JP7611148B2 - 疼痛、炎症および／または自己免疫の処置または予防における使用のための化合物 - Google Patents

疼痛、炎症および／または自己免疫の処置または予防における使用のための化合物 Download PDF

Info

Publication number
JP7611148B2
JP7611148B2 JP2021543276A JP2021543276A JP7611148B2 JP 7611148 B2 JP7611148 B2 JP 7611148B2 JP 2021543276 A JP2021543276 A JP 2021543276A JP 2021543276 A JP2021543276 A JP 2021543276A JP 7611148 B2 JP7611148 B2 JP 7611148B2
Authority
JP
Japan
Prior art keywords
polymorph
pain
composition
treatment
inflammation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021543276A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022518288A5 (https=
JP2022518288A (ja
Inventor
エリ カプラン，
ロベルト ヘット，
Original Assignee
ノヴァレメド リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノヴァレメド リミテッド filed Critical ノヴァレメド リミテッド
Publication of JP2022518288A publication Critical patent/JP2022518288A/ja
Publication of JP2022518288A5 publication Critical patent/JP2022518288A5/ja
Priority to JP2024226332A priority Critical patent/JP2025036479A/ja
Application granted granted Critical
Publication of JP7611148B2 publication Critical patent/JP7611148B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2021543276A 2019-01-23 2020-01-22 疼痛、炎症および／または自己免疫の処置または予防における使用のための化合物 Active JP7611148B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024226332A JP2025036479A (ja) 2019-01-23 2024-12-23 疼痛、炎症および／または自己免疫の処置または予防における使用のための化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19153315 2019-01-23
EP19153315.7 2019-01-23
PCT/EP2020/051528 WO2020152226A1 (en) 2019-01-23 2020-01-22 Compounds for use in the treatment or prophylaxis of pain, inflammation and/or autoimmunity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024226332A Division JP2025036479A (ja) 2019-01-23 2024-12-23 疼痛、炎症および／または自己免疫の処置または予防における使用のための化合物

Publications (3)

Publication Number Publication Date
JP2022518288A JP2022518288A (ja) 2022-03-14
JP2022518288A5 JP2022518288A5 (https=) 2023-01-20
JP7611148B2 true JP7611148B2 (ja) 2025-01-09

Family

ID=65228356

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021543276A Active JP7611148B2 (ja) 2019-01-23 2020-01-22 疼痛、炎症および／または自己免疫の処置または予防における使用のための化合物
JP2024226332A Pending JP2025036479A (ja) 2019-01-23 2024-12-23 疼痛、炎症および／または自己免疫の処置または予防における使用のための化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024226332A Pending JP2025036479A (ja) 2019-01-23 2024-12-23 疼痛、炎症および／または自己免疫の処置または予防における使用のための化合物

Country Status (17)

Country Link
US (1) US11891350B2 (https=)
EP (1) EP3860582B1 (https=)
JP (2) JP7611148B2 (https=)
KR (1) KR20210119403A (https=)
CN (1) CN113329746B (https=)
AU (1) AU2020210831B2 (https=)
BR (1) BR112021019476A2 (https=)
CA (1) CA3118996A1 (https=)
DK (1) DK3860582T3 (https=)
ES (1) ES2913977T3 (https=)
IL (1) IL282718B2 (https=)
PL (1) PL3860582T3 (https=)
PT (1) PT3860582T (https=)
RS (1) RS63270B1 (https=)
SG (1) SG11202111773QA (https=)
WO (1) WO2020152226A1 (https=)
ZA (1) ZA202107346B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3939578A1 (en) * 2020-07-13 2022-01-19 Novaremed Ltd. Compounds for treatment or prevention of an infection resulting from a coronavirus and/or a coronavirus-induced disease
WO2026037478A1 (en) 2023-08-11 2026-02-19 Novaremed AG (s,s)-(3-o-(propan-2-ol)-2-amino-prop-1-yl-4-hydroxybenzene and its analogues for the treatment of chronic pain

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007531717A (ja) 2004-03-26 2007-11-08 ニュー エラ バイオテック リミテッド Ａｉｄｓ及び他のウイルス性疾患及びｈｉｖ関連感染症の改善又はその治療用化合物及びそのような化合物を含む組成物、そのような疾患及び感染症の治療方法及びそのような化合物及び組成物の製造方法
US20110086910A1 (en) 2009-09-09 2011-04-14 Novaremed Limited Method of treating or preventing pain
JP2015500831A (ja) 2011-12-08 2015-01-08 ノヴァレメド リミテッド （ｓ）２−ｎ（３−ｏ−（プロパン２−オール）−１−プロピル−４−ヒドロキシベンゼン）−３−フェニルプロピルアミドの単離された立体異性体型

