JP7350885B2 - 溶解性ポリマー製眼用インサート及びその使用方法 - Google Patents

溶解性ポリマー製眼用インサート及びその使用方法 Download PDF

Info

Publication number
JP7350885B2
JP7350885B2 JP2021561006A JP2021561006A JP7350885B2 JP 7350885 B2 JP7350885 B2 JP 7350885B2 JP 2021561006 A JP2021561006 A JP 2021561006A JP 2021561006 A JP2021561006 A JP 2021561006A JP 7350885 B2 JP7350885 B2 JP 7350885B2
Authority
JP
Japan
Prior art keywords
insert
polymeric ophthalmic
ophthalmic insert
eye
polymeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021561006A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022530758A5 (https=
JPWO2020222195A5 (https=
JP2022530758A (ja
Inventor
ケテルソン，ハワード・アレン
ランガージャン，レカー
ラレド，ウォルター・アール
コリンズ，ステファン・ジョン
Original Assignee
アルコン インク．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アルコン インク． filed Critical アルコン インク．
Publication of JP2022530758A publication Critical patent/JP2022530758A/ja
Publication of JP2022530758A5 publication Critical patent/JP2022530758A5/ja
Publication of JPWO2020222195A5 publication Critical patent/JPWO2020222195A5/ja
Application granted granted Critical
Publication of JP7350885B2 publication Critical patent/JP7350885B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021561006A 2019-05-02 2020-05-01 溶解性ポリマー製眼用インサート及びその使用方法 Active JP7350885B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962841901P 2019-05-02 2019-05-02
US62/841,901 2019-05-02
US201962927885P 2019-10-30 2019-10-30
US62/927,885 2019-10-30
PCT/IB2020/054148 WO2020222195A1 (en) 2019-05-02 2020-05-01 Dissolvable polymeric eye inserts and method of using same

Publications (4)

Publication Number Publication Date
JP2022530758A JP2022530758A (ja) 2022-07-01
JP2022530758A5 JP2022530758A5 (https=) 2023-06-07
JPWO2020222195A5 JPWO2020222195A5 (https=) 2023-06-07
JP7350885B2 true JP7350885B2 (ja) 2023-09-26

Family

ID=70554143

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021561006A Active JP7350885B2 (ja) 2019-05-02 2020-05-01 溶解性ポリマー製眼用インサート及びその使用方法

Country Status (12)

