KR20210119403A - 통증, 염증 및/또는 자가 면역의 치료 또는 예방용 화합물 - Google Patents

통증, 염증 및/또는 자가 면역의 치료 또는 예방용 화합물 Download PDF

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Publication number
KR20210119403A
KR20210119403A KR1020217023524A KR20217023524A KR20210119403A KR 20210119403 A KR20210119403 A KR 20210119403A KR 1020217023524 A KR1020217023524 A KR 1020217023524A KR 20217023524 A KR20217023524 A KR 20217023524A KR 20210119403 A KR20210119403 A KR 20210119403A
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South Korea
Prior art keywords
polymorph
pain
treatment
inflammation
autoimmunity
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Ceased
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KR1020217023524A
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English (en)
Korean (ko)
Inventor
엘리 카플란
로버트 헷
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노바레메드 리미티드
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Publication of KR20210119403A publication Critical patent/KR20210119403A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020217023524A 2019-01-23 2020-01-22 통증, 염증 및/또는 자가 면역의 치료 또는 예방용 화합물 Ceased KR20210119403A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19153315 2019-01-23
EP19153315.7 2019-01-23
PCT/EP2020/051528 WO2020152226A1 (en) 2019-01-23 2020-01-22 Compounds for use in the treatment or prophylaxis of pain, inflammation and/or autoimmunity

Publications (1)

Publication Number Publication Date
KR20210119403A true KR20210119403A (ko) 2021-10-05

Family

ID=65228356

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217023524A Ceased KR20210119403A (ko) 2019-01-23 2020-01-22 통증, 염증 및/또는 자가 면역의 치료 또는 예방용 화합물

Country Status (17)

Country Link
US (1) US11891350B2 (https=)
EP (1) EP3860582B1 (https=)
JP (2) JP7611148B2 (https=)
KR (1) KR20210119403A (https=)
CN (1) CN113329746B (https=)
AU (1) AU2020210831B2 (https=)
BR (1) BR112021019476A2 (https=)
CA (1) CA3118996A1 (https=)
DK (1) DK3860582T3 (https=)
ES (1) ES2913977T3 (https=)
IL (1) IL282718B2 (https=)
PL (1) PL3860582T3 (https=)
PT (1) PT3860582T (https=)
RS (1) RS63270B1 (https=)
SG (1) SG11202111773QA (https=)
WO (1) WO2020152226A1 (https=)
ZA (1) ZA202107346B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3939578A1 (en) * 2020-07-13 2022-01-19 Novaremed Ltd. Compounds for treatment or prevention of an infection resulting from a coronavirus and/or a coronavirus-induced disease
WO2026037478A1 (en) 2023-08-11 2026-02-19 Novaremed AG (s,s)-(3-o-(propan-2-ol)-2-amino-prop-1-yl-4-hydroxybenzene and its analogues for the treatment of chronic pain

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7642290B2 (en) 2002-10-03 2010-01-05 Novaremed Limited Compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection
JP4939396B2 (ja) * 2004-03-26 2012-05-23 ノヴァレメッド リミテッド Ａｉｄｓ及び他のウイルス性疾患及びｈｉｖ関連感染症の改善又はその治療用化合物及びそのような化合物を含む組成物、そのような疾患及び感染症の治療方法及びそのような化合物及び組成物の製造方法
GB0804213D0 (en) 2008-03-06 2008-04-16 New Era Biotech Ltd A method of printing or preventing pain
CN102821761B (zh) * 2009-09-09 2015-06-10 诺瓦麦有限公司 用于治疗疼痛和炎症的n-取代的苯丙酰胺或苯丙烯酰胺
US8802734B2 (en) 2009-09-09 2014-08-12 Novaremed Limited Method of treating or preventing pain
GB0916073D0 (en) 2009-09-14 2009-10-28 Cintec Int Ltd Improvements in and relating to building anchor systems
AU2012348529B2 (en) 2011-12-08 2017-03-30 Novaremed Ltd. Isolated stereoisomeric forms of (S) 2-N (3-O-(propan 2-ol) -1-propyl-4-hydroxybenzene) -3-phenylpropylamide

Also Published As

Publication number Publication date
AU2020210831B2 (en) 2025-02-13
ZA202107346B (en) 2023-10-25
JP7611148B2 (ja) 2025-01-09
PL3860582T3 (pl) 2022-08-01
ES2913977T3 (es) 2022-06-07
DK3860582T3 (da) 2022-05-23
IL282718B1 (en) 2024-04-01
EP3860582A1 (en) 2021-08-11
US11891350B2 (en) 2024-02-06
IL282718B2 (en) 2024-08-01
CA3118996A1 (en) 2020-07-30
SG11202111773QA (en) 2021-11-29
AU2020210831A1 (en) 2021-05-20
JP2025036479A (ja) 2025-03-14
CN113329746A (zh) 2021-08-31
RS63270B1 (sr) 2022-06-30
JP2022518288A (ja) 2022-03-14
IL282718A (en) 2021-06-30
WO2020152226A1 (en) 2020-07-30
PT3860582T (pt) 2022-07-08
CN113329746B (zh) 2025-05-02
BR112021019476A2 (pt) 2021-11-30
EP3860582B1 (en) 2022-05-04
US20220002228A1 (en) 2022-01-06

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