A true KR20220149585A (ko) 2022-11-08

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KR1020227034088A Pending KR20220149585A (ko) 2020-03-02 2021-03-01 Jak 억제제 화합물의 결정성 수화물

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US (2) US11702415B2 (enExample)
EP (1) EP4114836B1 (enExample)
JP (1) JP7681613B2 (enExample)
KR (1) KR20220149585A (enExample)
CN (1) CN115190878B (enExample)
AR (1) AR121483A1 (enExample)
AU (1) AU2021232100A1 (enExample)
BR (1) BR112022017398A2 (enExample)
CA (1) CA3172338A1 (enExample)
CL (1) CL2022002368A1 (enExample)
CO (1) CO2022012476A2 (enExample)
IL (1) IL295613A (enExample)
MX (1) MX2022010795A (enExample)
PH (1) PH12022552261A1 (enExample)
WO (1) WO2021178991A1 (enExample)
ZA (1) ZA202209617B (enExample)

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KR20260019479A (ko) 2023-05-04 2026-02-10 레볼루션 메디슨즈, 인크. Ras 관련 질환 또는 장애를 위한 병용 요법
CN121889155A (zh) 2023-08-07 2026-04-17 锐新医药公司 用于治疗ras蛋白相关疾病或病症的rmc-6291
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
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US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
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CN119438457B (zh) * 2024-12-18 2025-12-02 成都迈科康生物科技有限公司 一种测定脂质体佐剂中有关物质的方法及其应用
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US11702415B2 (en) 2023-07-18
PH12022552261A1 (en) 2023-11-13
EP4114836C0 (en) 2025-01-08
US20210269437A1 (en) 2021-09-02
AU2021232100A1 (en) 2022-10-20
US20240025897A1 (en) 2024-01-25
TW202144343A (zh) 2021-12-01
EP4114836A1 (en) 2023-01-11
AR121483A1 (es) 2022-06-08
CA3172338A1 (en) 2021-09-10
EP4114836B1 (en) 2025-01-08
CN115190878A (zh) 2022-10-14
WO2021178991A1 (en) 2021-09-10
JP7681613B2 (ja) 2025-05-22
MX2022010795A (es) 2022-11-30
CN115190878B (zh) 2024-10-29
US12122773B2 (en) 2024-10-22
IL295613A (en) 2022-10-01
CO2022012476A2 (es) 2022-09-20
CL2022002368A1 (es) 2023-04-21
BR112022017398A2 (pt) 2022-10-18
JP2023516640A (ja) 2023-04-20
ZA202209617B (en) 2023-04-26

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