Country Link
US (1) US12102559B2 (https=)
EP (1) EP3962450A1 (https=)
JP (1) JP7350885B2 (https=)
KR (1) KR20220004969A (https=)
CN (1) CN113795242A (https=)
AU (1) AU2020266339B2 (https=)
BR (1) BR112021019774A2 (https=)
CA (1) CA3137417C (https=)
MX (1) MX2021013428A (https=)
SG (1) SG11202110514RA (https=)
TW (1) TWI826685B (https=)
WO (1) WO2020222195A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
EP3969070B1 (en) 2019-05-13 2026-03-11 University of Pittsburgh - of the Commonwealth System of Higher Education Polymer-based implant for retinal therapy and methods of making and using the same
CA3166738A1 (en) 2020-02-06 2021-08-12 Charles D. Blizzard Travoprost compositions and methods for treating ocular diseases
WO2021222117A1 (en) 2020-04-27 2021-11-04 Ocular Therapeutix, Inc. Methods of treating allergic conjunctivitis
EP4432990A4 (en) * 2021-11-16 2025-07-30 Univ Pittsburgh Commonwealth Sys Higher Education POLYMER-BASED GEL IMPLANT FOR RETINAL THERAPY AND METHODS OF MAKING AND USING THE SAME
WO2023119228A1 (en) * 2021-12-23 2023-06-29 Alcon Inc. Dissolvable medical device for drugs delivery
TW202341919A (zh) * 2021-12-23 2023-11-01 瑞士商愛爾康公司 用於角膜表面保護之可溶解醫療裝置及套件
TW202339704A (zh) * 2021-12-23 2023-10-16 瑞士商愛爾康公司 用於促進傷口癒合的可溶解醫療裝置
WO2023214027A1 (en) * 2022-05-06 2023-11-09 Eyed Pharma Insert for the treatment of dry eyes
US20240207174A1 (en) * 2022-12-23 2024-06-27 Alcon Inc. Dissolvable polymeric eye inserts
WO2024180472A1 (en) * 2023-02-28 2024-09-06 Alcon Inc. Ocular inserts
WO2024180453A1 (en) * 2023-02-28 2024-09-06 Alcon Inc. Dissolvable polymeric eye inserts with a non-ionic cellulose derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010518116A (ja) 2007-02-09 2010-05-27 アルコン，インコーポレイテッド ３種のポリマーの相乗的組み合わせを含む眼科用組成物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT75625B (en) 1981-10-08 1985-12-09 Merck & Co Inc Process for preparing biosoluble ocular insert
US4730013A (en) * 1981-10-08 1988-03-08 Merck & Co., Inc. Biosoluble ocular insert
DE69628293D1 (de) 1995-06-07 2003-06-26 Keravision Inc Radiales intrastromales hornhautimplantat
KR20070121754A (ko) 2005-03-21 2007-12-27 마커사이트, 인코포레이티드 질환 또는 상태의 치료를 위한 약물 송달 시스템
AU2006330915B2 (en) 2005-12-23 2011-02-03 Intercontinental Great Brands Llc Compositions providing a sensation substantially similar to that provided by menthol
US20130244978A1 (en) * 2007-09-14 2013-09-19 Rohto Pharmaceutical Co., Ltd. Ophthalmic composition
US20130172357A1 (en) 2011-02-03 2013-07-04 Eye Therapies Llc Compositions and Methods for Treatment of Glaucoma
US20120215184A1 (en) 2011-02-18 2012-08-23 Valeant International (Barbados) Srl Cylindrical ocular inserts
US20140107025A1 (en) 2012-04-16 2014-04-17 Jade Therapeutics, Llc Ocular drug delivery system
UA113434C2 (uk) 2012-05-04 2017-01-25 Алкон Рісерч, Лтд. Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням
RU2683651C2 (ru) 2013-06-18 2019-04-01 Иван Дмитриевич Захаров Лекарственное средство для лечения кератоконуса и других дегенеративных заболеваний роговицы и фармацевтические препараты на его основе
US9782345B2 (en) 2013-10-17 2017-10-10 Jade Therapeutics, Inc. Ocular composition and method
CA2947274C (en) * 2014-04-28 2019-03-19 Hampton Technologies Ophthalmic compositions and methods for treating eyes
US9789058B2 (en) 2014-06-20 2017-10-17 Coopervision International Holding Company, Lp Ophthalmic composition for the treatment of ocular infection
CN109481447A (zh) 2014-09-06 2019-03-19 整体生物系统有限责任公司 用于在眼中实现持续药物释放的方法和生物相容性组合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010518116A (ja) 2007-02-09 2010-05-27 アルコン，インコーポレイテッド ３種のポリマーの相乗的組み合わせを含む眼科用組成物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Graefes Arch Clin Exp Ophthalmol，2011年，Vol. 249, No. 10，pp. 1503-1510，DOI:10.1007/s00417-011-1703-z
Indonesian Journal of Clinical Pharmacy，2015年，Vol. 4, No. 4，pp. 281-288，DOI:10.15416/ijcp.2015.4.4.281
International Journal of Pharmaceutics，1989年，Vol. 51, No. 3，pp. 203-212，DOI:10.1016/0378-5173(89)90193-2

Also Published As

Publication number Publication date
CA3137417A1 (en) 2020-11-05
AU2020266339A1 (en) 2021-12-23
CN113795242A (zh) 2021-12-14
JP2022530758A (ja) 2022-07-01
EP3962450A1 (en) 2022-03-09
US12102559B2 (en) 2024-10-01
SG11202110514RA (en) 2021-11-29
KR20220004969A (ko) 2022-01-12
TW202106286A (zh) 2021-02-16
WO2020222195A1 (en) 2020-11-05
AU2020266339B2 (en) 2023-12-07
MX2021013428A (es) 2021-12-10
BR112021019774A2 (pt) 2021-12-07
CA3137417C (en) 2024-01-09
TWI826685B (zh) 2023-12-21
US20200345544A1 (en) 2020-11-05

Similar Documents

Publication Publication Date Title
JP7350885B2 (ja) 溶解性ポリマー製眼用インサート及びその使用方法
JP7406634B2 (ja) 生分解性ポリマーを有する溶解性ポリマー眼科用インサート
JP6888754B2 (ja) インサイチュでゲルを形成する医薬製剤
JP2018531292A6 (ja) インサイチュでゲルを形成する医薬製剤
US20230372236A1 (en) Drug containing dissolvable ocular inserts and method of using same
RU2791026C1 (ru) Растворимые полимерные глазные вставки и способ их применения
JP7358526B2 (ja) 向上した眼の快適性を提供する組成物
US12527688B2 (en) Dissolvable medical device for drugs delivery
US20250195416A1 (en) Dissolvable polymeric ocular insert for drugs delivery
WO2024180453A1 (en) Dissolvable polymeric eye inserts with a non-ionic cellulose derivative
RU2802441C1 (ru) Растворимые полимерные офтальмологические вкладки с биоразлагаемым полимером
WO2024180472A1 (en) Ocular inserts
Mundada Update on Polymers for Ocular Drug Delivery
WO2024134361A1 (en) Salt activatable dissolvable polymeric eye inserts and kit of the same

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20211203

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20221227

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230327

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230529

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20230529

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230829

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230913

R150 Certificate of patent or registration of utility model

Ref document number: 7350885

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150