KR20220104270A - 젬시타빈-전구 약물 함유 제제 - Google Patents
젬시타빈-전구 약물 함유 제제 Download PDFInfo
- Publication number
- KR20220104270A KR20220104270A KR1020227023672A KR20227023672A KR20220104270A KR 20220104270 A KR20220104270 A KR 20220104270A KR 1020227023672 A KR1020227023672 A KR 1020227023672A KR 20227023672 A KR20227023672 A KR 20227023672A KR 20220104270 A KR20220104270 A KR 20220104270A
- Authority
- KR
- South Korea
- Prior art keywords
- formulation
- dma
- gemcitabine
- phosphate
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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| ES2569185T3 (es) | 2011-03-01 | 2016-05-09 | Nucana Biomed Limited | Derivados de fosforamidato de 5-fluoro-2'-desoxiuridina para uso en el tratamiento del cáncer |
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| RS56752B1 (sr) * | 2014-06-25 | 2018-04-30 | NuCana plc | Formulacija koja sadrži gemcitabin-prolek |
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| PL3224268T3 (pl) | 2014-11-28 | 2019-11-29 | NuCana plc | Nowe pochodne 3'-deoksyadenozyny amidofosforanów estrów aminokwasów 2' i/lub 5' jako związki przeciwnowotworowe |
| CN106543252A (zh) * | 2015-09-16 | 2017-03-29 | 博瑞生物医药（苏州）股份有限公司 | 核苷氨基磷酸酯类前药的制备方法及其中间体 |
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| CN106539810B (zh) | 2015-09-16 | 2021-03-09 | 济南高合医疗科技有限公司 | 一种富集了nuc-1031单一异构体的组合物及其制备方法和用途 |
| CN108135920A (zh) | 2015-10-05 | 2018-06-08 | 努卡那有限公司 | 组合疗法 |
| HRP20211812T1 (hr) | 2015-12-11 | 2022-03-04 | NuCana plc | Dijastereoselektivna sinteza derivata fosfata i prolijeka gemcitabina nuc-1031 |
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| KR102657458B1 (ko) | 2016-11-02 | 2024-04-12 | 센트렉시온 테라퓨틱스 코포레이션 | 안정한 수성의 캡사이신 주사 가능한 제형 및 이의 의학적 용도 |
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| IL272036B2 (en) | 2017-07-20 | 2025-01-01 | Centrexion Therapeutics Corp | Methods and compositions for treating pain using capsaicin |
| GB201715011D0 (en) | 2017-09-18 | 2017-11-01 | Nucana Biomed Ltd | Floxuridine synthesis |
| CN109956986B (zh) | 2017-12-22 | 2021-04-27 | 浙江柏拉阿图医药科技有限公司 | 肝递送吉西他滨前体药物核苷环磷酸酯化合物及应用 |
| WO2023076878A1 (en) * | 2021-10-26 | 2023-05-04 | Emphascience Inc. | Ready-to-dilute formulation |
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| ATE212661T1 (de) | 1998-01-23 | 2002-02-15 | Newbiotics Inc | Durch enzymkatalyse erhaltene therapeutische substanzen. |
| US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| ATE429438T1 (de) | 1999-07-22 | 2009-05-15 | Celmed Oncology Usa Inc | Enzym katalisierte therapeutische aktivierung |
| CN1181829C (zh) * | 2000-11-03 | 2004-12-29 | 中国人民解放军军事医学科学院附属医院 | 吉西他滨溶液制剂 |
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| JP5528708B2 (ja) * | 2006-02-09 | 2014-06-25 | 参天製薬株式会社 | 安定な製剤ならびにそれらを調製および使用する方法 |
| EP1913962A1 (en) * | 2006-10-22 | 2008-04-23 | Ophir Perelson | Expandable medical device for the treatment and prevention of cardiovascular diseases |
| WO2011008985A2 (en) * | 2009-07-15 | 2011-01-20 | Georgia Tech Research Corporation | Methods and compositions for improved delivery of therapeutic and diagnostic agents |
| KR20120086729A (ko) * | 2009-11-20 | 2012-08-03 | 클라비스 파마 에이에스에이 | 젬시타빈 유도체의 비경구적 제제 |
| CN101926757B (zh) * | 2010-09-01 | 2013-01-02 | 北京大学 | 一种难溶性药物的液体组合物及其制备方法 |
| KR101231925B1 (ko) * | 2010-10-27 | 2013-02-08 | 씨제이제일제당 (주) | 젬시타빈의 전구약물 및 이의 제조방법 |
| ES2575676T3 (es) * | 2012-01-20 | 2016-06-30 | Aratana Therapeutics Nv | Composición de colirio |
| CN104955458A (zh) * | 2012-11-07 | 2015-09-30 | Z·索 | 取代的吉西他滨芳基酰胺类似物和使用所述类似物的治疗方法 |
| HUE033335T2 (en) | 2012-11-16 | 2017-11-28 | Univ College Cardiff Consultants Ltd | Mixture of rp/sp gemcitabine-[phenyl-(benzyloxy-l-alaninyl)]-phosphate |
| CA2931458A1 (en) | 2013-11-27 | 2015-06-04 | Idenix Pharmaceuticals Llc | Nucleotides for the treatment of liver cancer |
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| RS56752B1 (sr) | 2014-06-25 | 2018-04-30 | NuCana plc | Formulacija koja sadrži gemcitabin-prolek |
| ES2830784T3 (es) | 2014-07-22 | 2021-06-04 | NuCana plc | Proceso para la preparación de gemcitabina-[fenil(benzoxi-L-alanil)]fosfato |
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| CN108135920A (zh) | 2015-10-05 | 2018-06-08 | 努卡那有限公司 | 组合疗法 |
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| Title |
|---|
| Slusarczyk et all; J. Med. Chem.; 2014, 57, 1531-1542 |
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