CN115175693A - 用于去除淀粉样蛋白的嵌合抗原受体 - Google Patents
用于去除淀粉样蛋白的嵌合抗原受体 Download PDFInfo
- Publication number
- CN115175693A CN115175693A CN202180015824.4A CN202180015824A CN115175693A CN 115175693 A CN115175693 A CN 115175693A CN 202180015824 A CN202180015824 A CN 202180015824A CN 115175693 A CN115175693 A CN 115175693A
- Authority
- CN
- China
- Prior art keywords
- amyloid
- amino acid
- seq
- acid sequence
- chimeric receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/17—Monocytes; Macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
- A61K2239/11—Antigen recognition domain
- A61K2239/13—Antibody-based
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062962763P | 2020-01-17 | 2020-01-17 | |
| US62/962,763 | 2020-01-17 | ||
| PCT/US2021/013727 WO2021146620A2 (en) | 2020-01-17 | 2021-01-15 | Chimeric antigen receptors for removal of amyloid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115175693A true CN115175693A (zh) | 2022-10-11 |
Family
ID=76864318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180015824.4A Pending CN115175693A (zh) | 2020-01-17 | 2021-01-15 | 用于去除淀粉样蛋白的嵌合抗原受体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230068507A1 (https=) |
| EP (1) | EP4090362A4 (https=) |
| JP (1) | JP2023510603A (https=) |
| KR (1) | KR20220129026A (https=) |
| CN (1) | CN115175693A (https=) |
| AU (1) | AU2021208630A1 (https=) |
| BR (1) | BR112022013940A2 (https=) |
| CA (1) | CA3164691A1 (https=) |
| IL (1) | IL294740A (https=) |
| MX (1) | MX2022008687A (https=) |
| WO (1) | WO2021146620A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109553686A (zh) * | 2017-09-26 | 2019-04-02 | 南京安吉生物科技有限公司 | 一种新型可调控的双嵌合抗原受体t细胞及其构建方法和应用 |
| WO2022120378A1 (en) * | 2020-12-04 | 2022-06-09 | University Of Tennessee Research Foundation | Method for diagnosing amyloid diseases |
| US20260070962A1 (en) * | 2022-09-02 | 2026-03-12 | University Of Tennessee Research Foundation | Chimeric antigen receptors for removal of amyloid |
| SE548109C2 (en) * | 2023-03-28 | 2026-03-30 | Cerimmune Therapeutics Ab | Microglial endocytic receptors for use in the treatment of neurodegenerative disease |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2173381T1 (sl) * | 2007-05-14 | 2014-01-31 | Novimmune Sa | Fc receptor-vezavni polipeptidi z modificiranimi efektorskimi funkcijami |
| US10213506B2 (en) * | 2014-08-26 | 2019-02-26 | University Of Tennessee Research Foundation | Targeting immunotherapy for amyloidosis |
| US20180186855A1 (en) * | 2016-03-23 | 2018-07-05 | Alector Llc | Chimeric receptors and methods of use thereof |
| RU2746325C1 (ru) * | 2017-06-29 | 2021-04-12 | Зе Трастис Оф Коламбия Юниверсити Ин Зе Сити Оф Нью-Йорк | Химерные антитела для лечения заболеваний, характеризующихся отложением амилоида |
| US11382974B2 (en) * | 2017-08-01 | 2022-07-12 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for treatment of amyloid deposition diseases |
| CN109837246A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种敲除pd1的靶向ror1的嵌合抗原受体t细胞及其制备方法和应用 |
| KR20200120917A (ko) * | 2018-02-02 | 2020-10-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 키메라 항원 수용체를 발현하는 변형된 단핵구/대식세포/수지상 세포 및 단백질 응집체와 연관이 있는 질환 및 장애에서의 용도 |