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7642290B2 (en) 2002-10-03 2010-01-05 Novaremed Limited Compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection
GB0804213D0 (en) 2008-03-06 2008-04-16 New Era Biotech Ltd A method of printing or preventing pain
CN102821761B (zh) * 2009-09-09 2015-06-10 诺瓦麦有限公司 用于治疗疼痛和炎症的n-取代的苯丙酰胺或苯丙烯酰胺
GB0916073D0 (en) 2009-09-14 2009-10-28 Cintec Int Ltd Improvements in and relating to building anchor systems

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007531717A (ja) 2004-03-26 2007-11-08 ニュー エラ バイオテック リミテッド Ａｉｄｓ及び他のウイルス性疾患及びｈｉｖ関連感染症の改善又はその治療用化合物及びそのような化合物を含む組成物、そのような疾患及び感染症の治療方法及びそのような化合物及び組成物の製造方法
US20110086910A1 (en) 2009-09-09 2011-04-14 Novaremed Limited Method of treating or preventing pain
JP2015500831A (ja) 2011-12-08 2015-01-08 ノヴァレメド リミテッド （ｓ）２−ｎ（３−ｏ−（プロパン２−オール）−１−プロピル−４−ヒドロキシベンゼン）−３−フェニルプロピルアミドの単離された立体異性体型

Also Published As

Publication number Publication date
AU2020210831B2 (en) 2025-02-13
ZA202107346B (en) 2023-10-25
PL3860582T3 (pl) 2022-08-01
ES2913977T3 (es) 2022-06-07
DK3860582T3 (da) 2022-05-23
IL282718B1 (en) 2024-04-01
KR20210119403A (ko) 2021-10-05
EP3860582A1 (en) 2021-08-11
US11891350B2 (en) 2024-02-06
IL282718B2 (en) 2024-08-01
CA3118996A1 (en) 2020-07-30
SG11202111773QA (en) 2021-11-29
AU2020210831A1 (en) 2021-05-20
JP2025036479A (ja) 2025-03-14
CN113329746A (zh) 2021-08-31
RS63270B1 (sr) 2022-06-30
JP2022518288A (ja) 2022-03-14
IL282718A (en) 2021-06-30
WO2020152226A1 (en) 2020-07-30
PT3860582T (pt) 2022-07-08
CN113329746B (zh) 2025-05-02
BR112021019476A2 (pt) 2021-11-30
EP3860582B1 (en) 2022-05-04
US20220002228A1 (en) 2022-01-06

Similar Documents

Publication Publication Date Title
JP5371790B2 (ja) 睡眠および認知に関するうつ病における残存症状の治療のための組み合わされたセロトニン再取り込み、５−ｈｔ３および５−ｈｔ１ａ活性を有する化合物としての１−［２−（２，４−ジメチルフェニルスルファニル）フェニル］ピペラジン
US20240082239A1 (en) Therapeutic Uses of Compounds Having Combined Sert, 5-HT3 and 5-HT1a Activity
JP2025036479A (ja) 疼痛、炎症および／または自己免疫の処置または予防における使用のための化合物
TWI441630B (zh) 曲馬朵（Ｔｒａｍａｄｏｌ）和可舒葆（Ｃｏｘｉｂ）之共結晶物
EP2475361B1 (en) N-substituted benzenepropanamides for use in the treatment of pain and inflammation
HK40061961B (en) Compounds for use in the treatment or prophylaxis of pain, inflammation and/or autoimmunity
HK40061961A (en) Compounds for use in the treatment or prophylaxis of pain, inflammation and/or autoimmunity
WO2026037478A1 (en) (s,s)-(3-o-(propan-2-ol)-2-amino-prop-1-yl-4-hydroxybenzene and its analogues for the treatment of chronic pain
EP2353594A1 (en) Compositions comprising tramadol and the co-crystal of celecoxib and L-proline in the treatment of pain
WO2014164784A1 (en) Hdac inhibitor polymorphic forms and methods of use
HK1140683A (en) 1-[2-(2-4-dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of pain or residual symptoms in depression relating to sleep and cognition

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221228

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20221228

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20230627

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20231228

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240105

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240405

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240612

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240911

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240912

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20241122

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20241223

R150 Certificate of patent or registration of utility model

Ref document number: 7611148

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150