KR20220004969A - 용해 가능한 중합체 눈 삽입물 및 이를 이용하는 방법 - Google Patents

용해 가능한 중합체 눈 삽입물 및 이를 이용하는 방법 Download PDF

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Publication number
KR20220004969A
KR20220004969A KR1020217033138A KR20217033138A KR20220004969A KR 20220004969 A KR20220004969 A KR 20220004969A KR 1020217033138 A KR1020217033138 A KR 1020217033138A KR 20217033138 A KR20217033138 A KR 20217033138A KR 20220004969 A KR20220004969 A KR 20220004969A
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KR
South Korea
Prior art keywords
polymeric
eye
insert
ocular
guar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020217033138A
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English (en)
Korean (ko)
Inventor
호워드 알렌 케텔슨
레카 랑가라잔
월터 알 라레도
스티븐 존 콜린스
Original Assignee
알콘 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 알콘 인코포레이티드 filed Critical 알콘 인코포레이티드
Publication of KR20220004969A publication Critical patent/KR20220004969A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020217033138A 2019-05-02 2020-05-01 용해 가능한 중합체 눈 삽입물 및 이를 이용하는 방법 Ceased KR20220004969A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962841901P 2019-05-02 2019-05-02
US62/841,901 2019-05-02
US201962927885P 2019-10-30 2019-10-30
US62/927,885 2019-10-30
PCT/IB2020/054148 WO2020222195A1 (en) 2019-05-02 2020-05-01 Dissolvable polymeric eye inserts and method of using same

Publications (1)

Publication Number Publication Date
KR20220004969A true KR20220004969A (ko) 2022-01-12

Family

ID=70554143

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217033138A Ceased KR20220004969A (ko) 2019-05-02 2020-05-01 용해 가능한 중합체 눈 삽입물 및 이를 이용하는 방법

Country Status (12)

Country Link
US (1) US12102559B2 (https=)
EP (1) EP3962450A1 (https=)
JP (1) JP7350885B2 (https=)
KR (1) KR20220004969A (https=)
CN (1) CN113795242A (https=)
AU (1) AU2020266339B2 (https=)
BR (1) BR112021019774A2 (https=)
CA (1) CA3137417C (https=)
MX (1) MX2021013428A (https=)
SG (1) SG11202110514RA (https=)
TW (1) TWI826685B (https=)
WO (1) WO2020222195A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
EP3969070B1 (en) 2019-05-13 2026-03-11 University of Pittsburgh - of the Commonwealth System of Higher Education Polymer-based implant for retinal therapy and methods of making and using the same
CA3166738A1 (en) 2020-02-06 2021-08-12 Charles D. Blizzard Travoprost compositions and methods for treating ocular diseases
WO2021222117A1 (en) 2020-04-27 2021-11-04 Ocular Therapeutix, Inc. Methods of treating allergic conjunctivitis
EP4432990A4 (en) * 2021-11-16 2025-07-30 Univ Pittsburgh Commonwealth Sys Higher Education POLYMER-BASED GEL IMPLANT FOR RETINAL THERAPY AND METHODS OF MAKING AND USING THE SAME
WO2023119228A1 (en) * 2021-12-23 2023-06-29 Alcon Inc. Dissolvable medical device for drugs delivery
TW202341919A (zh) * 2021-12-23 2023-11-01 瑞士商愛爾康公司 用於角膜表面保護之可溶解醫療裝置及套件
TW202339704A (zh) * 2021-12-23 2023-10-16 瑞士商愛爾康公司 用於促進傷口癒合的可溶解醫療裝置
WO2023214027A1 (en) * 2022-05-06 2023-11-09 Eyed Pharma Insert for the treatment of dry eyes
US20240207174A1 (en) * 2022-12-23 2024-06-27 Alcon Inc. Dissolvable polymeric eye inserts
WO2024180472A1 (en) * 2023-02-28 2024-09-06 Alcon Inc. Ocular inserts
WO2024180453A1 (en) * 2023-02-28 2024-09-06 Alcon Inc. Dissolvable polymeric eye inserts with a non-ionic cellulose derivative

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT75625B (en) 1981-10-08 1985-12-09 Merck & Co Inc Process for preparing biosoluble ocular insert
US4730013A (en) * 1981-10-08 1988-03-08 Merck & Co., Inc. Biosoluble ocular insert
DE69628293D1 (de) 1995-06-07 2003-06-26 Keravision Inc Radiales intrastromales hornhautimplantat
KR20070121754A (ko) 2005-03-21 2007-12-27 마커사이트, 인코포레이티드 질환 또는 상태의 치료를 위한 약물 송달 시스템
AU2006330915B2 (en) 2005-12-23 2011-02-03 Intercontinental Great Brands Llc Compositions providing a sensation substantially similar to that provided by menthol
KR101555291B1 (ko) 2007-02-09 2015-09-30 알콘, 인코퍼레이티드 세가지 폴리머의 상승성 배합물을 함유하는 안과 조성물
US20130244978A1 (en) * 2007-09-14 2013-09-19 Rohto Pharmaceutical Co., Ltd. Ophthalmic composition
US20130172357A1 (en) 2011-02-03 2013-07-04 Eye Therapies Llc Compositions and Methods for Treatment of Glaucoma
US20120215184A1 (en) 2011-02-18 2012-08-23 Valeant International (Barbados) Srl Cylindrical ocular inserts
US20140107025A1 (en) 2012-04-16 2014-04-17 Jade Therapeutics, Llc Ocular drug delivery system
UA113434C2 (uk) 2012-05-04 2017-01-25 Алкон Рісерч, Лтд. Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням
RU2683651C2 (ru) 2013-06-18 2019-04-01 Иван Дмитриевич Захаров Лекарственное средство для лечения кератоконуса и других дегенеративных заболеваний роговицы и фармацевтические препараты на его основе
US9782345B2 (en) 2013-10-17 2017-10-10 Jade Therapeutics, Inc. Ocular composition and method
CA2947274C (en) * 2014-04-28 2019-03-19 Hampton Technologies Ophthalmic compositions and methods for treating eyes
US9789058B2 (en) 2014-06-20 2017-10-17 Coopervision International Holding Company, Lp Ophthalmic composition for the treatment of ocular infection
CN109481447A (zh) 2014-09-06 2019-03-19 整体生物系统有限责任公司 用于在眼中实现持续药物释放的方法和生物相容性组合物

Also Published As

Publication number Publication date
CA3137417A1 (en) 2020-11-05
AU2020266339A1 (en) 2021-12-23
CN113795242A (zh) 2021-12-14
JP2022530758A (ja) 2022-07-01
EP3962450A1 (en) 2022-03-09
US12102559B2 (en) 2024-10-01
SG11202110514RA (en) 2021-11-29
TW202106286A (zh) 2021-02-16
WO2020222195A1 (en) 2020-11-05
AU2020266339B2 (en) 2023-12-07
MX2021013428A (es) 2021-12-10
BR112021019774A2 (pt) 2021-12-07
CA3137417C (en) 2024-01-09
TWI826685B (zh) 2023-12-21
JP7350885B2 (ja) 2023-09-26
US20200345544A1 (en) 2020-11-05

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Patent event date: 20211014

Patent event code: PA01051R01D

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PA0201 Request for examination

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Patent event date: 20211207

Comment text: Request for Examination of Application

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Patent event date: 20240628

Patent event code: PE09021S01D

E601 Decision to refuse application
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Patent event date: 20250320

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Patent event code: PE06012S01D