| US11246513B2 (en) * | 2018-02-08 | 2022-02-15 | Senseonics, Incorporated | Data management system communications with a display device in an analyte monitoring system |
-
2021
- 2021-01-15 AU AU2021208630A patent/AU2021208630A1/en active Pending
- 2021-01-15 EP EP21741748.4A patent/EP4090362A4/en active Pending
- 2021-01-15 CN CN202180015824.4A patent/CN115175693A/zh active Pending
- 2021-01-15 KR KR1020227027772A patent/KR20220129026A/ko active Pending
- 2021-01-15 US US17/793,355 patent/US20230068507A1/en active Pending
- 2021-01-15 MX MX2022008687A patent/MX2022008687A/es unknown
- 2021-01-15 CA CA3164691A patent/CA3164691A1/en active Pending
- 2021-01-15 JP JP2022543410A patent/JP2023510603A/ja active Pending
- 2021-01-15 BR BR112022013940A patent/BR112022013940A2/pt unknown
- 2021-01-15 WO PCT/US2021/013727 patent/WO2021146620A2/en not_active Ceased
-
2022
- 2022-07-13 IL IL294740A patent/IL294740A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4090362A2 (en) | 2022-11-23 |
| AU2021208630A1 (en) | 2022-07-21 |
| WO2021146620A2 (en) | 2021-07-22 |
| CA3164691A1 (en) | 2021-07-22 |
| WO2021146620A3 (en) | 2021-09-23 |
| MX2022008687A (es) | 2022-10-27 |
| JP2023510603A (ja) | 2023-03-14 |
| BR112022013940A2 (pt) | 2022-09-20 |
| EP4090362A4 (en) | 2024-02-28 |
| KR20220129026A (ko) | 2022-09-22 |
| US20230068507A1 (en) | 2023-03-02 |
| IL294740A (en) | 2022-09-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20250215084A1 (en) | Antigen binding proteins specifically binding mage-a | |
| US9580493B2 (en) | Anti-α synuclein binding molecules | |
| CN115175693A (zh) | 用于去除淀粉样蛋白的嵌合抗原受体 | |
| JP2025011176A (ja) | 組換え免疫細胞、作製方法、および使用方法 | |
| KR20200083986A (ko) | Nyeso t 세포 수용체 | |
| JP6796123B2 (ja) | Xbp1ペプチド、cd138ペプチドおよびcs1ペプチド | |
| CA3115139A1 (en) | Compositions and methods regarding engineered and non-engineered .gamma..delta.-t cells for treatment of hematological tumors | |
| JP2020511950A (ja) | 抗lilrb3抗体およびその使用の方法 | |
| KR20220057575A (ko) | 항-steap1 항체 및 이의 용도 | |
| CA3141334A1 (en) | Anti-psgl-1 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof | |
| KR20240058050A (ko) | 아밀로이드 장애 치료를 위한 항체-펩티드 융합 단백질 | |
| EP4551610A1 (en) | Cnx antigen-binding molecules | |
| KR20220002891A (ko) | 자가항체-매개 자가면역 질병의 치료를 위한 항-cd38 항체 및 이의 약제학적 조성물 | |
| JP2022527813A (ja) | Magea1特異的t細胞受容体およびその使用 | |
| US20200255507A1 (en) | Nano-theranostics for parkinson's disease | |
| US20190359677A1 (en) | Novel t cell receptors and immune therapy using the same for the treatment of cancer and infectious diseases | |
| US20260070962A1 (en) | Chimeric antigen receptors for removal of amyloid | |
| US12209137B2 (en) | Antigen binding proteins specifically binding CT45 | |
| US20240122980A1 (en) | Use of tim-3 cytoplasmic tail in chimeric antigen receptors | |
| EP4323389A1 (en) | T-cell receptors specific for both rac1- and rac2-derived mutated epitopes | |
| WO2026055521A1 (en) | Antibody-peptide fusion proteins for treating amyloid disorders | |
| CN117769565A (zh) | 融合蛋白及其在治疗膜性肾病中的用途 | |
| HK40015176A (zh) | 抗lilrb3抗体及其使用方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |