KR20220129026A - 아밀로이드 제거를 위한 키메라 항원 수용체 - Google Patents

아밀로이드 제거를 위한 키메라 항원 수용체 Download PDF

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KR20220129026A
KR20220129026A KR1020227027772A KR20227027772A KR20220129026A KR 20220129026 A KR20220129026 A KR 20220129026A KR 1020227027772 A KR1020227027772 A KR 1020227027772A KR 20227027772 A KR20227027772 A KR 20227027772A KR 20220129026 A KR20220129026 A KR 20220129026A
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amyloid
amino acid
seq
ser
leu
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Korean (ko)
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조나단 에스. 월
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유니버시티 오브 테네시 리서치 파운데이션
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • A61K2239/11—Antigen recognition domain
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020227027772A 2020-01-17 2021-01-15 아밀로이드 제거를 위한 키메라 항원 수용체 Pending KR20220129026A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062962763P 2020-01-17 2020-01-17
US62/962,763 2020-01-17
PCT/US2021/013727 WO2021146620A2 (en) 2020-01-17 2021-01-15 Chimeric antigen receptors for removal of amyloid

Publications (1)

Publication Number Publication Date
KR20220129026A true KR20220129026A (ko) 2022-09-22

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KR1020227027772A Pending KR20220129026A (ko) 2020-01-17 2021-01-15 아밀로이드 제거를 위한 키메라 항원 수용체

Country Status (11)

Country Link
US (1) US20230068507A1 (https=)
EP (1) EP4090362A4 (https=)
JP (1) JP2023510603A (https=)
KR (1) KR20220129026A (https=)
CN (1) CN115175693A (https=)
AU (1) AU2021208630A1 (https=)
BR (1) BR112022013940A2 (https=)
CA (1) CA3164691A1 (https=)
IL (1) IL294740A (https=)
MX (1) MX2022008687A (https=)
WO (1) WO2021146620A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109553686A (zh) * 2017-09-26 2019-04-02 南京安吉生物科技有限公司 一种新型可调控的双嵌合抗原受体t细胞及其构建方法和应用
WO2022120378A1 (en) * 2020-12-04 2022-06-09 University Of Tennessee Research Foundation Method for diagnosing amyloid diseases
US20260070962A1 (en) * 2022-09-02 2026-03-12 University Of Tennessee Research Foundation Chimeric antigen receptors for removal of amyloid
SE548109C2 (en) * 2023-03-28 2026-03-30 Cerimmune Therapeutics Ab Microglial endocytic receptors for use in the treatment of neurodegenerative disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2173381T1 (sl) * 2007-05-14 2014-01-31 Novimmune Sa Fc receptor-vezavni polipeptidi z modificiranimi efektorskimi funkcijami
US10213506B2 (en) * 2014-08-26 2019-02-26 University Of Tennessee Research Foundation Targeting immunotherapy for amyloidosis
US20180186855A1 (en) * 2016-03-23 2018-07-05 Alector Llc Chimeric receptors and methods of use thereof
RU2746325C1 (ru) * 2017-06-29 2021-04-12 Зе Трастис Оф Коламбия Юниверсити Ин Зе Сити Оф Нью-Йорк Химерные антитела для лечения заболеваний, характеризующихся отложением амилоида
US11382974B2 (en) * 2017-08-01 2022-07-12 The Trustees Of Columbia University In The City Of New York Methods and compositions for treatment of amyloid deposition diseases
CN109837246A (zh) * 2017-11-25 2019-06-04 深圳宾德生物技术有限公司 一种敲除pd1的靶向ror1的嵌合抗原受体t细胞及其制备方法和应用
KR20200120917A (ko) * 2018-02-02 2020-10-22 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 키메라 항원 수용체를 발현하는 변형된 단핵구/대식세포/수지상 세포 및 단백질 응집체와 연관이 있는 질환 및 장애에서의 용도
US11246513B2 (en) * 2018-02-08 2022-02-15 Senseonics, Incorporated Data management system communications with a display device in an analyte monitoring system

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Publication number Publication date
EP4090362A2 (en) 2022-11-23
AU2021208630A1 (en) 2022-07-21
WO2021146620A2 (en) 2021-07-22
CA3164691A1 (en) 2021-07-22
WO2021146620A3 (en) 2021-09-23
MX2022008687A (es) 2022-10-27
JP2023510603A (ja) 2023-03-14
BR112022013940A2 (pt) 2022-09-20
EP4090362A4 (en) 2024-02-28
US20230068507A1 (en) 2023-03-02
CN115175693A (zh) 2022-10-11
IL294740A (en) 2022-09-01

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